Immunopotentiating role of IFN-γ in early and late stages of type 1 CD8 effector cell-mediated tumor rejection

Clinical Immunology

Volumn 98, Issue 1, 2001, Pages 70-84

  Dobrzanski, Mark J ^a   Reome, Joyce B ^a   Dutton, Richard W ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

Chemokines; Immunotherapy; Melanoma; Metastases; Tumor immunity

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; RANTES;

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CANCER MODEL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; IMMUNOPOTENTIATION; LUNG CANCER; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR REJECTION;

EID: 0035182194     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2000.4945     Document Type: Article

References (45)

1. A randomized phase I/II study of continuous versus intermittent intravenous interferon gamma in patients with metastatic melanoma
2. Phase II study of recombinant interferon-gamma in patients with disseminated malignant melanoma
3. Successful treatment of metastatic renal cell carcinoma with a biologically active dose of recombinant interferon-γ
4. Cellular responses to Interferon-γ
5. Interferon γ and tumor necrosis factor have a role in tumor regressions mediated by murine CD8 tumor-infiltrating lymphocytes
6. Enhanced expression of HLA molecules and stimulation of autologous human tumor infiltrating lymphocytes following transduction of melanoma cells with γ-interferon genes
7. Demonstration of an interferon-γ-dependent tumor surveillance system in immunocompetent mice
8. CD4 T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-γ
9. T cell-mediated, IFN-γ-facilitated rejection of murine B 16 melanomas
10. Growth control of melanoma cells and melanocytes by cytokines
11. IFN-γ-dependent delay of in vivo tumor progression by fas over expression on murine renal cancer cells
12. Interferon-γ (IFN-γ) induces programmed cell death in differentiated human leukemic B cell lines
13. A regulatory role for CD8 T cells and IFN-γ in establishing and maintaining the tumor dormant state
14. Interferon-γ induces the expression of p21waf-1 and arrests macrophage cell cycle, preventing induction of apoptosis
15. Evidence that GM-CSF factor and interferon-γ maintain the viability of human peripheral blood monocytes in part by their suppression of IL-10 production
16. Interferon-γ inhibits apoptotic cell death in B cell chronic lymphocytic leukemia
17. Wild-type p53-induced apoptosis in a burkitt lymphoma cell line is inhibited by interferon-γ
18. Immunological effects of treatment with sequential administration of recombinant interferon γ and a in patients with metastatic renal cell carcinoma during a phase I trial
19. A phase IA trial of sequential recombinant DNAproduced interferons: Combination recombinant interferon gamma and recombinant alpha in patients with metastatic renal cell carcinoma
20. In vivo effects of combination treatment with recombinant interferon-gamma and alpha in metastatic melanoma
21. Recent advances in the care of the patients with malignant melanoma
22. IFN-γ priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs
23. Tumor cell responses to IFN-γ affect tumorgenicity and response to IL-12 therapy and antiangiogenesis
24. Interaction between chemokines and other cytokines in host responses to tumor
25. Chemokine modulation of tumor cell physiology
26. The role of CCR 7 in Th1 and Th2 cell localization and delivery of B cell help in vivo
27. + T cell subpopulations in established pulmonary metastases
28. Type I and type 2 CD8 effector T cell subpopulations promote long-term tumor immunity and protection to progressively growing tumors
29. Generation of polarized antigen specific CD8 effector populations: Reciprocal actions of IL-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
30. Cytokine induced differentiation of precursor mouse CD 8 T cells into cytotoxic CD8 T cells secreting Th1 or Th2 cytokines
31. T cell receptor antagonistic peptides induce positive selection
32. Death inducing functions of ligands for the tumor necrosis factor family: A sanhedrin verdict
33. Adoptive T cell therapy of tumors: Mechanisms operative in the recognition and elimination of tumor cells
34. T cell memory
35. Perforin and Fas killing by CD 8 T cells limit their cytokine synthesis and proliferation
36. Relative perforin- and fas-mediated lysis in T 1 and T2 CD8 effector populations
37. Molecular mechanisms of immune-mediated lysis of murine renal cancer: Differential contributions of perforin-dependent versus Fas-mediated pathways in lysis by NK and T cells
38. IP-10 a C-X-C-chemokine, elicits a potent thymus-dependent antitumor response in rive
39. Tumor infiltration by monocytes and the antitumor effects of monocyte chemoattractant protein-1
40. Interferon-γ-induciable protein IP-10 (IP-10) is an angiostatic factor that inhibits human nonsmall cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases
41. Chemokines induce NK cell migration and enhances NK cell cytolytic activity via cellular degranulation
42. Migration kinetics and final destination of type i and type 2 CD8 effector cells predict protection against pulmonary virus infection
43. Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma
44. Tumors as a paradigm for the in vivo role of chemokines in leukocyte recruitment
45. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients