Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8+ T cells

Journal of Experimental Medicine

Volumn 194, Issue 12, 2001, Pages 1767-1775

  Schüler, Thomas ^a   Kammertoens, Thomas ^a   Preiss, Susanne ^a   Debs, Pierre ^a   Noben Trauth, Nancy ^b   Blankenstein, Thomas ^a,c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Cross priming; Cytotoxic T lymphocytes; Interleukin 4; Interleukin 4 (receptor) deficient mice; Tumor vaccination

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 4;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; CELL TRANSFER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD8; CARCINOMA, RENAL CELL; CYTOTOXICITY, IMMUNOLOGIC; INTERLEUKIN-4; KIDNEY NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, SCID; NEOPLASM TRANSPLANTATION; RECEPTORS, INTERLEUKIN-4; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035905317     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.12.1767     Document Type: Article

References (42)

1. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
2. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay
3. Constitutive class I-restricted exogenous presentation of self antigens in vivo
4. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
5. Cytotoxic T lymphocyte activation by cross-priming
6. - dendritic cells cross-prime cytotoxic T cells in vivo
7. Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo
8. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
9. + T cell help
10. + T-helper and a T-killer cell
11. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
12. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
13. T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice
14. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
15. Functional diversity of helper T lymphocytes
16. Cytokines induce the development of functionally heterogeneous T helper cell subsets
17. + T cells can be primed in vitro to produce IL-4
18. + T cells secreting Th1 or Th2 cytokines
19. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
20. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity
21. Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage
22. + and B lymphocytes in transplantation immunity. II. Augmented rejection of tumor allografts by mice lacking B cells
23. The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product
24. In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter
25. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line
26. + T cell IL-4 production is revealed in IL-4 receptor-deficient mice
27. T cell receptor antagonist peptides induce positive selection
28. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
29. Natural adjuvants: Endogenous activators of dendritic cells
30. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
31. Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: Pathway of presentation and regulation by cytokines
32. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
33. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
34. The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells
35. Interleukin-4-mediated tumor suppression in nude mice involves interferon-gamma
36. Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction
37. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells
38. + T helper type 1 cell responses to Candida albicans
39. A critical role for interleukin 4 in activating alloreactive CD4 T cells
40. + T cells mediate CD40-independent maturation of dendritic cells in vivo
41. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4
42. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells