메뉴 건너뛰기




Volumn 172, Issue 3, 2004, Pages 1380-1390

Tc1 and Tc2 Effector Cell Therapy Elicit Long-Term Tumor Immunity by Contrasting Mechanisms That Result in Complementary Endogenous Type 1 Antitumor Responses

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; LYMPHOCYTE SURFACE MARKER; OVALBUMIN; PERFORIN;

EID: 1642567230     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.3.1380     Document Type: Article
Times cited : (60)

References (62)
  • 3
    • 0037058993 scopus 로고    scopus 로고
    • Adoptive T cell therapy using antigen-specific CD8 T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
    • Yee, C., J. A. Thompson, D. Bryd, S. R. Ridell, P. Roche, E. Celis, and P. D. Greenberg. 2002. Adoptive T cell therapy using antigen-specific CD8 T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells. Proc. Natl. Acad. Sci. USA 99:16168.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16168
    • Yee, C.1    Thompson, J.A.2    Bryd, D.3    Ridell, S.R.4    Roche, P.5    Celis, E.6    Greenberg, P.D.7
  • 5
    • 0033558363 scopus 로고    scopus 로고
    • Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
    • Yee, C., P. A. Savage, P. P. Lee, M. M. Davis, and P. D. Greenberg. 1999. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J. Immunol. 162:2227.
    • (1999) J. Immunol. , vol.162 , pp. 2227
    • Yee, C.1    Savage, P.A.2    Lee, P.P.3    Davis, M.M.4    Greenberg, P.D.5
  • 9
    • 0036593490 scopus 로고    scopus 로고
    • Modulating T cell immunity to tumors: New strategies for monitoring T cell responses
    • Yee, C., and P. Greenberg. 2002. Modulating T cell immunity to tumors: new strategies for monitoring T cell responses. Nat. Rev. Cancer 2:409.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 409
    • Yee, C.1    Greenberg, P.2
  • 11
    • 0027056895 scopus 로고
    • Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
    • Mizoguchi, H., J. J. O'Shea, D. L. Longo, C. M. Loeffler, D. W. McVicar, and A. C. Ochoa. 1992. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 258:1795.
    • (1992) Science , vol.258 , pp. 1795
    • Mizoguchi, H.1    O'Shea, J.J.2    Longo, D.L.3    Loeffler, C.M.4    McVicar, D.W.5    Ochoa, A.C.6
  • 12
    • 0031157453 scopus 로고    scopus 로고
    • Sequential development of structural and functional alterations in T cells from tumor-bearing mice
    • Correa, M. R., A. C. Ochoa, P. Ghosh, H. Mizoguchi, L. Harvey, and D. L. Longo. 1997. Sequential development of structural and functional alterations in T cells from tumor-bearing mice. J. Immunol. 158:5292.
    • (1997) J. Immunol. , vol.158 , pp. 5292
    • Correa, M.R.1    Ochoa, A.C.2    Ghosh, P.3    Mizoguchi, H.4    Harvey, L.5    Longo, D.L.6
  • 14
    • 0036167033 scopus 로고    scopus 로고
    • CD94-NKG2A receptors regulate antiviral CD8 T cell responses
    • Moser, J. M., J. Gibbs, P. E. Jensen, and A. E. Lukacher. 2002. CD94-NKG2A receptors regulate antiviral CD8 T cell responses. Nat. Immunol. 3:189.
    • (2002) Nat. Immunol. , vol.3 , pp. 189
    • Moser, J.M.1    Gibbs, J.2    Jensen, P.E.3    Lukacher, A.E.4
  • 15
    • 0036467459 scopus 로고    scopus 로고
    • Activation-induced nonresponsiveness: A Th-dependent regulatory checkpoint in the CTL response
    • Tham, E. L., P. Shrikant, and M. F. Mescher. 2002. Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL response. J. Immunol. 168:1190.
    • (2002) J. Immunol. , vol.168 , pp. 1190
    • Tham, E.L.1    Shrikant, P.2    Mescher, M.F.3
  • 18
    • 0030293623 scopus 로고    scopus 로고
    • Isolation of tyrosinase-specific CD8 and CD4 T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus
    • Yee, C., M. J. Gilbert, S. R. Riddell, V. G. Brichard, A. Fefer, J. A. Thompson, T. Boon, and P. D. Greenberg. 1996. Isolation of tyrosinase-specific CD8 and CD4 T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus. J. Immunol. 157:4079.
    • (1996) J. Immunol. , vol.157 , pp. 4079
    • Yee, C.1    Gilbert, M.J.2    Riddell, S.R.3    Brichard, V.G.4    Fefer, A.5    Thompson, J.A.6    Boon, T.7    Greenberg, P.D.8
  • 20
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumor immunology and immunotherapy
    • Rosenberg, S. A. 2001. Progress in human tumor immunology and immunotherapy. Nature 411:380.
    • (2001) Nature , vol.411 , pp. 380
    • Rosenberg, S.A.1
  • 21
    • 0037111530 scopus 로고    scopus 로고
    • Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor infiltrating lymphocytes from a patient with melanoma
    • Robbins, P. F., M. El-Gamil, Y. F. Li, G. Zeng, M. Dudley, and S. A. Rosenberg. 2002. Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor infiltrating lymphocytes from a patient with melanoma. J. Immunol. 169:6036.
    • (2002) J. Immunol. , vol.169 , pp. 6036
    • Robbins, P.F.1    El-Gamil, M.2    Li, Y.F.3    Zeng, G.4    Dudley, M.5    Rosenberg, S.A.6
  • 22
    • 0034668011 scopus 로고    scopus 로고
    • Divergent roles for CD4 T cells in the priming and effector/memory phases of adoptive immunotherapy
    • Hu, H., H. Winter, W. J. Urba, and B. A. Fox. 2000. Divergent roles for CD4 T cells in the priming and effector/memory phases of adoptive immunotherapy. J. Immunol. 165:4246.
    • (2000) J. Immunol. , vol.165 , pp. 4246
    • Hu, H.1    Winter, H.2    Urba, W.J.3    Fox, B.A.4
  • 23
    • 0037220470 scopus 로고    scopus 로고
    • Human CD4 T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-γ
    • Hess, S. D., N. K. Egilmez, N. Bailey, T. M. Anderson, E. Mathiowitz, S. H. Bernstein, and R. B. Bankert. 2003. Human CD4 T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-γ. J. Immunol. 170:400.
    • (2003) J. Immunol. , vol.170 , pp. 400
    • Hess, S.D.1    Egilmez, N.K.2    Bailey, N.3    Anderson, T.M.4    Mathiowitz, E.5    Bernstein, S.H.6    Bankert, R.B.7
  • 27
    • 0028020588 scopus 로고
    • Generation of polarized antigen specific CD8 effector populations: Reciprocal actions of IL-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
    • Croft, M., L. L. Carter, S. L. Swain, and R. W. Dutton. 1994. Generation of polarized antigen specific CD8 effector populations: reciprocal actions of IL-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med. 180:1715.
    • (1994) J. Exp. Med. , vol.180 , pp. 1715
    • Croft, M.1    Carter, L.L.2    Swain, S.L.3    Dutton, R.W.4
  • 28
    • 0030175602 scopus 로고    scopus 로고
    • Type 1 and type 2: A fundamental dichotomy for all T cell subsets
    • Carter, L. L., and R. W. Dutton. 1996. Type 1 and type 2: a fundamental dichotomy for all T cell subsets. Curr. Opin. Immunol. 8:336.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 336
    • Carter, L.L.1    Dutton, R.W.2
  • 29
    • 0028960040 scopus 로고
    • Cytokine induced differentiation of precursor mouse CD8 T cells into cytotoxic CD8 T cells secreting th1 or th2 cytokines
    • Sad, S., R. Marcotte, and T. R. Mosmann. 1995. Cytokine induced differentiation of precursor mouse CD8 T cells into cytotoxic CD8 T cells secreting th1 or th2 cytokines. Immunity 2:271.
    • (1995) Immunity , vol.2 , pp. 271
    • Sad, S.1    Marcotte, R.2    Mosmann, T.R.3
  • 30
    • 0033970454 scopus 로고    scopus 로고
    • Human Tc1 and Tc2/Tc0 CD8 T cell clones display distinct cell surface and functional phenotypes
    • Vukmanovic-Stejic, M., B. Vyas, P. Gorak-Stolinska, A. Noble, and D. M. Kemeny. 2000. Human Tc1 and Tc2/Tc0 CD8 T cell clones display distinct cell surface and functional phenotypes. Blood 95:231.
    • (2000) Blood , vol.95 , pp. 231
    • Vukmanovic-Stejic, M.1    Vyas, B.2    Gorak-Stolinska, P.3    Noble, A.4    Kemeny, D.M.5
  • 33
    • 0030976897 scopus 로고    scopus 로고
    • Functional characterization and modulation of cytokine production by CD8 T cells from human immunodcficiency virus-infected individuals
    • Maggi, E., R. Manetti, F. Annunziato, L. Cosmi, M. G. Giudizi, R. Biagiotti, G. Galli, G. Zuccati, and S. Romagnani. 1997. Functional characterization and modulation of cytokine production by CD8 T cells from human immunodcficiency virus-infected individuals. Blood 89:3672.
    • (1997) Blood , vol.89 , pp. 3672
    • Maggi, E.1    Manetti, R.2    Annunziato, F.3    Cosmi, L.4    Giudizi, M.G.5    Biagiotti, R.6    Galli, G.7    Zuccati, G.8    Romagnani, S.9
  • 34
    • 0034650432 scopus 로고    scopus 로고
    • Type 1 and type 2 CD8 effector T cell subpopulations promote long-term tumor immunity and protection to progressively growing tumors
    • Dobrzanski, M. J., J. B. Reome, and R. W. Dutton. 2000. Type 1 and type 2 CD8 effector T cell subpopulations promote long-term tumor immunity and protection to progressively growing tumors. J. Immunol. 164:916.
    • (2000) J. Immunol. , vol.164 , pp. 916
    • Dobrzanski, M.J.1    Reome, J.B.2    Dutton, R.W.3
  • 39
    • 0142166426 scopus 로고    scopus 로고
    • Chemokines: Agents for immunotherapy of cancer
    • Homey, B., A. Muller, and A. Zlotnik. 2002. Chemokines: agents for immunotherapy of cancer. Nat. Rev. Immunol. 2:175.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 175
    • Homey, B.1    Muller, A.2    Zlotnik, A.3
  • 40
    • 0035399599 scopus 로고    scopus 로고
    • Role of effector cell-derived IL-4, IL-5, and perforin in early and late stages of type 2 CD8 effector cell-mediated tumor rejection
    • Dobrzanski, M. J., J. B. Reome, and R. W. Dutton. 2001. Role of effector cell-derived IL-4, IL-5, and perforin in early and late stages of type 2 CD8 effector cell-mediated tumor rejection. J. Immunol. 167:424.
    • (2001) J. Immunol. , vol.167 , pp. 424
    • Dobrzanski, M.J.1    Reome, J.B.2    Dutton, R.W.3
  • 41
    • 0035182194 scopus 로고    scopus 로고
    • Immunopotentiating role of IFN-γ in early and late stages of type 1 CD8 effector cell-mediated tumor rejection
    • Dobrzanski, M. J., J. B. Reome, and R. W. Dutton. 2001. Immunopotentiating role of IFN-γ in early and late stages of type 1 CD8 effector cell-mediated tumor rejection. Clin. Immunol. 98:70.
    • (2001) Clin. Immunol. , vol.98 , pp. 70
    • Dobrzanski, M.J.1    Reome, J.B.2    Dutton, R.W.3
  • 42
    • 0032853311 scopus 로고    scopus 로고
    • Tumor regression after adoptive transfer of effector T cells is independent of perforin or fas ligand (APO1L/CD95L)
    • Winter, H., H. Hu, W. J. Urba, and B. A. Fox. 1999. Tumor regression after adoptive transfer of effector T cells is independent of perforin or fas ligand (APO1L/CD95L). J. Immunol. 163:4462.
    • (1999) J. Immunol. , vol.163 , pp. 4462
    • Winter, H.1    Hu, H.2    Urba, W.J.3    Fox, B.A.4
  • 43
    • 0033830050 scopus 로고    scopus 로고
    • Differential requirements of perforin and IFN-γ in CD8 T cell-mediated immune responses against B16-F10 melanoma cells expressing a viral antigen
    • Prevost-Blondel, A., M. Neuenhahn, M. Rawiel, and H. Pircher. 2000. Differential requirements of perforin and IFN-γ in CD8 T cell-mediated immune responses against B16-F10 melanoma cells expressing a viral antigen. Eur. J. Immunol. 30:2507.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 2507
    • Prevost-Blondel, A.1    Neuenhahn, M.2    Rawiel, M.3    Pircher, H.4
  • 44
    • 0035500642 scopus 로고    scopus 로고
    • CD8 tumor infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis
    • Radoja, S., M. Saio, D. Schaer, M. Koneru, S. Vukmanovic, and A. B. Frey. 2001. CD8 tumor infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis. J. Immunol. 167:5042.
    • (2001) J. Immunol. , vol.167 , pp. 5042
    • Radoja, S.1    Saio, M.2    Schaer, D.3    Koneru, M.4    Vukmanovic, S.5    Frey, A.B.6
  • 45
    • 0037442189 scopus 로고    scopus 로고
    • Cutting edge: Perforin down-regulates CD4 and CD8 T cell-mediated immune responses to a transplanted organ
    • Bose, A., Y. Inoue, K. E. Kokko, and F. G. Lakkis. 2003. Cutting edge: perforin down-regulates CD4 and CD8 T cell-mediated immune responses to a transplanted organ. J. Immunol. 170:1611.
    • (2003) J. Immunol. , vol.170 , pp. 1611
    • Bose, A.1    Inoue, Y.2    Kokko, K.E.3    Lakkis, F.G.4
  • 48
    • 0032526906 scopus 로고    scopus 로고
    • A pathogenic role of Th2 cells and their cytokine products on the pulmonary metastases of murine B16 melanoma
    • Kobayashi, M., H. Kobayashi, R. B. Pollard, and F. Suzuki. 1998. A pathogenic role of Th2 cells and their cytokine products on the pulmonary metastases of murine B16 melanoma. J. Immunol. 160:5869.
    • (1998) J. Immunol. , vol.160 , pp. 5869
    • Kobayashi, M.1    Kobayashi, H.2    Pollard, R.B.3    Suzuki, F.4
  • 49
    • 0035451831 scopus 로고    scopus 로고
    • Predominant Th2/Tc2 polarity of tumor infiltrating lymphocytes in human cervical cancer
    • Sheu, B., R. Lin, H. Lien, H. Ho, S. Hsu, and S. Huang. 2001. Predominant Th2/Tc2 polarity of tumor infiltrating lymphocytes in human cervical cancer. J. Immunol. 167:2972.
    • (2001) J. Immunol. , vol.167 , pp. 2972
    • Sheu, B.1    Lin, R.2    Lien, H.3    Ho, H.4    Hsu, S.5    Huang, S.6
  • 50
    • 0034545618 scopus 로고    scopus 로고
    • Cutting edge: Spontaneous rejection of poorly immunogenic PI.HTR tumors by Stat6-deficient mice
    • Kacha, A. K., F. Fallarino, A. A. Markiewicz, and T. F. Gajewski. 2000. Cutting edge: spontaneous rejection of poorly immunogenic PI.HTR tumors by Stat6-deficient mice. J. Immunol. 165:6024.
    • (2000) J. Immunol. , vol.165 , pp. 6024
    • Kacha, A.K.1    Fallarino, F.2    Markiewicz, A.A.3    Gajewski, T.F.4
  • 51
    • 0034544609 scopus 로고    scopus 로고
    • Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma
    • Ostrand-Rosenberg, S., M. J. Grusby, and V. K. Clements. 2000. Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma. J. Immunol. 165:6015.
    • (2000) J. Immunol. , vol.165 , pp. 6015
    • Ostrand-Rosenberg, S.1    Grusby, M.J.2    Clements, V.K.3
  • 52
    • 0032530377 scopus 로고    scopus 로고
    • Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell responses from a type 2 to a type 1 cytokine profile
    • Hu, H., W. J. Urba, and B. A. Fox. 1998. Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell responses from a type 2 to a type 1 cytokine profile. J. Immunol. 161:3033.
    • (1998) J. Immunol. , vol.161 , pp. 3033
    • Hu, H.1    Urba, W.J.2    Fox, B.A.3
  • 53
    • 0032824424 scopus 로고    scopus 로고
    • Cutting edge: Differentiation of antitumor CTL in vivo requires host expression of Stat1
    • Fallarino, F., and T. F. Gajewski. 1999. Cutting edge: differentiation of antitumor CTL in vivo requires host expression of Stat1. J. Immunol. 163:4109.
    • (1999) J. Immunol. , vol.163 , pp. 4109
    • Fallarino, F.1    Gajewski, T.F.2
  • 55
    • 0037341335 scopus 로고    scopus 로고
    • Tumor-induced polarization of tumor vaccine-draining lymph node T cells to a type I cytokine profile predicts inherent strong immunogenicity of the tumor and correlates with therapeutic efficacy in adoptive transfer studies
    • Winter, H., H. M. Hu, C. H. Poehlein, E. Huntzicker, J. J. Osterholzer, J. Bashy, D. Lashley, B. Lowe, J. Yamada, G. Alvord, et al. 2003. Tumor-induced polarization of tumor vaccine-draining lymph node T cells to a type I cytokine profile predicts inherent strong immunogenicity of the tumor and correlates with therapeutic efficacy in adoptive transfer studies. Immunology 108:409.
    • (2003) Immunology , vol.108 , pp. 409
    • Winter, H.1    Hu, H.M.2    Poehlein, C.H.3    Huntzicker, E.4    Osterholzer, J.J.5    Bashy, J.6    Lashley, D.7    Lowe, B.8    Yamada, J.9    Alvord, G.10
  • 57
    • 0035340279 scopus 로고    scopus 로고
    • Prolonged exposure of T cells to TNF down-regulates TCR-ζ and expression of the TCR/CD3 complex at the cell surface
    • Isomaki, P., M. Panesar, A. Annenkov, J. M. Clark, B. M. J. Foxwell, Y. Chemajovsky, and A. P. Cope. 2001. Prolonged exposure of T cells to TNF down-regulates TCR-ζ and expression of the TCR/CD3 complex at the cell surface. J. Immunol. 166:5495-5507.
    • (2001) J. Immunol. , vol.166 , pp. 5495-5507
    • Isomaki, P.1    Panesar, M.2    Annenkov, A.3    Clark, J.M.4    Foxwell, B.M.J.5    Chemajovsky, Y.6    Cope, A.P.7
  • 58
    • 0033105809 scopus 로고    scopus 로고
    • Cancer dormancy: A regulatory role for CD8 T cells and IFN-γ in establishing and maintaining the tumor dormant state
    • Farrar, J. D., J. H. Katz, J. Windsor, G. Thrush, R. H. Scheuermann, J. W. Uhr, and N. E. Street. 1999. Cancer dormancy: a regulatory role for CD8 T cells and IFN-γ in establishing and maintaining the tumor dormant state. J. Immunol. 162:2842.
    • (1999) J. Immunol. , vol.162 , pp. 2842
    • Farrar, J.D.1    Katz, J.H.2    Windsor, J.3    Thrush, G.4    Scheuermann, R.H.5    Uhr, J.W.6    Street, N.E.7
  • 59
    • 0034669980 scopus 로고    scopus 로고
    • IFN-γ can promote tumor evasion of the immune system in vivo by down regulating cellular levels of an endogenous tumor antigen
    • Beatty, G. L., and Y. Paterson. 2000. IFN-γ can promote tumor evasion of the immune system in vivo by down regulating cellular levels of an endogenous tumor antigen. J. Immunol. 165:5502.
    • (2000) J. Immunol. , vol.165 , pp. 5502
    • Beatty, G.L.1    Paterson, Y.2
  • 60
    • 0036856108 scopus 로고    scopus 로고
    • IFN-γ suspends the killing license of anti-tumor CTLs
    • Lukacher, A. E. 2002. IFN-γ suspends the killing license of anti-tumor CTLs. J. Clin. Invest. 110:1407.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1407
    • Lukacher, A.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.