Troglitazone attenuates high-glucose-induced abnormalities in relaxation and intracellular calcium in rat ventricular myocytes

Diabetes

Volumn 45, Issue 12, 1996, Pages 1822-1825

  Ren, Jun ^a   Dominguez, Ligia J ^a   Sowers, James R ^a   Davidoff, Amy J ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; FURA 2 ACETOXYMETHYL ESTER; GLUCOSE; INSULIN; LAMININ; TROGLITAZONE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; EXCITATION CONTRACTION COUPLING; HEART MUSCLE RELAXATION; HEART PROTECTION; HEART VENTRICLE WALL; HYPERGLYCEMIA; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

EID: 0029912067     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.12.1822     Document Type: Article

References (23)

1. Galderisi M, Anderson KM, Wilson PWF, Levy D: Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study). Am J Cardiol 68:85-89, 1991
2. Rodrigues B, McNeill JH: The diabetic hearts: metabolic causes for the development of a cardiomyopathy. Cardiovasc Res 26:913-922, 1992
3. 2+] and pH in rat skinned cardiac myocytes. Am J Physiol 269:H1656-H1663, 1993
4. Davidoff AJ, Ren J: Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes. Am J Physiol. In press
5. Ren J, Davidoff AJ: High glucose mimics diabetes by producing abnormal relaxation in adult rat cardiac myocytes (Abstract). J Mol Cell Cardiol 28:A182, 1996
6. Suter SL, Nolan JJ, Wallace P, Gumbiner B, Olefsky JM: Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care 15:193-203, 1992
7. Lee M, Miles PDG, Khoursheed M, Gao K, Moosa AR, Olefsky J: Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes 43:1435-1439, 1994
8. Mimura K, Umeda F, Hiramatsu S, Taniguchi S, Ono Y, Nakashima N, Kobayashi K, Masakado M, Sako Y, Nawata H: Effects of a new oral hypoglycaemic agent (CS-045) on metabolic abnormalities and insulin resistance in type 2 diabetes. Diabetic Med 11:685-691, 1994
9. Ciaraldi TP, Gilmore A, Olefsky JM, Goldberg M, Heidenreich KA: In vitro studies on the action of CS-045, a new antidiabetic agent. Metabolism 39:1056-1062, 1990
10. Kellerer M, Kroder G, Tippmer S, Berti L, Kiehn R, Mosthaf L, Häring H: Troglitazone prevents glucose-induced insulin resistant of insulin receptor in rat-1 fibroblasts. Diabetes 43:447-453, 1994
11. Zhang F, Sowers JR, Ram JL, Standley PR, Peuler JD: Effects of pioglitazone on calcium channels in vascular smooth muscle. Hypertension 24:170-175, 1994
12. Walsh MF, Barazi M, Syed A, Igwe R, Zhang F, Sowers JR: Troglitazone induces both immediate and delayed relaxation in rat tail arteries (Abstract). Proc Int Congress Endo 2:969, 1996
13. Ren J, Davidoff AJ: Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes. Am J Physiol. In press
14. Borzak S, Murphy S, Marsh JD: Mechanisms of rate staircase in rat ventricular cells. Am J Physiol 260:H884-H892, 1991
15. Lee TS, Saltsman KS, Ohashi S, King JL: Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc Natl Acad Sci USA 86:5141-5145, 1989
16. Ruderman RB, Williamson JR, Brownlee M: Glucose and diabetic vascular disease. FASEB J 6:2905-2914, 1992
17. 2+] in rat aortic smooth muscle cells. Diabetes 43:1033-1040, 1994
18. Barbagallo M, Shan J, Pang PKT, Resnick LM: Glucose-induced alterations of cytosolic free calcium in cultured rat tail artery vascular smooth muscle cells. J Clin Invest 95:763-767, 1995
19. 19F nuclear magnetic resonance studies of free calcium in heart cells. Biophys J 65:2547-2558, 1993
20. Brown RA, Lee MM, Sundareson AM, Woodbury DJ, Savage AO: Influence of calcium channel blocker treatment on the mechanical properties of diabetic rat myocardium. Acta Diabetol 33:7-14, 1996
21. Afzal N, Ganfuly PK, Dhalla KS, Pierce GN, Singal PK, Dhalla N: Beneficial effects of verapamil in diabetic cardiomyopathy. Diabetes 37:936-942, 1988
22. Buchanan TA, Meehan WP, Jeng YY, Yang D, Chan TM, Nadler JL, Scott S, Rude RK, Hsueh WA: Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect. J Clin Invest 96:354-360, 1995
23. Barry WH, Bridge JHB: Intracellular calcium homeostasis in cardiac myocytes. Circulation 87:1806-1815, 1993