Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen

Gastroenterology

Volumn 119, Issue 1, 2000, Pages 162-171

  Singh, Pomila ^a   Velasco, Marco ^b   Given, Randall ^b   Varro, Andrea ^c   Wang, Timothy C ^d  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Vel Lab Research   (United States)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; CARCINOGEN; PROGASTRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; CHEMICAL CARCINOGENESIS; COLON ADENOMA; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; HORMONE RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0034235903     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2000.8527     Document Type: Article

References (49)

1. Cancer Facts and Figures-1999. Atlanta, GA: American Cancer Society, 1999:1-36.
2. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170.
3. Kennedy EP, Hamilton SR. Genetics of colorectal cancer. Semin Surg Oncol 1998;15:126-130.
4. Brattain MG, Howell G, Sun LZ, Willson JK. Growth factor balance and tumor progression. Curr Opin Oncol 1994;6:77-81.
5. Reddy BS. Nutritional factors and colon cancer. Crit Rev Food Sci Nutr 1995;35:175-190.
6. Singh P, Dai D, Wu H, Owlia A. Role of autocrine and endocrine gastrin-like peptides in colon cancers. Curr Opin Gastroenterol 2000;16:68-77.
7. Lipkin M. Biomarkers of increased susceptibility to gastrointestinal cancer: New application to studies of cancer prevention in human subjects. Cancer Res 1988;48:235-245.
8. Walsh JH. Gastrin. In: JH Walsh, GJ Dockray, eds. Gut Peptides. New York: Raven, 1994:75-121.
9. Johnson LR. New aspects of the trophic action of gastrointestinal hormones. Gastroenterology 1977;72:788-792.
10. Wang TC, Dockray GJ. Lessons from genetically engineered animal models. I. Physiological studies with gastrin in transgenic mice. Am J Physiol 1999;277:G6-G11.
11. Singh P, Townsend CM Jr, Thompson JC, Narayan S, Guo YS. Hormones in colon cancer; past and prospective studies. Cancer J 1990;3:28-33.
12. Singh P, Walker JP, Townsend CM Jr, Thompson JC. Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26), in Balb/c mice. Cancer Res 1986;46:1612-1616.
13. Singh P, Le S, Beauchamp RD, Townsend CM Jr, Thompson JC. Inhibition of pentagastrin-stimulated up-regulations of gastrin receptors and growth of mouse colon tumor (MC-26), in vivo by proglumide, a gastrin receptor antagonist. Cancer Res 1987;47:5000-5004.
14. Sirinek KR, Levine BA, Moyer M. Pentagastrin stimulates in vitro growth of normal and malignant human colon epithelial cells. Am J Surg 1985;149:35-39.
15. Guo YS, Baijal M, Jin GF, Townsend CM Jr, Singh P. Growth-promoting effects of gastrin in vitro: Absence of autocrine effects. In Vitro Cell Dev Biol 1990;26:871-877.
16. Dai B, Xu Z, Dhruva B, Espejo R, Singh P. Gastrin gene expression in human colon cancer cells: Autocrine role of gastrin (abstr). Gastroenterology 1992;102:A352.
17. Baldwin GS, Zhang QX. Measurement of gastrin and transforming growth factor α messenger RNA levels in colonic carcinoma cell lines by quantitative polymerase chain reaction. Cancer Res 1992;52:2261-2267.
18. Finley GG, Koski RA, Melhem MF, Pipas JM, Meisler AL Expression of gastrin gene in the normal human colon and colorectal adenocarcinoma. Cancer Res 1993;53:2919-2926.
19. Van Solinge WW, Nielsen FC, Friis-Hansen L, Falkmer UG, Rehfeld JF. Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterology 1993;104:1099-1107.
20. Xu Z, Dai B, Dhruva B, Singh P. Gastrin gene expression in human colon cancer cells measured by a simple competitive PCR method. Life Sci 1994;54:671-678.
21. Singh P, Owlia A, Varro A, Dai B, Rajaraman S, Wood T. Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. Cancer Res 1996;56:4111-4115.
22. Hollande F, Imdahl A, Mantamadiotis T, Ciccotosto G, Shulkes D, Baldwin GS. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line. Gastroenterology 1997;113:1576-1588.
23. Kochman ML, DelValle J, Dickinson CJ, Boland CR. Post-translation processing of gastrin in neoplastic human colonic tissues. Biochem Biophys Res Commun 1992;189:1165-1169.
24. Singh P, Xu Z, Dai B, Rajaraman S, Dhruva B. Incomplete processing of progastrin expressed by colon cancer cells: Role of non-carboxyamidated gastrin in proliferation. Am J Physiol 1994;266:G459-G468.
25. Seva C, Dickinson C, Yamada T. Growth-promoting effects of glycine-extended progastrin. Science 1994;265:410-412.
26. Ciccotosto GD, McLeish A, Hardy KJ, Shulkes A. Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology 1995;109:1142-1153.
27. Singh P, Owlia A, Espeijo R, Dai B. Novel gastrin receptors mediate mitogenic effects of gastrin processing intermediates of gastrin on Swiss 3T3 fibroblasts. J Biol Chem 1995;270:8429-8438.
28. Wang TC, Koh TJ, Varro A, Cahill R, Dangler CA, Fox JA, Dockray GJ. Processing and proliferative effects of human progastrin in transgenic mice. J Clin Invest 1996;98:1918-1929.
29. Koh T, Dockray G, Varro A, Cahill R, Dangler C, Fox J, Wang T. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J Clin Invest 1999;103:1119-1126.
30. Koh TJ, Goldenring JR, Ito S, Mashimo H, Kopin AS, Varro A, Dockray GJ, Wang TC. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology 1997;113:1015-1025.
31. Williamson RCN, Bauer FLR, Oscarson JEA, Ross JS, Malt RA. Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel. Cancer Res 1978;38:3812-3823.
32. Oscarson JEA, Veen HF, Ross JS, Malt RA. Ileal resection potentiates 1,2,-dimethylhydrazine-induced colonic carcinogenesis. Ann Surg 1979;189:503-508.
33. Karlin DA, McBath M, Jones RD, Elwyn KD, Romsdahl MM. Hypergastrinemia and colorectal carcinogenesis in the rat. Cancer Lett 1985;29:73-78.
34. Pinson DM, Havu N, Sztern MI, Mattsson H, Looney GA, Kimler BF, Hurwitz A. Drug-induced hypergastrinemia: Absence of trophic effects on colonic carcinoma in rats. Gastroenterology 1995;108:1068-1074.
35. McLellan EA, Bird RP. Specificity study to evaluate induction of aberrant crypts in murine colons. Cancer Res 1988;48:6182-6186.
36. McLellan A, Bird RP. Aberrant crypts: Potential preneoplastic lesions in the murine colon. Cancer Res 1988;48:6187-6192.
37. Pretlow TP, Barrow BJ, Ashton WS, O'Riodan MA, Pretlow TG, Jurcisek JA, Stellato TA. Aberrant crypts: Putative preneoplastic foci in human colon mucosa. Cancer Res 1991;51:1564-1567.
38. Roncucci L, Stamp D, Medline A, Cullen JB, Bruce WR. Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum Pathol 1991;22:287-294.
39. Singh P, Velasco M, Given R, Wargovich M, Varro A, Wang TC. Mice over-expressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM. Am J Physiol 2000;278:G390-G399.
40. Wargovich MJ, Chen CD, Harris C, Yang E, Velasco M. Inhibition of aberrant crypt growth by non-steroidal anti-inflammatory agents and differentiation agents in the rat colon. Int J Cancer 1995;60:515-519.
41. Nemeth J, Taylor B, Pauwels S, Varro A, Dockray GJ. Identification of progastrin derived peptides in colorectal carcinoma extracts. Gut 1993;34:90-95.
42. Sobhani I, Lehy T, Laurent-Puig P, Cadiot G, Ruszniewski P, Mignon M. Chronic endogenous hypergastrinemia in humans: Evidence for a mitogenic effect on the colonic mucosa. Gastroenterology 1993;105:22-30.
43. Orbuch M, Venzon DJ, Lubensky IA, Weber HC, Gibril F, Jensen RT. Prolonged hypergastrinemia does not increase the frequency of colonic neoplasia in patients with Zollinger-Ellison syndrome. Dig Dis Sci 1996;41:604-613.
44. Penman ID, EL-Omar E, Ardill JES, McGregor JR, Galloway DJ, O'Dwyer PJ. Plasma gastrin concentrations are normal in patients with colorectal neoplasia and unaltered following tumor resection. Gastroenterology 1994;100:1264-1270.
45. Breuer-Katschinski B, Nemes K, Marr A, Leiendecker B, Breuer N, Goebell H, the Colorectal Adenoma Study Group. Helicobacter pylori and the risk of colonic adenomas. Digestion 1999;60:210-215.
46. Lamberts R, Wartenberg T, Creutzfeldt W. Role of circulating gastrin in colorectal adenomas and carcinomas. Digestion 1999;60:101-109.
47. Thorburn CM, Friedman GD, Dickinson CJ, Vogelman JH, Orentreich N, Parsonnet J. Gastrin and colorectal cancer: A prospective study. Gastroenterology 1998;115:275-280.
48. D'Agostino L, Pignata S, Tritto G, D'Adamo G, Contegiacomo A, Daniele BR, Calderopoli R, Pizzi C, Squame G, Mazzacca G. Hypergastrinemia in rats with azoxymethylene-induced colon cancers. Int J Cancer 1995;61:223-226.
49. Nakata H, Wang S, Chung DC, Westwick JK, Tillotson LG. Oncogenic ras induces gastrin gene expression in colon cancer. Gastroenterology 1998;115:1144-1153.