Phenyl N-tert-butylnitrone down-regulates interleukin-1β-stimulated matrix metalloproteinase-13 gene expression in human chondrocytes: Suppression of c-Jun NH2-terminal kinase, p38-mitogen-activated protein kinase and activating protein-1

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 3, 2003, Pages 981-988

  Ahmed, Salahuddin ^a   Rahman, Ayesha ^b   Hasnain, Absarul ^b,c   Goldberg, Victor M ^a   Haqqi, Tariq M ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; N TERT BUTYL ALPHA PHENYLNITRONE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DNA BINDING; SIGNAL TRANSDUCTION;

CELLS, CULTURED; CHONDROCYTES; COLLAGENASES; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MATRIX METALLOPROTEINASE 13; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TRANSCRIPTION FACTOR AP-1;

EID: 0038814247     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.048611     Document Type: Article

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