PIKE GTPase: A novel mediator of phosphoinositide signaling

Journal of Cell Science

Volumn 117, Issue 2, 2004, Pages 155-161

  Ye, Keqiang ^a   Snyder, Solomon H ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4.1N; ArfGAP; GEF; GTPase; PI 3 kinase; PIKE; PLC 1

Indexed keywords

ANKYRIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; ISOENZYME; METABOTROPIC RECEPTOR; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITIDE 3 KINASE ENHANCER; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHOLIPASE C; PLECKSTRIN; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL NUCLEUS; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; INTRACELLULAR SPACE; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BRAIN; CELL NUCLEUS; ENZYME ACTIVATION; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; ISOENZYMES; LIPID METABOLISM; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; RECEPTORS, GLUTAMATE; SIGNAL TRANSDUCTION;

EID: 1642421383     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00924     Document Type: Article

References (59)

1. Aiba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., Zwingman, T. A. and Tonegawa, S. (1994). Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79, 377-388.
2. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B. and Cohen, P. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7, 261-269.
3. Bacqueville, D., Deleris, P., Mendre, C., Pieraggi, M. T., Chap, H., Guillon, G., Perret, B. and Breton-Douillon, M. (2001). Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei. J. Biol. Chem. 276, 22170-22176.
4. Bae, Y. S., Cantley, L. G., Chen, C. S., Kim, S. R., Kwon, K. S. and Rhee, S. G. (1998). Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273, 4465-4469.
5. Batty, I. H., Hickinson, D. M. and Downes, C. P. (1997). Cross-talk between phospholipase C and phosphoinositide 3-kinase signalling pathways. Biochem. Soc. Trans. 25, 1132-1137.
6. Bavelloni, A., Santi, S., Sirri, A., Riccio, M., Faenza, I., Zini, N., Ceechi, S., Ferri, A., Auron, P., Maraldi, N. M. et al. (1999). Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells. J. Cell Sci. 112, 631-640.
7. Bertagnolo, V., Mazzoni, M., Ricci, D., Carini, C., Neri, L. M., Previati, M. and Capitani, S. (1995). Identification of PI-PLC beta 1, gamma 1, and delta 1 in rat liver: subcellular distribution and relationship to inositol lipid nuclear signalling. Cell. Signal. 7, 669-678.
8. Bertagnolo, V., Marchisio, M., Volinia, S., Caramelli, E. and Capitani, S. (1998). Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells. FEBS Lett. 441, 480-484.
9. Biederer, T. and Sudhof, T. C. (2001). CASK and protein 4.1 support F-actin nucleation on neurexins. J. Biol. Chem. 276, 47869-47876.
10. Boguski, M. S. and McCormick, F. (1993). Proteins regulating Ras and its relatives. Nature 366, 643-654.
11. Carpenter, G. and Ji, Q. (1999). Phospholipase C-gamma as a signal-transducing element. Exp. Cell Res. 253, 15-24.
12. Cherfils, J. and Chardin, P. (1999). GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem. Sci. 24, 306-311.
13. Cocco, L., Martelli, A. M., Gilmour, R. S., Rhee, S. G. and Manzoli, F. A. (2001). Nuclear phospholipase C and signaling. Biochim. Biophys. Acta 1530, 1-14.
14. Copani, A., Bruno, V. M., Barresi, V., Battaglia, G., Condorelli, D. F. and Nicoletti, F. (1995). Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture. J. Neurochem. 64, 101-108.
15. Cukierman, E., Huber, I., Rotman, M. and Cassel, D. (1995). The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Science 270, 1999-2002.
16. D'Santos, C. S., Clarke, J. H. and Divecha, N. (1998). Phospholipid signalling in the nucleus. Een DAG uit het leven van de inositide signalering in de nucleus. Biochim. Biophys. Acta 1436, 201-232.
17. De Blasi, A., Conn, P. J., Pin, J. and Nicoletti, F. (2001). Molecular determinants of metabotropic glutamate receptor signaling. Trends Pharmacol. Sci. 22, 114-120.
18. Diakonova, M., Chilov, D., Arnaoutov, A., Alexeyev, V., Nikolsky, N. and Medvedeva, N. (1997). Intracellular distribution of phospholipase C gamma 1 in cell lines with different levels of transformation. Eur. J. Cell Biol. 73, 360-367.
19. Divecha, N., Banfic, H. and Irvine, R. F. (1991). The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus. EMBO J. 10, 3207-3214.
20. Donaldson, J. G. (2000). Filling in the GAPs in the ADP-ribosylation factor story. Proc. Natl. Acad. Sci. USA 97, 3792-3794.
21. Frech, M., Andjelkovic, M., Ingley, E., Reddy, K. K., Falck, J. R. and Hemmings, B. A. (1997). High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J. Biol. Chem. 272, 8474-8481.
22. Girault, J. A., Labesse, G., Mornon, J. P. and Callebaut, I. (1999). The N-termini of FAK and JAKs contain divergent band 4.1 domains. Trends Biochem. Sci. 24, 54-57.
23. Hsueh, Y. P. and Sheng, M. (1999). Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J. Neurosci. 19, 7415-7425.
24. Huang, P. S., Davis, L., Huber, H., Goodhart, P. J., Wegrzyn, R. E., Oliff, A. and Heimbrook, D. C. (1995). An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-gamma 1. FEBS Lett. 358, 287-292.
25. Kim, S. J. (1998). Insulin rapidly induces nuclear translocation of PI3-kinase in HepG2 cells. Biochem. Mol. Biol. Int. 46, 187-196.
26. Lu, P. J., Hsu, A. L., Wang, D. S., Yan, H. Y., Yin, H. L. and Chen, C. S. (1998). Phosphoinositide 3-kinase in rat liver nuclei. Biochemistry 37, 5738-5745.
27. Lu, Y. M., Jia, Z., Janus, C., Henderson, J. T., Gerlai, R., Wojtowicz, J. M. and Roder, J. C. (1997). Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 17, 5196-5205.
28. Maraldi, N. M., Zini, N., Santi, S. and Manzoli, F. A. (1999). Topology of inositol lipid signal transduction in the nucleus. J. Cell Physiol. 181, 203-217.
29. Marchisio, M., Bertagnolo, V., Colamussi, M. L., Capitani, S. and Neri, L. M. (1998). Phosphatidylinositol 3-kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation. Biochem. Biophys. Res. Commun. 253, 346-351.
30. Marmiroli, S., Ognibene, A., Bavelloni, A., Cinti, C., Cocco, L. and Maraldi, N. M. (1994). Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells. J. Biol. Chem. 269, 13-16.
31. Martelli, A. M., Billi, A. M., Gilmour, R. S., Neri, L. M., Manzoli, L., Ognibene, A. and Cocco, L. (1994). Phosphoinositide signaling in nuclei of Friend cells: phospholipase C beta down-regulation is related to cell differentiation. Cancer Res. 54, 2536-2540.
32. Mattagajasingh, S. N., Huang, S. C., Hartenstein, J. S., Snyder, M., Marchesi, V. T. and Benz, E. J. (1999). A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein. J. Cell Biol. 145, 29-43.
33. Matteucci, A., Faenza, I., Gilmour, R. S., Manzoli, L., Billi, A. M., Peruzzi, D., Bavelloni, A., Rhee, S. G. and Cocco, L. (1998). Nuclear but not cytoplasmic phospholipase C beta 1 inhibits differentiation of erythroleukemia cells. Cancer Res. 58, 5057-5060.
34. Neri, L. M., Milani, D., Bertolaso, L., Stroscio, M., Bertagnolo, V. and Capitani, S. (1994). Nuclear translocation of phosphatidylinositol 3-kinase in rat pheochromocytoma PC 12 cells after treatment with nerve growth factor. Cell. Mol. Biol. (Noisy-le-grand) 40, 619-626.
35. Neri, L. M., Ricci, D., Carini, C., Marchisio, M., Capitani, S. and Bertagnolo, V. (1997). Changes of nuclear PI-PLC gamma1 during rat liver regeneration. Cell. Signal. 9, 353-362.
36. Neri, L. M., Borgatti, P., Capitani, S. and Martelli, A. M. (1998). Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-alpha. J. Biol. Chem. 273, 29738-29744.
37. Neri, L. M., Martelli, A. M., Borgatti, P., Colamussi, M. L., Marchisio, M. and Capitani, S. (1999). Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF-treated PC12 cells. FASEB J. 13, 2299-2310.
38. Ohara, R., Yamakawa, H., Nakayama, M., Yuasa, S. and Ohara, O. (1999). Cellular and subcellular localization of a newly identified member of the protein 4.1 family, brain 4.1, in the cerebellum of adult and postnatally developing rats. Brain Res. Dev. Brain Res. 117, 127-138.
39. 2+? Bioessays 20, 516-521.
40. Payrastre, B., Nievers, M., Boonstra, J., Breton, M., Verkleij, A. J. and van Bergen en Henegouwen, P. M. (1992). A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix. J. Biol. Chem. 267, 5078-5084.
41. Quilliam, L. A., Khosravi-Far, R., Huff, S. Y. and Der, C. J. (1995). Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Bioessays 17, 395-404.
42. Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D. and Downward, J. (1994). Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532.
43. Rong, R., Ahn, J. Y., Huang, H., Nagata, E., Kalman, D., Kapp, J. A., Tu, J., Worley, P. F., Snyder, S. H. and Ye, K. (2003). PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat. Neurosci. 6, 1153-1161.
44. Scott, C., Keating, L., Bellamy, M. and Baines, A. J. (2001). Protein 4.1 in forebrain postsynaptic density preparations: enrichment of 4.1 gene products and detection of 4.1R binding proteins. Eur. J. Biochem. 268, 1084-1094.
45. Shen, L., Liang, F., Walensky, L. D. and Huganir, R. L. (2000). Regulation of AMPA receptor GluR1 subunit surface expression by a 4.1N-linked actin cytoskeletal association. J. Neurosci. 20, 7932-7940.
46. Smith, M. R., Liu, Y. L., Matthews, N. T., Rhee, S. G., Sung, W. K. and Kung, H. F. (1994). Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity. Proc. Natl. Acad. Sci. USA 91, 6554-6558.
47. Smith, M. R., Ryu, S. H., Suh, P. G., Rhee, S. G. and Kung, H. F. (1989). S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C. Proc. Natl. Acad. Sci. USA 86, 3659-3663.
48. Tanaka, K., Horiguchi, K., Yoshida, T., Takeda, M., Fujisawa, H., Takeuchi, K., Umeda, M., Kato, S., Ihara, S., Nagata, S. et al. (1999). Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus. J. Biol. Chem. 274, 3919-3922.
49. Walensky, L. D., Shi, Z. T., Blackshaw, S., DeVries, A. C., Demas, G. E., Gascard, P., Nelson, R. J., Conboy, J. G., Rubin, E. M., Snyder, S. H. et al. (1998). Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1. Curr. Biol. 8, 1269-1272.
50. Walensky, L. D., Blackshaw, S., Liao, D., Watkins, C. C., Weier, H. U., Parra, M., Huganir, R. L., Conboy, J. G., Mohandas, N. and Snyder, S. H. (1999). A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1. J. Neurosci. 19, 6457-6467.
51. Wang, Z., Gluck, S., Zhang, L. and Moran, M. F. (1998). Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis. Mol. Cell. Biol. 18, 590-597.
52. Xia, C., Ma, W., Stafford, L. J., Liu, C., Gong, L., Martin, J. F. and Liu, M. (2003). GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Mol. Cell. Biol. 23, 2476-2488.
53. Xiao, B., Tu, J. C. and Worley, P. F. (2000). Homer: a link between neural activity and glutamate receptor function. Curr. Opin. Neurobiol. 10, 370-374.
54. Yamada, K. M. and Araki, M. (2001). Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J. Cell Sci. 114, 2375-2382.
55. Ye, K., Compton, D. A., Lai, M. M., Walensky, L. D. and Snyder, S. H. (1999). Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor. J. Neurosci. 19, 10747-10756.
56. Ye, K., Hurt, K. J., Wu, F. Y., Fang, M., Luo, H. R., Hong, J. J., Blackshaw, S., Ferris, C. D. and Snyder, S. H. (2000). Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell 103, 919-930.
57. Ye, K., Aghdasi, B., Luo, H. R., Moriarity, J. L., Wu, F. Y., Hong, J. J., Hurt, K. J., Bae, S. S., Suh, P. G. and Snyder, S. H. (2002). Phospholipase Cgamma1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature 415, 541-544.
58. York, J. D. and Majerus, P. W. (1994). Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells. J. Biol. Chem. 269, 7847-7850.
59. Zini, N., Ognibene, A., Marmiroli, S., Bavelloni, A., Maltarello, M. C., Faenza, I., Valmori, A. and Maraldi, N. M. (1995). The intranuclear amount of phospholipase C beta 1 decreases following cell differentiation in Friend cells, whereas gamma 1 isoform is not affected. Eur. J. Cell Biol. 68, 25-34.