Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23

Biochemical Pharmacology

Volumn 69, Issue 9, 2005, Pages 1363-1371

  Ma, Yuzhong ^a   Sachdeva, Karuna ^a   Liu, Jirong ^a   Song, Xiulong ^a   Li, Yuxin ^a   Yang, Dongfang ^a   Deng, Ruitang ^a   Chichester, Clinton O ^a   Yan, Bingfang ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Clofibrate; CYP3A23; Induction; Perfluorodecanoic acid; Pregnenolone 16 Carbonitrile; PXR

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CLOFIBRATE; CYANIDE; CYTOCHROME P450 3A23; CYTOCHROME P450 ISOENZYME; DACTINOMYCIN; PERFLUORODECANOIC ACID; PEROXISOME PROLIFERATOR; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME INDUCTION; LIVER CELL; MALE; MESSENGER RNA SYNTHESIS; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

EID: 17044390675     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.02.011     Document Type: Article

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