A four-ligand hypercube model to quantify allosteric interactions within the GABAA receptor complex

European Journal of Pharmacology

Volumn 485, Issue 1-3, 2004, Pages 43-51

  Van Rijn, Clementina M ^a   Willems Van Bree, Elly ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

GABAA receptor complex; Isobole method; Molecular model; Neuroactive steroid; Retigabine; Synergy; TBOB

Indexed keywords

(2BETA,3ALPHA,5ALPHA) 21 HYDROXY 3 HYDROXY 2 (4 MORPHOLINYL)PREGNAN 20 ONE METHANE SULFONATE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ANTICONVULSIVE AGENT; LIGAND; ORG 20549; RETIGABINE; STEROID; TERT BUTYLBICYCLOORTHOBENZOATE; TRITIUM; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; LIGAND BINDING; MODEL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 1642456609     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2003.11.044     Document Type: Article

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