Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma

Journal of Clinical Investigation

Volumn 100, Issue 3, 1997, Pages 597-603

  Weinberg, David S ^a,b   Ruggeri, Bruce ^c   Barber, Michael T ^b   Biswas, Sanjoy ^b   Miknyocki, Sheila ^c   Waldman, Scott A ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

DNA probe; In situ hybridization; Pancreatic ductal cells; Reverse transcription polymerase chain reaction; Tumor marker

Indexed keywords

CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; DNA; MESSENGER RNA;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA PROBE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030762567     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119570     Document Type: Article

References (51)

1. Boring, C.C., T.S. Squires, T. Tong, and S. Montgomery. 1994. Cancer statistics, 1994. CA-Cancer J. Clin. 44:7-26.
2. Durbec, J.P., G. Chevilotte, and J.M. Bidort. 1983. Diet, alcohol, tobacco and the risk of cancer of the pancreas: a case control study. Br. J. Cancer. 47: 463-467.
3. Gold, E.B., L. Gordis, and M.D. Diener. 1985. Diet and other risk factors for cancer of the pancreas. Cancer. 55:460-467.
4. Zheng, W., J.K. McLaughlin, and G. Gridley. 1993. A cohort study of smoking, alcohol consumption and dietary factors for pancreatic cancer. Cancer Causes Control. 4:477-482.
5. Olsen, G.W., J.S. Mandel, R.W. Gibson, and L.W. Wattenberg. 1989. A case control study of pancreatic cancer and cigarettes, alcohol, coffee and diet. Am. J. Public Health. 79:1016-1019.
6. Lowenfels, A.B., P. Maissoneuve, G. Cavallini, and R.W. Ammann. 1993. Pancreatitis and the risk of pancreatic cancer. N. Engl. J. Med. 328:1433-1437.
7. Gullo, L., R. Pezzilli, and A.M. Morelli-Labate. 1994. Diabetes and the risk of pancreatic cancer. N. Engl. J. Med. 331:81-85.
8. Fontham, E.T., and P. Correa. 1989. Epidemiology of pancreatic cancer. Surg. Clin. North Am. 69:551-567.
9. Herrington, M.K., and T.E. Adrian. 1995. On the role of cholecystokinin in pancreatic cancer. Int. J. Pancreatol. 17:121-138.
10. Povoski, S.P., W. Zhou, D.S. Longnecker, R.T. Jensen, S.A. Mantey, and R.H. Bell. 1994. Stimulation of in vivo pancreatic growth in the rat is mediated specifically by way of cholecystokinin A receptors. Gastroenterology. 107: 1135-1146.
11. Mainz, D.L., O. Black, and P.D. Webster. 1973. Hormonal control of pancreatic growth. J. Clin. Invest. 52:2300-2304.
12. Folsch, U.R., K. Winckler, and K.G. Wormsley. 1978. Influence of repeated administration of cholecystokinin and secretin on the pancreas of the rat. Scand. J. Gastroenterol. 13:663-671.
13. Howatson, A.G., and D.C. Carter. 1985. Pancreatic carcinogenesis enhancement by cholecystokinin in the hamster nitrosamine model. Br. J. Cancer. 51:107-114.
14. Douglas, B.R., R.A. Wouterson, J.B. Jansen, and A.J. DeJong. 1989. Influence of cholecystokinin and bombesin on azaserine induced lesions in the rat pancreas. Gastroenterology. 96:462-469.
15. Smith, J.P., S.T. Framer, and T.E. Solomon. 1991. CCK stimulates the growth of six human pancreatic cancer cell lines in serum free medium. Regul. Pep. 32:341-349.
16. Hudd, C., M.C. LaRegina, and J.E. Devine. 1989. Response to exogenous cholecystokinin of six human gastrointestinal cancers xenografted in nude mice. Am. J. Surg. 157:386-394.
17. Wank, S.A., J.R. Pisegna, and A. deWeerth. 1994. Cholecystokinin receptor family. Molecular cloning, structure, and functional expression in rat, guinea pig and human. Ann. NY Acad. Sci. 713:49-66.
18. Wank, S.A. 1995. Cholecystokinin receptors. Am. J. Physiol. 269:G628-G646.
19. Zhou, W., S. Povoski, and R.H. Bell. 1993. Overexpression of messenger RNA for the cholecystokinin-A receptor and novel expression of messenger RNA for gastrin (cholecystokinin-B) receptor in azaserine induced rat pancreatic carcinoma. Carcinogenesis (Oxf.). 14:2189-2192.
20. Smith, J.P., G. Liu, V. Soundararajan, P.J. McLaughlin, and I.S. Zagon. 1994. Identification and characterization of CCK-B/gastrin receptors in human pancreatic cancer cell lines. Am. J. Physiol. 266:R277-R283.
21. Hall, P.A., and N.R. Lemoine. 1993. Models of pancreatic cancer. Cancer Surv. 16:135-155.
22. Poston, G.J., J. Gillespie, and P.J. Guillou. 1991. Biology of pancreatic cancer. Gut. 32:800-812.
23. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Anal. Biochem. 162:156-157.
24. Puissant, C., and L.M. Houdebine. 1990. An improvement of the single step method of RNA extraction by acid guanidinium thiocyanate phenol chloroform extraction. Biotechniques. 8:148-149.
25. Beverley, S.M. 1994. Enzymatic amplification of RNA by PCR. In Current Protocols in Molecular Biology. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Mith, and K. Struhl, editors. John Wiley & Sons Inc., New York. 15.4.1-15.4.6.
26. Kramer, M., and D.M. Coen. 1994. Enzymatic amplification of DNA by PCR: standard procedures and optimization. In Current Protocols in Molecular Biology. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Mith, and K. Struhl, editors. John Wiley & Sons Inc., New York. 15.1.1-15.1.8.
27. Walther, W., U. Stein, and C. Eder. 1994. RNA analysis using miniprep RNA in reverse transcription PCR. Biotechniques. 17:674-675.
28. Bellacosa, A., D. deFeo, A.K. Godwin, D.W. Bell, I.Q. Cheng, D.A. Altomare, and M. Wan. 1995. Molecular alterations in the AKT-2 oncogene in ovarian and breast carcinomas. Cancer. 64:280-285.
29. Larsson, L.I., T. Christensen, and H. Dalboge. 1988. Detection of propiomelanocortin mRNA by in situ hybridization using a biotinylated oligonucleotide probe and avidin-alkaline phosphatase histochemistry. Histochemistry. 89:109-116.
30. Marchetti, D., I.E. McCutcheon, M.J. Ross, and G.L. Nicholson. 1995. Inverse expression of neurotrophins and neurotrophin receptors at the invasion front of human melanoma brain metastases. Int. J. Oncol. 7:87-94.
31. Wank, S.A., J.R. Pisegna, and A. de Weerth. 1992. Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression. Proc. Natl. Acad. Sci. USA. 89:8691-8695.
32. Monstein, H.J., A.G. Nylander, A. Salehi, D. Chen, I. Lundquist, and R. Hakanson. 1996. Cholecystokinin-A and cholecystokinin-B/gastrin receptor mRNA expression in the gastrointestinal tract and pancreas of the rat and man. Scand. J. Gastroenterol. 31:383-390.
33. Trapnell, B.C., C.S. Chu, P.K. Paako, T.C. Banks, K. Yoshimura, V.J. Ferrans, M.S. Cherncik, and R.G. Crystal. 1991. Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proc. Natl. Acad. Sci. USA. 88: 6565-6569.
34. Crawford, I., P.C. Maloney, P.L. Zeitlin, W.B. Guggino, S.C. Hyde, H. Turley, K.C. Gatter, A. Harris, and C.F. Higgins. 1991. Immunocytochemical localization of the cystic fibrosis gene product CFTR. Proc. Natl. Acad. Sci. USA. 88:9262-9266.
35. de Weerth, A., J. Pisegna, K. Huppi, and S.A. Wank. 1993. Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. Biochem. Biophys. Res. Commun. 194:811-818.
36. Doss, D.N., N.A. Mekhail, and E.Y. Ekladdios. 1991. The localization of cholecystokinin immunoreactivity in the rat ovary and uterine tube. Neuropeptides. 18:87-91.
37. Sacerdote, P., C.J. Wiedermann, L.M. Wahl, C.B. Pert, and M.R. Ruff. 1991. Visualization of cholecystokinin receptors on a subset of human monocytes and in rat spleen. Peptides (Tarryt.). 12:167-176.
38. Brennan, M.F., T.J. Kinsella, and E.S. Casper. 1993. Cancer of the pancreas. In Cancer-Principles and Practice of Oncology, vol. 1. V.T. Devita, S. Hellman, and S.A. Rosenberg, editors. J.B. Lipincott Company, Philadelphia. 849.
39. Watanabe, H., N. Sawabu, Y. Songur, Y. Yamaguchi, O. Satomura, H. Ohta, Y. Motoo, T. Okai, and T. Wakabayashi. 1996. Detection of k-ras point mutations at codon 12 in pure pancreatic juice for the diagnosis of pancreatic cancer by PCR-RFLP analysis. Pancreas. 12:18-24.
40. van Es, J.M., M.M. Polak, F.M. van den Berg, T.B. Ramsoekh, M.E. Craanen, R.H. Hruban, and G.J. Offerhaus. 1995. Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of k-ras and overexpression of the p53 protein product. J. Clin. Pathol. (Lond.). 48:218-222.
41. Susini, C., A. Estival, and J.L. Scemama. 1986. Studies on human pancreatic acini: actions of secretagogues on amylase release and cellular cyclic AMP accumulation. Pancreas. 1:124-129.
42. Povoski, S.P., W. Zhou, D.S. Longnecker, and R. Bell. 1994. Cholecystokinin receptor characterization and cholecystokinin-A receptor mRNA expression in transgenic mouse pancreatic carcinomas and dysplastic pancreas. Oncol. Res. 6:411-417.
43. Logsdon, C.D. 1995. Pancreatic cut cell cultures: there is more to ducts than salty water. Gastroenterology. 109:1005-1009.
44. Iovanna, J.L., P.L. de la Porte, and J.-C. Dagorn. 1992. Expression of genes associated with dedifferentiation and cell proliferation during pancreatic regeneration following acute pancreatitis. Pancreas. 7:712-718.
45. Hall, P.A., and N.R. Lemoine. 1992. Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas. J. Pathol. 166:97-103.
46. Hoosein, N.M., P.A. Keiner, R.C. Curry, and M.G. Bratttain. 1990. Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide. Exp. Cell Res. 186:15-21.
47. Matsumori, Y., N. Katakami, M. Ito, T. Taniguchi, N. Iwata, and T. Takaishi. 1995. Cholecystokinin-B/gastrin receptor: a novel molecular probe for human small cell lung cancer. Cancer Res. 55:276-279.
48. Rehfeld, J.F., and W.W. van Solinge. 1994. The tumor biology of gastrin and cholecystokinin. Adv. Cancer Res. 63:295-347.
49. Le Meuth, V., V. Philouze-Rome, I. Le Huerou-Luron, M. Formal, N. Vaysse, C. Gespach, P. Guilloteau, and D. Fourmy. 1993. Differential expression of the A-and B-subtypes of the cholecystokinin/gastrin receptors in the developing calf pancreas. Endocrinology. 133:1182-1191.
50. Escribano, M.J., J. Cordier, M. Nap, F. Ten Kate, and P. Burtin. 1986. Differentiation antigens in fetal human pancreas. Re-expression in cancer. Int. J. Cancer. 38:155-160.
51. Trede, M., G. Schwall, and H.D. Saeger. 1990. Survival after pancreaticoduodenectomy. Ann. Surg. 21:447-458.