Sphingosine modulates myocyte electrophysiology, induces negative inotropy, and decreases survival after myocardial ischemia

Journal of Cardiovascular Pharmacology

Volumn 39, Issue 1, 2002, Pages 18-28

  Friedrichs, G S ^a   Swillo, R E ^a   Jow, B ^a   Bridal, T ^a   Numann, R ^a   Warner, L M ^a   Killar, L M ^a   Sidek, K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Inflammation; Ischemia; Myocardial infarction; Reperfusion; Sphingosine

Indexed keywords

ACYLSPHINGOSINE DEACYLASE; CALCIUM CHANNEL L TYPE; CERAMIDE; N OLEOYLETHANOLAMINE; SPHINGOSINE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR BINDING PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CAT; CELL SURVIVAL; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; HEART FAILURE; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; INFLAMMATION; INOTROPISM; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM;

ACTION POTENTIALS; AMIDOHYDROLASES; ANIMALS; CALCIUM; CATS; DEPRESSION, CHEMICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHANOLAMINES; FEMALE; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOSINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036139054     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200201000-00003     Document Type: Article

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