A molecular model for the synergic interaction between γ-aminobutyric acid and general anaesthetics

European Journal of Pharmacology

Volumn 371, Issue 2-3, 1999, Pages 213-226

  Van Rijn, Clementina M ^a   Willems van Bree, Elly ^a   Zwart, Jan Pieter C ^a   Rodrigues De Miranda, Jaap F ^b   Dirksen, Ris ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Anaesthetic; GABA(A) receptor complex; Isobole method; Molecular model; Polytherapy; Synergy; TBOB (t butylbicycloorthobenzoate)

Indexed keywords

21 CHLORO 3ALPHA HYDROXY 2BETA MORPHOLINO 5ALPHA PREGNAN 20 ONE METHANESULFONATE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; BENZOIC ACID DERIVATIVE; ORG 20549; PROPOFOL; THIOPENTAL; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; FOREBRAIN; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RAT;

ALLOSTERIC SITE; ANESTHETICS, GENERAL; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GAMMA-AMINOBUTYRIC ACID; MODELS, MOLECULAR; PROSENCEPHALON; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 0032911466     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00178-8     Document Type: Article

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