Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A1 receptors: Evidence from gene-knockout mice

Circulation

Volumn 102, Issue 8, 2000, Pages 902-907

  Zhao, Tingcun ^a   Xi, Lei ^a   Chelliah, Jeya ^a   Levasseur, Joseph E ^a   Kukreja, Rakesh C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine; Ischemia; Myocardial infarction; Nitric oxide synthase; Receptors; Reperfusion

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; NITRIC OXIDE SYNTHASE; THIOUREA DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 0034702909     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.8.902     Document Type: Article

References (36)

1. Characterisation of the infarct-limiting effect of delayed preconditioning: Timecourse and dose-dependency studies in rabbit myocardium
2. The natural history of preconditioning: Cardioprotection depends on duration of transient ischemia and time to subsequent ischemia
3. 1 adenosine receptors in rabbit heart
4. Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning
5. The cardiac effects of adenosine
6. + channels in rabbit heart
7. + channel of vascular smooth muscle cells
8. Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: Evidence from pharmacological inhibition and gene knockout mice
9. Myocardial ischemia/reperfusion injury in the inducible nitric oxide synthase knockout mice
10. Involvement of PKC in the delayed cytoprotection following sublethal ischemia in rabbit myocardium
11. 1 receptor activation
12. Beneficial effects and improved survival in rodent models of septic shock with S-methylthiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase
13. 1 adenosine receptor overexpression increases myocardial resistance to ischemia
14. 1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischaemic preconditioning in rabbit heart
15. Phospholipase D plays a role in ischemic preconditioning in rabbit heart
16. Ischemic preconditioning triggers phospholipase D signaling in rat heart
17. Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved
18. Diversity in function and regulation of MAP kinase pathways
19. Role of p38 MAP kinase in myocardial stress
20. Selective modulation of inducible nitric oxide synthase isozyme in myocardial infarction
21. Contractile depression and expression of proinflammatory cytokines and iNOS in viral myocarditis
22. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
23. Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury
24. Sustained inhibition of nitric oxide by N(G)-nitro-L-arginine improves myocardial function following ischemia/reperfusion in isolated rat heart
25. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
26. Inducible nitric-oxide synthase generates superoxide from the reductase domain
27. Nitric oxide signaling in ischemic heart
28. Role of ATP sensitive potassium channels in long term adaptation to metabolic stress
29. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs
30. Activation of mitochondrial ATP-dependent potassium channels by nitric oxide
31. Pharmacology of ATP-sensitive potassium channel (K(ATP)) openers in models of myocardial ischemia and reperfusion
32. Specific ATP-sensitive potassium channel antagonist 5-hydroxydecanoate blocks ischemic preconditioning in the rat heart
33. K(ATP) channels in rat heart: Blockade of ischemic and acetylcholine-mediated preconditioning by glibenclamide
34. Second window of ischemic preconditioning is mediated by opening of ATP-sensitive potassium channels in the rabbit heart
35. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
36. Antisense oligonucleotides targeting protein kinase C-α, -β I, or -Δ but not -η inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: Involvement of a nuclear factor κ B-dependent mechanism