CpG oligodeoxynucleotides as a future vaccine for allergic diseases

Allergology International

Volumn 54, Issue 1, 2005, Pages 17-23

  Sano, Kunio ^a   Shirota, Hidekazu ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigen specific; Bronchial asthma; Dendritic cell; Th1 Th2 cell

Indexed keywords

CORTICOSTEROID; DNA VACCINE; OLIGODEOXYNUCLEOTIDE;

ALLERGIC DISEASE; ASTHMA; CPG ISLAND; DENDRITIC CELL; DNA SEQUENCE; DRUG MECHANISM; IMMUNOMODULATION; IMMUNOREGULATION; IMMUNOTHERAPY; INFECTION; INFLAMMATION; INNATE IMMUNITY; PRIORITY JOURNAL; REVIEW; TH1 CELL;

EID: 17044386241     PISSN: 13238930     EISSN: None     Source Type: Journal    
DOI: 10.2332/allergolint.54.17     Document Type: Review

References (59)

1. Tada T. Help, Suppression, and Specific factors. In: Paul WE (ed.). Fundamental Immunology. New York:Raven Press, 1984.
2. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995;155:1151-1164.
3. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-742.
4. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 1999;190:995-1004.
5. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000;101:455-458.
6. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994;265:1237-1240.
7. + T cells. J. Exp. Med. 1998;188:1849-1857.
8. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986;136:2348-2357.
9. Mosmann TR, Coffman RL. Two types of mouse helper T-cell clone: Implications for immune regulation. Immunol. Today 1987;8:223-227.
10. Mosmann TR, Schumacher JH, Street NF et al. Diversity of cytokine synthesis and function of mouse CD4+ T cells. Immunol. Rev. 1991;123:209-229.
11. Tokunaga T, Yamamoto H, Shimada S et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 1984;72:955-962.
12. Yamamoto S, Kuramoto E, Shimada S, Tokunaga T. In vitro augmentation of natural killer cell activity and production of interferon-α/β and -γ with deoxyribonucleic acid fraction from Mycobacterium bovis BCG. Jpn. J. Cancer Res. 1988;79:866-873.
13. Yamamoto S, Yamamoto T, Shimada S et al. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 1992;36:983-997.
14. Yamamoto S, Yamamoto T, Kataoka T, Kuramoto E, Yano O, Tokunaga T. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol 1992;148:4072-4076.
15. Janeway CA Jr. How the immune system works to protect the host from infection: a personal view. Proc. Natl. Acad. Sci. USA 2001;98:7461-7468.
16. Hemmi H, Takeuchi O, Kawai T et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-745.
17. Bauer S, Kirschning CJ, Hacker H et al. Human TLR 9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 2001;98:9237-9242.
18. Takeshita FC, Leifer A, Gursel I et al. Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 2001;167:3555-3558.
19. Krieg AM, Yi AK, Matson S et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995;374:546-549.
20. Roman M, Martin-Orozco E, Goodman JS et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 1997;3:849-854.
21. Broide D, Schwarze J, Tighe H et al. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J. Immunol. 1998;161:7054-7062.
22. Kline JN, Waldschmidt TJ, Businga TR et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J. Immunol. 1998;160:2555-2559.
23. Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete IL-6, IL-12, and IFN-γ. Proc. Natl. Acad. Sci. USA 1996;93:2879-2883.
24. Ballas ZK, Rasmussen WL, Krieg AM. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 1996;157:1840-1845.
25. Sparwasser T, Koch ES, Vabulas RM et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 1998;28:2045-2054.
26. Jakob T, Walker PS, Krieg AM, Udey MC, Vogel JC. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. 1998;161:3042-3049.
27. Jain W, Kitagaki K, Businga T et al. CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma. J. Allergy Clin. Immunol. 2002;110:867-872.
28. Cowdery JS, Chace JH, Yi AK, Krieg AM. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 1996;156:4570-4575.
29. Sparwasser T, Miethke T, Lipford G et al. Bacterial DNA causes septic shock. Nature 1997;386:336-337.
30. Sparwasser T, Miethke T, Lipford G. Macrophages sense pathogens via DNA motifs: induction of TNF-α-mediated shock. Eur. J. Immunol. 1997;27:1671-1679.
31. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 1995;16:34-38.
32. Krieg AM. CpG DNA: a pathogenic factor in systemic lupus erythematosus? J. Clin. Immunol. 1995;15:284-292.
33. Gilkeson GS, Ruiz P, Pippen AM, Alexander AL, Lefkowith JB, Pisetsky DS. Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA. J. Exp. Med. 1996;183:1389-1397.
34. Shao H, Lei S, Sun SL, Xiang J, Kaplan HJ, Sun D. CpG-containing oligodeoxynucleotide 1826 converts the weak uveitogenic rat interphotoreceptor retinoid-binding protein peptide 1181-1191 into a strong uveitogen. J. Immunol. 2003;171:4780-4785.
35. Viglianti GA, Lau CM, Hanley TM, Miko BA, Shlomchik MJ, Marshak-Rothstein A. Activation of autoreactive B cells by CpG dsDNA. Immunity 2003;19:837-847.
36. Ikeda RK, Nayar J, Cho JY et al. Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids. Am. J. Respir. Cell Mol. Biol. 2003;28:655-663.
37. Sur S, Wild JS, Choudhury BK, Sur N, Alam R, Klinman DM. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J. Immunol. 1999;162:6284-6293.
38. Shirota H, Sano K, Kikuchi T, Tamura G, Shirato K. Regulation of T-helper cell type 2 and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs. Am. J. Respir. Cell Mol. Biol. 2000;22:176-182.
39. Kline JN, Kitagaki K, Businga TR, Jain W. Treatment of established asthma in a murine model using CpG oligodeoxynucleotides. Am. J. Physiol. Lung Cell Mol. Physiol. 2002;283:L170-179.
40. Jain W, Businga TR, Kitagaki K, George CL, O'Shaughnessy PT, Kline JN. Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure. Am. J. Physiol. Lung Cell Mol. Physiol. 2003;285:L1137-1146.
41. Shirota H, Sano K, Kikuchi T, Tamura G, Shirato K. Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator. J. Immunol. 2000;164:5575-5582.
42. Santeliz JV, Van Nest G, Traquina P, Larsen E, Wills-Karp M. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J. Allergy Clin. Immunol. 2002;109:455-462.
43. Marshall JD, Abtahi S, Eiden JJ et al. Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes Th1 cytokine expression while downregulating Th2 cytokine expression in PBMCs from human patients with ragweed allergy. J. Allergy Clin. Immunol. 2001;108:191-197.
44. Tighe H, Takabayashi K, Schwartz D et al. Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity. J. Allergy Clin. Immunol. 2000;106:124-134.
45. Horner AA, Takabayashi K, Beck L et al. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity. J. Allergy Clin. Immunol. 2002;10:413-420.
46. Liu N, Ohnishi N, Ni L, Akira S, Bacon KB. CpG directly induces T-bet expression and inhibits IgG 1 and IgE switching in B cells. Nat. Immunol. 2003;4:687-693.
47. Horner AA, Raz E. Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases. J. Allergy Clin. Immunol. 2002;110:706-712.
48. Broide DH, Stachnick G, Castaneda D et al. Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma. J. Clin. Immunol. 2001;21:175-182.
49. Cho HJ, Takabayashi K, Cheng PM et al. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism. Nat. Biotechnol. 2000;18:509-514.
50. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-252.
51. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 1995;182:389-400.
52. Shirota H, Sano K, Hirasawa N et al. Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells. J. Immunol. 2001;167:66-74.
53. Yi AK, Tuetken R, Redford T, Waldschmidt M, Kirsch J, Krieg AM. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 1998;160:4755-4761.
54. Gursel I, Gursel M, Yamada H, Ishii KJ, Takeshita F, Klinman DM. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J. Immunol. 2003;171:1393-1400.
55. Sano K, Shirota H, Terui T, Hattori T, Tamura G. Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner. J. Immunol. 2003;170:2367-2373.
56. Ahmad-Nejad P, Hacker H, Rutz M, Bauer S, Vabulas RM, Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 2002;32:1958-1968.
57. Liang H, Reich CF, Pisetsky DS, Lipsky PE. The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides. J. Immunol. 2000;165:1438-1445.
58. Creticos PS, Eiden JJ, Broide D et al. Immunotherapy with immunostimulatory oligonucleotides linked to purified ragweed Amb a 1 allergen: Effects on antibody production, nasal allergen provocation, and ragweed seasonal rhinitis. J. Allergy Clin. Immunol. 2002;109:742.
59. Tulic MK, Fiset PO, Christodoulopoulos P et al. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J. Allergy Clin. Immunol. 2004;113:235-241.