Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency

Cancer Research

Volumn 61, Issue 6, 2001, Pages 2487-2491

  Hollander, M Christine ^a   Kovalsky, Oleg ^a   Salvador, Jesus M ^a   Kim, Kate E ^a   Patterson, Andrew D ^a   Haines, Diana C ^b   Fornace, Albert J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE; PROTEIN; PROTEIN GADD45A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; DNA ADDUCT; DNA REPAIR; EXCISION REPAIR; FEMALE; GENE MUTATION; GENETIC STABILITY; GENOTYPE; INTESTINE TUMOR; LIVER CELL CARCINOMA; LYMPHOBLAST; LYMPHOMA; MALE; MOUSE; NONHUMAN; OVARY TUMOR; PRIORITY JOURNAL; VASCULAR TUMOR;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; DNA REPAIR; FEMALE; GENE DELETION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MUTATION; NEOPLASMS, EXPERIMENTAL; OVARIAN NEOPLASMS; PROTEINS; VASCULAR NEOPLASMS;

EID: 0035866787     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
2. p53-mediated DNA repair responses to UV radiation: Studies of mouse cells lacking p53, p21, and/or gadd45 genes
3. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin
4. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45
5. Genomic instability in Gadd45a-deficient mice
6. Nucleotide excision repair and human syndromes
7. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
8. Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition
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10. Base sequence specificity of a monoclonal antibody binding to (6-4) photoproducts
11. Simultaneous establishment of monoclonal antibodies specific for either cyclobutane pyrimidine dimer or (6-4) photoproduct from the same mouse immunized with ultraviolet-irradiated DNA
12. Estimation of relative mRNA content by filter hybridization to a polythymidylate probe
13. Estimation of relative mRNA content by filter hybridization to a polyuridylic probe
14. Mammalian DNA mismatch repair
15. Blockage of RNA polymerase as a possible trigger for U.V. Light-induced apoptosis
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17. XPC and human homologs of RAD23: Intracellular localization and relationship to other nucleotide excision repair complexes
18. Translocation of a UV-damaged DNA binding protein into a tight association with chromatin after treatment of mammalian cells with UV light
19. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
20. Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair
21. Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors
22. A polymorphism but no mutations in the GADD45 gene in breast cancers