Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphine

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 3, 2003, Pages 1299-1306

  Garnier, Martine ^a,b   Zaratin, Paola F ^a,b   Ficalora, Giovanna ^a,b   Valente, Maurizio ^a,b   Fontanella, Laura ^a,b   Rhee, Man Hee ^c   Blumer, Kendall J ^c   Scheideler, Mark A ^a,b,d  

^a GSK   (Italy)

^b Neurol Ctr Excellence Drug Discov   (United Kingdom)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MDS Proteomics A/S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 PYRROLIDINYLMETHYL) 1 (4 TRIFLUOROMETHYLPHENYL)ACETYL PIPERIDINE HYDROCHLORIDE; ADENYLATE CYCLASE INHIBITOR; BRL 52656; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOBUTYLMETHYLXANTHINE; ISOPROTEIN; MESSENGER RNA; MORPHINE; MORPHINE DERIVATIVE; MU OPIATE RECEPTOR; OPIATE AGONIST; PIPERIDINE DERIVATIVE; POLY DEXTRO LYSINE; RGS PROTEIN; RGS4 PROTEIN; UNCLASSIFIED DRUG;

ANALGESIA (SENSORY DYSFUNCTION); ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CHRONIC PAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPERALGESIA; HYPOTHESIS; IN SITU HYBRIDIZATION; INHIBITION KINETICS; LIGATION; LUMBAR SPINE; MALE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; RGS GENE; RNA ANALYSIS; SCIATIC NERVE; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

ANIMALS; HEAT; HYPERALGESIA; MALE; MORPHINE; PAIN; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; RGS PROTEINS; SCIATIC NERVE; SIGNAL TRANSDUCTION; SPINAL CORD; UP-REGULATION;

EID: 0037371746     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.043471     Document Type: Article

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