The immune response and immunopathology in infection with Schistosoma mansoni: A key role of major egg antigen Sm-p40

Parasite Immunology

Volumn 20, Issue 5, 1998, Pages 217-221

  Stadecker, Miguel J ^a   Hernandez, Hector J ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Egg antigens; Granuloma; Schistosomiasi; T cell epitopes; T cell subsets

Indexed keywords

CD4 ANTIGEN; EPITOPE; PARASITE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; HOST PARASITE INTERACTION; IMMUNOMODULATION; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, HELMINTH; HELMINTH PROTEINS; HUMANS; MICE; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

ANIMALIA; SCHISTOSOMA; SCHISTOSOMA MANSONI;

EID: 0031858012     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1998.00150.x     Document Type: Conference Paper

References (30)

1. Andrade Z.A. & Warren K.S. (1964) Mild prolonged schistosomiasis in mice: alteration in host response with time and the development of portal fibrosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 58, 53
2. Boros D.L. (1986) Immunoregulation of granuloma formation in murine schistosomiasis mansoni. Annals of the New York Academy of Sciences 465, 313
3. Boros D.L., Pelley R.P. & Warren K.S. (1975) Spontaneous modulation of granulomatous hypersensitivity in schistosomiasis mansoni. Journal of Immunology 114, 1437
4. Bosshardt S.C., Freeman Jr G.L., Secor W.E. & Colley D.G. (1997) IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni. Parasite Immunology 19, 347
5. Cai Y., Langley J.G., Smith D.I. & Boros D.L. (1996) A cloned major Schistosoma mansoni egg antigen with homologies to small heat shock proteins elicits Th1 responsiveness. Infection and Immunity 64, 1750
6. Cao, M., Chao H. & Doughty B.L. (1993) Cloning of a cDNA encoding an egg antigen homologue from Schistosoma mansoni. Molecular and Biochemical Parasitology 58, 169
7. Cheever A.W., Duvall R.H., Hallack Jr. T. A., Minker R.G., Malley J.D. & Malley K.G. (1987) Variation of hepatic fibrosis and granuloma size among mouse strains infected with Schistosoma mansoni. American Journal of Tropical Medicine and Hygiene 37, 85
8. Chikunguwo S.M., Kanazawa T., Dayal Y. & Stadecker M.J. (1991) The cell-mediated response to schistosomal antigens at the clonal level. In vivo functions of cloned murine egg antigen-specific CD4+ T helper type 1 lymphocytes. Journal of Immunology 147, 3921
9. Chikunguwo S.M., Quinn J.J., Harn D.A. & Stadecker M.J. (1993) The cell-mediated response to schistosomal antigens at the clonal level. III. Identification of soluble egg antigens recognized by cloned specific granulomagenic murine CD4+ Th-1-type lymphocytes. Journal of Immunology 150, 1413
10. Colley D.G., Montesano M.A., Eloi-Santos S.M. et al. (1989) Idiotype networks in schistosomiasis. In New Strategies in Parasitology. K.P.W. McAdam, ed. Churchill Livingston., Edinburgh, p. 179
11. Fanning M.M., Peters P.A., Davis R.S., Kazura J.W. & Mahmoud A.A.F. (1981) Immunopathology of murine infection with Schistosoma mansoni: Relationship of genetic background to hepatosplenic disease and modulation. Journal of Infection Diseases 144, 148
12. Flores Villanueva P.O., Chikunguwo S.M., Harris T.S. & Stadecker M.J. (1993) Role of IL-10 on antigen-presenting cell function for schistosomal egg-specific monoclonal T helper cell responses in vitro and in vivo. Journal of Immunology 151, 3192
13. Flores Villanueva P.O., Harris T.S., Ricklan D.E. & Stadecker M.J. (1994) Macrophages from schistosomal egg granulomas induce unresponsiveness in specific clone Th1 lymphocytes in vitro and down-regulate schistosomal granulomatous disease in vivo. Journal of Immunology 152, 1847
14. Flores Villanueva P.O., Reiser H. & Stadecker M.J. (1994) Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10: effect on expression of B7 and B7-2 costimulatory molecules by macrophages. Journal of Immunology 153, 5190
15. Flores Villanueva P.O., Zheng X.X., Strom T.B. & Stadecker M.J. (1996) Recombinant IL-10 and IL-10/Fc treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis. Journal of Immunology 156, 3315
16. Hernandez H., Wang H.Y., Tzellas N. & Stadecker M.J. (1997) Expression of class II, but not class I, major histocompatibility complex molecules is required for granuloma formation in infection with Schistosoma mansoni. European Journal of Immunology 27, 1170
17. + T helper cell response to dominant epitope peptide of major egg antigen Sm-p40. Experimental Pathology (in press).
18. Hernandez H.J., Trzyna W.C., Cordingley J.S., Brodeur P.H. & Stadecker M.J. (1997) Differential antigen recognition by T cell populations from strains of mice developing polar forms of granulomatous inflammation in response to eggs of Schistosoma mansoni. European Journal of Immunology 27, 666
19. Hernandez H.J., Wang Y. & Stadecker M.J. (1997) In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granulomas formation. Journal of Immunology 158, 4832
20. Iacomini J., Ricklan D.E. & Stadecker M.J. (1995) T cells expressing the 76 T cell receptor are not required for egg granuloma formation in schistosomiasis. European Journal of Immunology 25, 884
21. King C.L., Medhat A., Malhotra I. et al. (1996) Cytokine control of parasite-specific anergy in human urinary schistosomiasis. Journal of Immunology 156, 4715
22. Mahanty S. & Nutman T.B. (1995) Immunoregulation in human filariasis: The role of interleukin 10. Parasite Immunology 17, 385
23. Malaquias L.C.C., Falcao P.L., Correa Oliveira R. & Wilson R.A. (1997) IL-10 is an important factor in controlling morbidity in schistosomiasis mansoni (abstract IMM03). International Symposium on Schistosomiasis, Belo Horizonte, Brazil, 1997
24. Mosmann T.R. & Coffman R.L. (1989) TH-1 and TH-2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology 7, 145
25. Nene V., Dunne D.W., Johnson K.S., Taylor D.W. & Cordingley J.S. (1986) Sequence and expression of a major egg antigen from Schistosoma mansoni. Homologies to heat shock proteins and alpha-crystallins. Molecular and Biochemical Parasitotogy 21, 179
26. Pearce E.J., Caspar P., Grzych J.M., Lewis F.A. & Sher A. (1991) Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. Journal of Experimental Medicine 173, 159
27. Perrin P.J. & Phillips S.M. (1989) The molecular basis of granuloma formation in schistosomiasis. III. In vivo effects of a T cell-derived suppressor-effector factor and IL-2 on granuloma formation. Journal of Immunology 143, 649
28. Phillips S., Di Conza J.J., Gold J.A. & Reid W.A. (1977) Schistosomiasis in the congenitally athymic (nude) mouse. I. Thymic dependency of eosinophilia, granuloma formation and host morbidity. Journal of Immunology 118, 594
29. Stadecker M.J. & Flores Villanueva P.O. (1994) Accessory cell signals regulate Th-cell responses: from basic immunology to a model of helminthic disease. Immunology Today 15, 571
30. Wynn T.A., Eltoum I., Oswald I.P., Cheever A.W. & Sher A. (1994) Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. Journal of Experimental Medicine 179, 1551