Fibroblasts as sentinel cells: Role of the CD40-CD40 ligand system in fibroblast activation and lung inflammation and fibrosis

Chest

Volumn 120, Issue , 2001, Pages 53S-55S

  Kaufman, Julia ^a   Graf, Beth A ^a   Leung, Edmund C ^a   Pollock, Stephen J ^a   Koumas, Timothy M ^a   Reddy, Sireesha Y ^a   Blieden, Timothy M ^a   Smith, Terry J ^a   Phipps, Richard P ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CELL ADHESION MOLECULE; CHEMOKINE; CYCLOOXYGENASE 2; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN GP 39; HYALURONIC ACID; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; PROSTAGLANDIN; SCLEROPROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CELL ACTIVATION; CONFERENCE PAPER; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; EPITHELIUM CELL; HUMAN; IMMUNOCOMPETENT CELL; LUNG FIBROBLAST; LUNG FIBROSIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR FORMATION; SIGNAL TRANSDUCTION; TISSUE REPAIR; WOUND HEALING;

CD40 LIGAND; FIBROBLASTS; HUMANS; LUNG; MAST CELLS; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0034916092     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.120.1_suppl.S53     Document Type: Article

References (12)

1. CD40-CD40 ligand
2. CD40 expression by human fibroblasts
3. Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism
4. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
5. CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts
6. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation
7. CD40 mediated activation of gingival and periodontal ligament fibroblasts
8. Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression
9. Interleukin-6 is an autocrine growth factor for murine lung fibroblast subsets
10. CD40 function in nonhematopoietic cells
11. Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome
12. Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis