Differential requirement of perforin and IFN-γ in CD8 T cell-mediated immune responses against B16.F10 melanoma cells expressing a viral antigen

European Journal of Immunology

Volumn 30, Issue 9, 2000, Pages 2507-2515

  Prévost Blondel, Armelle ^a   Neuenhahn, Michael ^a   Rawiel, Marlies ^a   Pircher, Hanspeter ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

B16 melanoma; CD8 T cell; IFN ; Immunotherapy; Perforin

Indexed keywords

EPITOPE; GAMMA INTERFERON; MEGALIN; PERFORIN; T LYMPHOCYTE RECEPTOR; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER INHIBITION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FEMALE; IMMUNE RESPONSE; LYMPHOCYTE FUNCTION; MALE; MELANOMA CELL; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR IMMUNITY; TUMOR REGRESSION;

ADOPTIVE TRANSFER; ANIMAL; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; INTERFERON TYPE II; LUNG NEOPLASMS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MELANOMA, EXPERIMENTAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T;

EID: 0033830050     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200009)30:9<2507::AID-IMMU2507>3.0.CO;2-V     Document Type: Article

References (36)

1. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
2. Decreased tumor surveillance in perforin-deficient mice
3. Perforin and IFN-gamma are involved in the antitumor effects of antibody-target superantigens
4. Adoptive transfer: The role of perforin in mouse cytotoxic T lymphocyte reiection of human tumor xenografts in vivo
5. Perforin dependence of natural killer cell-mediated tumor control in vivo
6. Perforin is a major contributor to NK cell control of tumor metastasis
7. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12
8. + tumor-infiltrating lymphocytes
9. γ-Interferon plays a key role in T-cell-induced tumor regression
10. Successful adoptive cellular immunotherapy is dependent on induction of a host immune response triggered by cytokine (IFN-gamma and granulocyte/macrophage colony-stimulating factor) producing donor tumor-infiltrating lymphocytes
11. + T cells and IFN-γ in establishing and maintaining the tumor-dormant state
12. Demonstration of an interferon gamma-dependent tumor surveillance system of immunocompetent mice
13. Tumor-selective cytotoxic effects of routine tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) in organ culture of B16 melanoma cells in heart tissue
14. T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas
15. Cellular responses to interferon-gamma
16. The IFN gamma receptor: A paradigm for cytokine receptor signaling
17. Tumor-infiltrating lymphocytes exhibiting high ex vivo cytolytic activity fail to prevent murine melanoma tumor growth in vivo
18. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
19. Tumor regression after adoptive transfer of effector T cells is independent of perforin or Fas ligand (APO-1L/CD95L)
20. + effector T cell subpopulations promote long-term tumor immunity and protection to progressively growing tumor
21. Interferon-induced alterations in metastatic capacity, class-1 antigen expression and natural killer cell sensitivity of melanoma cells
22. A reassessment of the role of B7-1 expression in tumor rejection
23. Differentiation of antitumor CTL in vivo requires host expression of Stat1
24. In vivo elimination by specific effector cells on an established syngeneic rat moloney virus-induced sarcoma
25. Evidence for long-lasting tumor immunity in a syngeneic rat lymphoma model: Correlation of in vitro findings with in vivo observations
26. Specific adoptive immunotherapy mediated by tumor-draining lymph node cells sequentially activated with anti-CD3 and IL-2
27. Characterization of T lymphocytes mediating in vivo protection against RSV-induced murine sarcomas
28. Coupling and uncoupling of tumor immunity and autoimmunity
29. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells
30. T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides
31. + memory T cells in virus-infected host
32. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
33. T cell receptor antagonist peptides induce positive selection
34. Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunisation with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein
35. Selection of successive tumor lines for metastasis
36. Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D