Growth factor signaling in cell survival: Implications for cancer treatment

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 3, 2001, Pages 873-878

  Talapatra, Sunit ^a   Thompson, Craig B ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; GROWTH FACTOR RECEPTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; STAT PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER; CANCER THERAPY; CELL SURVIVAL; PLEIOTROPY; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; TREATMENT PLANNING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL SURVIVAL; GROWTH SUBSTANCES; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 0034883129     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (51)

1. A Phase I trial of the farnesyl transferase inhibitor SCH66336: Evidence for biological and clinical activity
2. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
3. Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1
4. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
5. Ras oncogenes in human cancer: A review
6. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
7. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
8. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
9. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
10. EB1089: A new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro
11. Size control in animal development
12. Human Bcl-2 antisense therapy for lymphomas
13. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
14. Interleukin-3 induced phosphorylation of BAD through the protein kinase Akt
15. Mitochondria as the central control point of apoptosis
16. The sevenless signaling cassette mediates Drosophila EGF receptor function during epidermal development
17. Impaired Fas response and autoimmunity in Pten+/- mice
18. Involvement of an ICE-like protease in Fas mediated apoptosis
19. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
20. A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer
21. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A
22. Bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair
23. Induction of NF-kappaB by the Akt/PKB kinase
24. Bcl-2-family proteins: The role of the BH3 domain in apoptosis
25. Ras promotes cell survival in Drosophila by down-regulating hid expression
26. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
27. Ras farnesyltransferase: A new therapeutic target
28. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis
29. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
30. Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53
31. Dying like flies
32. Expression of bcl-xL can confer a multidrug resistance phenotype
33. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
34. Induction of apoptosis by vitamin D3 analogue EB1089 in NCI-H929 myeloma cells via activation of caspase 3 and p38 MAP kinase
35. L promote growth factor-independent survival through distinct effects on mitochondrial physiology
36. Ras1 promotes cellular growth in the Drosophila wing
37. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein
38. NF-kappaB is a target of AKT in antiapoptotic PDGF signaling
39. Rsk1 mediates a MEKMAP kinase cell survival signal
40. Use of pharmacological agents in elucidating the mechanism of insulin action
41. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
42. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
43. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
44. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
45. Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
46. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma
47. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
48. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
49. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils
50. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
51. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3