Immunoinflammatory responses and fibrogenesis

Medical Electron Microscopy

Volumn 37, Issue 3, 2004, Pages 141-148

  Azouz, Abdallah ^a   Razzaque, Mohammed S ^b,c   El Hallak, Moussa ^a   Taguchi, Takashi ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b FORSYTH INSTITUTE   (United States)

^c NAGASAKI UNIVERSITY   (Japan)

Author keywords

Cell cell interaction; Cytokines; Extracellular matrix; Fibrogenesis

Indexed keywords

CYTOKINE; GROWTH FACTOR; INTERFERON; MATRIX METALLOPROTEINASE; GROWTH PROMOTOR;

CELL ACTIVATION; CELL DIFFERENTIATION; CELL INTERACTION; CELL PROLIFERATION; CELLULAR IMMUNITY; FIBROGENESIS; FIBROSIS; GENETICS; GRANULOMA; IMMUNE RESPONSE; INFECTION; INFLAMMATION; INFLAMMATORY CELL; LYMPHOCYTE PROLIFERATION; MOLECULAR INTERACTION; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; SCAR; T LYMPHOCYTE; TH1 CELL; TH2 CELL; ANIMAL; CELL COMMUNICATION; EXTRACELLULAR MATRIX; HUMAN; IMMUNOLOGY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; WOUND HEALING;

ANIMALS; CELL COMMUNICATION; CYTOKINES; EXTRACELLULAR MATRIX; FIBROSIS; GROWTH SUBSTANCES; HUMANS; INFLAMMATION; TH1 CELLS; TH2 CELLS; WOUND HEALING;

EID: 16644396362     PISSN: 09184287     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00795-004-0255-2     Document Type: Review

References (89)

1. Razzaque MS, Taguchi T (2003) Factors that influence and contribute to the regulation of fibrosis. Contrib Nephrol 139:1-11
2. Razzaque MS, Taguchi T (2003) Pulmonary fibrosis: cellular and molecular events. Pathol Int 53:133-145
3. Razzaque MS, Taguchi T (2002) Cellular and molecular events leading to tubulointerstitial fibrosis. Med Electron Microsc 35:68-80
4. Panayi GS, Lanchbury JS, Kingsley GH (1992) The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 35:729-735
5. Krzesicki RF, Fleming WE, Winterrowd GE, Hatfield CA, Sanders ME, Chin JE (1991) T lymphocyte adhesion to human synovial fibroblasts. Role of cytokines and the interaction between intercellular adhesion molecule 1 and CD11a/CD18. Arthritis Rheum 34:1245-1253
6. Bombara MP, Webb DL, Conrad P, Marlor CW, Sarr T, Ranges GE, Aune TM, Greve JM, Blue ML (1993) Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines. J Leukocyte Biol 54:399-406
7. Burger D, Rezzonico R, Li JM, Modoux C, Pierce RA, Welgus HG, Dayer JM (1998) Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: involvement of membrane-associated cytokines. Arthritis Rheum 41:1748-1759
8. Romagnani S (1999) Th1/Th2cells. Inflamm Bowel Dis 5:285-294
9. Grzych JM, Pearce EJ, Cheever A, Caulada ZA, Caspar P, Hieny S, Lewis FA, Sher A (1991) Egg deposition is the major stimulus for the production of Th2 cytokines in murine Schistosomiasis mansoni. J Immunol 146:1322-1327
10. Pearce EJ, Caspar P, Gryzch JM, Lewis FA, Sher A (1991) Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a helminth, Schistosoma mansoni. J Exp Med 173:159-166
11. + T cells in acute Schistosoma mansoni infection. Eur J Immunol 28:1408-1416
12. Estaquier J, Marguerite M, Sahuc F, Bessis N, Auriault C, Ameisen JC (1997) Interleukin-10-mediated T cell apoptosis during the T helper type 2 cytokine responses in murine Schistosoma mansoni parasite infection. Eur Cytokine Netw 8:153-160
13. Phillips SM, DiConza JJ, Gold JA, Reid WA (1997) Schistosomiasis in the congenitally athymic (nude) mouse. I. Thymic dependency of eosinophilia, granuloma formation, and host morbidity. J Immunol 118:594-599
14. Iacomini J, Ricklan D, Stadecker M (1995) T cells expressing the gamma delta T cell receptor are not required for egg granuloma formation in schistosomiasis. Eur J Immunol 25:884-888
15. Hernandez HJ, Wang Y, Tzellas N, Stadecker MJ (1997) Expression of class II, but not class I, major histocompatibility complex molecules is required for granuloma formation in infection with Schistosoma mansoni. Eur J Immunol 27:1170-1176
16. Chikunguwo S, Kanazawa T, Dayal Y, Stadecker M (1991) The cell-mediated response to schistosomal antigens at the clonal level. In vivo functions of cloned murine egg antigen-specific CD4+ T helper type 1 lymphocytes. J Immunol 147:3921-3925
17. Stadecker MJ, Hernandez HJ (1998) The immune response and immunopathology in infection with Schistosoma mansoni: a key role of major egg antigen Sm-p40. Parasite Immunol 20:217-221
18. Hernandez HJ, Edson CM, Harn DA, Ianelli CJ, Stadecker MJ (1998) Schistosoma mansoni: genetic restriction and cytokine profile of the CD4+ T helper cell response to dominant epitope peptide of major egg antigen Sm-p40. Exp Parasitol 90:122-130
19. + Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage. J Immunol 148:2283-2290
20. Hernandez HJ, Wang Y, Stadecker MJ (1997) In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granuloma formation. J Immunol 158:4832-4837
21. Wynn TA, Eltoum I, Cheever AW, Lewis FA, Gause WC, Sher A (1993) Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J Immunol 151:1430-1440
22. Scott P, Natovitz P, Coffman RL, Pearce E, Sher A (1998) Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med 168:1675-1684
23. Chen ES, Greenlee BM, Wills-Karp M, Moller DR (2001) Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin. Am J Respir Cell Mol Biol 24:545-555
24. Kaufman J, Graf BA, Leung EC, Pollock SJ, Koumas L, Reddy SY, Blieden TM, Smith TJ, Phipps RP (2001) Fibroblasts as sentinel cells: role of the CD40-CD40 ligand system in fibroblast activation and lung inflammation and fibrosis. Chest 120:S53-S55
25. Van Kooten C, Banchereau J (2002) CD40-CD40 ligand. J Leukoc Biol 67:1-12
26. Fries KM, Sempowski GD, Gaspari AA, Blieden T, Looney RJ, Phipps RP (1995) CD40 expression by human fibroblasts. Clin Immunol Immunopathol 77:42-51
27. Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, Muller-Berghaus G, Kroczek RA (1998) CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature (Lond) 391:591-594
28. Yellin MJ, Winikoff S, Fortune SM, Baum D, Crow MK, Lederman S, Chess L (1995) Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation. J Leukoc Biol 58:209-216
29. Sempowski GD, Chess PR, Phipps RP (1997) CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. J Immunol 158:4670-4677
30. Sempowski GD, Chess PR, Moretti AJ, Padilla J, Phipps RP, Blieden TM (1997) CD40 mediated activation of gingival and periodontal ligament fibroblasts. J Periodontol 68:284-292
31. Cao HJ, Wang HS, Zhang Y, Lin HY, Phipps RP, Smith TJ (1998) Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression. Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy. J Biol Chem 273:29615-29625
32. Kroczek RA, Graf D, Brugnoni D, Giliani S, Korthuer U, Ugazio A, Senger G, Mages HW, Villa A, Notarangelo LD (1994) Defective expression of CD40 ligand on T cells causes "X-linked immunodeficiency with hyper-IgM (HIGM1)." Immunol Rev 138:39-59
33. Boumpas DT, Furie R, Manzi S, Illei GG, Wallace DJ, Balow JE, Vaishnaw A, BG9588 Lupus Nephritis Trial Group (2003) A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 48:719-727
34. Adawi A, Zhang Y, Baggs R, Finkelstein J, Phipps RP (1998) Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome. Am J Pathol 152:651-657
35. Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, Phipps RP (1998) Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. Clin Immunol Immunopathol 89:222-230
36. Chambers CA, Allison JP (1997) Co-stimulation in T cell responses. Curr Opin Immunol 9:396-404
37. Shahinian A, Pfeffer K, Lee KP, Kundig TM, Kishihara K, Wakeham A, Kawai K, Ohashi PS, Thompson CB, Mak TW (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609-612
38. Gross JA, Callas E, Allison JP (1992) Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol 149:380-388
39. Okazaki T, Nakao A, Nakano H, Takahashi F, Takahashi K, Shimozato O, Takeda K, Yagita H, Okumura K (2001) Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice. J Immunol 167:1977-1981
40. Piguet PF, Collart MA, Grau GE, Kapanci Y, Vassalli P (1989) Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy. J Exp Med 170:655-663
41. Piguet PF, Vesin C (1994) Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur Respir J 7:515-518
42. Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, Gauldie J (1998) Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta 1 and myofibroblasts. Am J Pathol 153:825-832
43. Ulich TR, Shin SS, del Castillo J (1993) Haematologic effects of TNF. Res Immunol 144:347-354
44. Nelson S, Bagby GJ, Bainton BG, Wilson LA, Thompson JJ, Summer WR (1998) Compartmentalization of intraalveolar and systemic LPS-induced TNF and the pulmonary inflammatory response. J Infect Dis 159:189-194
45. Phan SH, Kunkel SL (1992) Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res 18:29-43
46. Dinarello CA (1998) Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann NY Acad Sci 856:1-11
47. Murphy JE, Robert C, Kupper TS (2000) Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity. J Invest Dermatol 114:602-608
48. Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J (2001) Transient expression of IL-1 beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 107:1529-1536
49. Piguet P, Vesin C, Grau G, Thompson RC (1993) Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica. Cytokine 5:57-61
50. Rolfe MW, Standiford TJ, Kunkel SL, Burdick MD, Gilbert AR, Moore SA, Lynch JP, Stricter RM (1993) Interleukin-1 receptor antagonist expression in sarcoidosis. Am Rev Respir Dis 148:1378-1384
51. Smith DR, Kunkel SL, Standiford TJ, Rolfe MW, Lynch JP III, Arenberg DA, Wilke CA, Burdick MD, Martinez FJ, Hampton JN, Whyte RI, Orringer MB, Stricter RM (1995) Increased interleukin-1 receptor antagonist in idiopathic pulmonary fibrosis. A compartmental analysis. Am J Respir Crit Care Med 151:1965-1973
52. Stern AS, Podlaski FJ, Huhnes JD, Pan YC, Quinn PM, Wolitzky AG, Familletti PC, Stremlo DL, Truitt T, Chizzonite R (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 87:6808-6812
53. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170:827-845
54. Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U (1996) A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc Natl Acad Sci USA 93:14002-14007
55. lpr mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J Immunol 170:3915-3925
56. Wynn TA, Cheever AW, Jankovic D, Poindexter RW, Caspar P, Lewis FA, Sher A (1995) IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature (Lond) 376: 594-596
57. Duncan MR, Berman B (1989) Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin-1-alpha and beta and tumor necrosis factor-alpha and beta. J Invest Dermatol 92:699-706
58. Giri SN, Hyde DM, Marafino BJ (1986) Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice. Biochem Med Metab Biol 36:194-197
59. Brody AR, Bonner JC, Badgett A (1993) Recombinant interferon-gamma reduces PDGF-induced lung fibroblast growth but stimulates PDGF production by alveolar macrophages in vitro. Chest 103:121S-122S
60. Spoelstra FM, Postma DS, Hovenga H, Noordhoek JA, Kauffman HF (1999) Interferon-gamma and interleukin-4 differentially regulate ICAM-1 and VCAM-1 expression on human lung fibroblasts. Eur Respir J 14:759-766
61. Keane MP, Belperio JA, Burdick MD, Strieter RM (2001) IL-12 attenuates bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 281:L92-L97
62. Hein R, Behr J, Hundgen M, Hunzelmann N, Meurer M, Braun-Falco O, Urbanski A, Krieg T (1992) Treatment of systemic sclerosis with gamma-interferon. Br J Dermatol 126:496-501
63. Ziesche R, Hofbauer E, Wittmann K, Petkov V, Block LH (1999) A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. N Engl J Med 341:1264-1269
64. Jimenez SA, Freundlich B, Rosenbloom J (1984) Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J Clin Invest 74:1112-1116
65. Gurujeyalakshmi G, Giri SN (1995) Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression. Exp Lung Res 2:791-808
66. Giri SN, Hyde DM, Marafino BJ Jr (1986) Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice. Biochem Med Metabol Biol 36:194-197
67. Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N, Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, de Crombrugghe B, Watanabe T, Okazaki I (2003) Interferon alpha down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology 38:890-899
68. Postlethwaite AE, Holness MA, Katai H, Raghow R (1992) Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin-4. J Clin Invest 90:1479-1485
69. Keane MP, Stricter RM (2002) The importance of balanced proinflammatory and anti-inflammatory mechanisms in diffuse lung disease. Respir Res 3:5
70. Rankin JA, Picarella DE, Geba GP, Temann UA, Prasad B, DiCosmo B, Tarallo A, Stripp B, Whitsett J, Flavell RA (1996) Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci USA 93:7821-7825
71. Izbicki G, Breuer R (2003) IL-4 is not a key profibrotic cytokine in bleomycin-induced lung fibrosis model. J Immunol 171:2767-2768
72. Fallon PG, Richardson EJ, McKenzie GJ, McKenzie AN (2000) Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J Immunol 164:2585-2591
73. Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA (1999) An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 104:777-785
74. Oriente A, Fedarko NS, Pacocha SE, Huang SK, Lichtenstein LM, Essayan DM (2000) Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts. J Pharmacol Exp Ther 292:988-994
75. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103:779-788
76. Chiaramonte MG, Mentink-Kane M, Jacobson BA, Cheever AW, Whitters MJ, Goad MEP, Wong A, Collins M, Debra D, Donaldson DD, Grusby MJ, Wynn TA (2003) Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197:687-701
77. Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kuhn R, Muller W, Trinchieri G, Sher A (1996) In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 157:798-805
78. Nelson DR, Lauwers GY, Lau JY, Davis GL (2000) Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology 118:655-660
79. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E, Henson PM, Noble PW (2002) Resolution of lung inflammation by CD44. Science 296:155-158
80. 1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains. Am J Respir Cell Mol Biol 27:141-150
81. Schrier DJ, Phan SH (1984) Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamide-sensitive T cells. Am J Pathol 116:270-278
82. Cook DN, Brass DM, Schwartz DA (2002) A matrix for new ideas in pulmonary fibrosis. Am J Resp Cell Mol Biol 27:122-124
83. Razzaque MS, Foster CS, Ahmed AR (2002) Role of enhanced expression of m-CSF in conjunctiva affected by cicatricial pemphigoid. Invest Ophthalmol Vis Sci 43:2977-2983
84. Razzaque MS, Foster CS, Ahmed AR (2003) Role of collagen-binding heat shock protein 47 and transforming growth factor beta 1 in conjunctival scarring in ocular cicatritial pemphigoid. Invest Ophthalmol Vis Sci 44:1616-1621
85. Razzaque MS, Foster CS, Ahmed AR (2003) Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci 44:1998-2003
86. Razzaque MS, Ahmed B, Foster CS, Ahmed AR (2003) IL-4 induces m-CSF, HSP47 and collagen by conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci 44:3417-3423
87. Razzaque MS, Foster CS, Ahmed AR (2004) Role of macrophage migration inhibitory factor in conjunctival pathology in cicatricial pemphigoid. Invest Ophthalmol Vis Sci 45:1174-1181
88. Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA (2002) Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci USA 99:6292-6297
89. Kaminski N, Zuo F, Cojocaro G, Yakhini Z, Ben-Dor A, Morris D, Sheppard D, Pardo A, Selman M, Heller RA (2002) Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans. Chest 121(suppl 3):31S-32S