Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021

Cellular Signalling

Volumn 8, Issue 8, 1996, Pages 575-581

  Ito, Masaaki ^a   Nishikawa, Masakatsu ^a   Fujioka, Masaki ^a   Miyahara, Masatoshi ^a   Isaka, Naoki ^a   Shiku, Hiroshi ^a   Nakano, Takeshi ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aggregation; cGMP specific phosphodiesterase (PDE5); Cyclic nucleotide phosphodiesterase; E4021; Human platelets; PDE inhibitor

Indexed keywords

1 (3 CHLOROANILINO) 4 PHENYLPHTHALAZINE; 1 [6 CHLORO 4 (3,4 METHYLENEDIOXYBENZYLAMINO) 2 QUINAZOLINYL] 4 PIPERIDINECARBOXYLIC ACID; ANTITHROMBOCYTIC AGENT; CELL ENZYME; CILOSTAMIDE; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIPYRIDAMOLE; ENZYME INHIBITOR; ISOENZYME; PHOSPHODIESTERASE; ROLIPRAM;

ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE AGGREGATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; BLOOD PLATELETS; HUMANS; ISOENZYMES; MOLSIDOMINE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PHTHALAZINES; PIPERIDINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; QUINAZOLINES; SIGNAL TRANSDUCTION; THROMBOXANE A2; TISSUE DISTRIBUTION;

EID: 0030460944     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(96)00112-X     Document Type: Article

References (29)

1. 1. Beavo J. (1990) Molecular Pharmacology of Cell Regulation (Beavo J. and Houslay M. D. Eds.), pp. 3-15. John Wiley & Sons, Chichester.
2. 2. Beavo J. A., Conti M. and Heaslip R. J. (1994) Mol. Pharmacol. 46, 399-405.
3. 3. Nicholson C. D., Charlliss R. A. J. and Shahid M. (1991) Trends Pharmacol Sci. 12, 19-27.
4. 4. Saeki T., Adachi H., Takase Y., Yoshitake S., Souda S. and Saito I. (1995) J. Pharmacol. Exp. Ther. 272, 825-831.
5. 5. Miyahara M., Ito M., Itoh H., Shiraishi T., Isaka N., Konishi T. and Nakano T. (1995) Eur. J. Pharmacol. 284, 25-33.
6. 6. Cohen A. H., Hanson K., Morris K., Fouty B., McMurtry I. F., Clarke W. and Rodman D. M. (1996) J. Clin. Invest. 97, 172-179.
7. 7. Hidaka H. and Asano T. (1976) Biochim. Biophys. Acta. 429, 485-497.
8. 8. Simpson A. W. M., Reeves M. L. and Rink T. J. (1988) Biochem. Pharmacol. 37, 2135-2320.
9. 9. Tani T., Sakurai K., Kimura Y., Ishikawa T. and Hidaka H. (1992) Adv. Sec. Mess. Phosph. 25, 215-227.
10. 10. Hidaka H, and Endo T. (1984) Adv. Cyclic Nucleotide Protein Phosphor. Res. 16, 245-259.
11. 11. Saeki T. and Saito I. (1993) Biochem. Pharmacol. 46, 833-839.
12. 12. Sugioka M., Ito M., Masuoka H., Ichikawa K., Konishi T., Tanaka T. and Nakano T. (1994) Nauyn-Schmied. Arch. Pharmacol. 350, 284-293.
13. 13. Hidaka H. and Asano T. (1976) J. Biol. Chem. 251, 7508-7516.
14. 14. Nishikawa M. and Hidaka H. (1982) J. Clin. Invest. 69, 1348-1355.
15. 15. Kodama K., Adachi H., Mori N., and Saito I. (1994) Eur. J. Pharmacol. 263, 93-99.
16. 16. Schwabe U., Miyake M., Ohga Y. and Daly J. W. (1976) Mol. Pharmacol. 12, 900-910.
17. 17. Hidaka H., Hayashi H., Kohri H., Kimura Y., Hosokawa T., Igawa T. and Saitoh Y. (1979) J. Pharmacol. Exp. Ther. 211, 26-30.
18. 18. Hashimoto K., Taira N., Hirata M. and Kokubun M. (1971) Arzneim. Forsch/Drug Res. 21, 1329-1332.
19. 19. Hagiwara M., Endo T., Kanayama T. and Hidaka H. (1984) J. Pharmacol. Exp. Ther. 228, 467-471.
20. 20. Weishaar R. E., Kobylarz-Singer D. C., Stoffen R. P. and Kaplan H. R. (1987) Circ. Res. 61, 539-547.
21. 21. Reeves M. L., Leigh B. K. and England P. J. (1987) Biochem. J. 241, 535-541.
22. 22. Opper C., Schrumpf E., Gear A. R. L. and Wesemann W. (1995) Trhomb. Res. 80, 461-470.
23. 23. Francis S. H., Thomas M. K. and Corbin J. D. (1990) Molecular Pharmacology of Cell Regulation (Beavo J. and Houslay M. D. Eds.), pp. 117-140. John Wiley & Sons, Chichester.
24. 24. Coquil J. F., Brunelle G. and Guédon J. (1985) Biochem. Biophys. Res. Commun. 127, 226-231.
25. 25. Halbrügge M., Friedrich C., Eigenthaler M., Schanzenbächer P. and Walter U. (1990) J. Biol. Chem. 265, 3088-3093.
26. 26. Nishikawa M., Kanamori M. and Hidaka H. (1982) J. Pharmacol. Exp. Ther. 220, 183-190.
27. 27. Groves P. H., Lewis M. J., Cheadle H. A. and Penny W. J. (1993) Circulation 87, 590-597.
28. 28. Radomski M. W., Palmer R. M. J. and Moncada S. (1987) Biochem. Biophys. Res. Commun. 148, 1482-1489.
29. 29. Kimura M., Tani T., Kanbe T. and Wantanabe K. (1985) Arzneim.-Forsch/Drug Res. 35 (II), 1144-1149.