Predominant Th2/Tc2 polarity of tumor-infiltrating lymphocytes in human cervical cancer

Journal of Immunology

Volumn 167, Issue 5, 2001, Pages 2972-2978

  Sheu, B C ^a   Lin, R H ^a   Lien, H C ^a   Ho, H N ^a   Hsu, S M ^a   Huang, S C ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ARTICLE; CELL POLARITY; CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MOLECULAR CLONING; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; T LYMPHOCYTE SUBPOPULATION; TUMOR ASSOCIATED LEUKOCYTE; UTERINE CERVIX CANCER; UTERINE CERVIX EPITHELIUM;

EID: 0035451831     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.5.2972     Document Type: Article

References (46)

1. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
2. Biology of human Th1 and Th2 cells
3. Th1 and Th2 subsets: Paradigms lost?
4. The expanding universe of T-cell subsets: Th1, Th2 and more
5. Type 1 and type 2: A fundamental dichotomy for all T-cells
6. The Th1/Th2 paradigm
7. + T cells can be primed in vitro to produce 1L-4
8. + T cells secreting Th1 or Th2 cytokines
9. Functions of CD8 T-cell subsets secreting different cytokine patterns
10. In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines
11. CD8 Tc1 and Tc2 cells secret distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions
12. Relative perforin- and fas-mediated lysis in T1 and T2 CD8 effector populations
13. Migration kinetics and final destination of type 1 and type 2 CD8 effector cells predict protection against pulmonary virus infection
14. The host-tumor immune conflict: From immunosuppression to resistance and destruction
15. Proliferative and cytolytic potentials of purified human tumor-infiltrating T lymphocytes, impaired response to mitogen-driven stimulation despite T-cell receptor expression
16. Isolation and characterization of tumor-infiltrating lymphocytes from cervical carcinoma
17. Tumour-infiltrating lymphocytes in cervical carcinoma
18. + T lymphocytes are recruited to neoplastic cervix
19. Down-regulation of CD25 expression on activated tumor-infiltrating lymphocytes derived from human cervical carcinoma
20. Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes correlate with disease progression in human cervical cancer
21. Induction of tumor-specific T cell response by cognating tumor cells with foreign antigen-primed Th cells
22. Cytotoxic T lymphocyte activation by cross-priming
23. Detection of intracellular cytokines by flow cytometry
24. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells
25. A novel role of metalloproteinase in cancer-mediated immunosuppression
26. The tumor enhancement phenomenon: Reinterpretation from a Th1/Th2 perspective
27. Tumor-host interaction: Analysis of cytokines, growth factors, and tumor-infiltrating lymphocytes in ovarian carcinoma
28. Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression
29. The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor-infiltrating lymphocytes
30. Phenotypic alterations in fibroblasts and fibrosarcoma cells that overexpress latent transforming growth factor-β1
31. Increased transforming growth factor β expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A carcinoma cells
32. Study of tumor-infiltrating lymphocytes and transforming growth factor-β as prognostic factors in breast carcinoma
33. IL-10 production in cutaneous basal and squamous cell carcinomas: A mechanism for evading the local T cell immune response
34. Tumor immunology
35. Tumor-associated transforming growth factor-β and interleukin-10 contribute a systemic Th2 immune phenotype in pancreatic carcinoma patients
36. IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells
37. Human non-small cell lung cancer cells express a type 2 cytokine pattern
38. Host immune response in renal cell cancer: Interleukin-4 (IL-4) and IL-10 mRNA are frequently detected in freshly collected tumor-infiltrating lymphocytes
39. Interleukin-10: A cytokine used by tumors to escape immunosurveillance
40. + T cells resulting in a failure to lyse tumor cells
41. Regulatory effects of transforming growth factor-β on IL-2- and IL-4-dependent T cell-cycle progression
42. Effects of TGF-β on the immune system: Implications for cancer immunotherapy
43. A highly immunogenic tumor transfected with a murine transforming growth factor type β1 cDNA escapes immune surveillance
44. Transforming growth factor-β1, a strong costimulator of rat T-cell activation promoting a shift towards a Th2-like cytokine profile
45. TGF-β contributes to the shift toward Th2type responses through direct and IL-10-mediated pathways in tumor-bearing mice
46. A novel role for TGF-β and IL-10 in the induction of immune privilege