Dendritic Cells and Immunoregulation in the Pathogenesis and Prevention of Type 1 Diabetes

Canadian Journal of Diabetes

Volumn 28, Issue 1, 2004, Pages 20-29

  Summers, Kelly L ^b   Marleau, Annette M ^b   Stephens, Tracey A ^b   Mahon, Jeffrey L ^b   Singh, Bhagirath ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b NONE

Author keywords

Autoimmune disease; Dendritic cells; Ep1.B; Immunoregulation; T cells; Tolerance

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 12;

CELL MATURATION; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 1642354884     PISSN: 14992671     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (71)

1. Wucherpfennig KW, Eisenbarth GS. Type 1 diabetes. Nat Immunol. 2001;2:767-768.
2. Delovitch TL, Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity. 1997;7:727-738.
3. Zipris D, Lazarus AH, Crow AR, et al. Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis. J Immunol. 1991;146:3763-3771.
4. Zhang J, Salojin K, Delovitch TL. Sequestration of CD4-associated Lck from the TCR complex may elicit T cell hyporesponsiveness in nonobese diabetic mice. J Immunol. 1998;160:1148-1157.
5. Lamhamedi-Cherradi S-E, Luan J-J, Eloy L, et al. Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x. Diabetologia. 1998;41:178-184.
6. Garchon HJ, Luan J-J, Eloy L, et al. Genetic analysis of immune dysfunction in non-obese diabetic (NOD) mice: mapping of a susceptibility locus close to the Bcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction. Eur J Immunol. 1994;24:380-384.
7. Leijon K, Hammarstrom B, Holmberg D. Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells. Int Immunol. 1994;6:339-345.
8. Colucci F, Cilio CM, Lejon K, et al. Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide. J Autoimmun. 1996;9:271-276.
9. Colucci F, Bergman M-L, Penha-Gonçalves C, et al. Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the ldd5 diabetes susceptibility region. Proc Natl Acad Sci U S A. 1997;94:8670-8674.
10. lck expression in T lymphocytes from type 1 diabetic patients. J Immunol. 2000;165:5874-5883.
11. Nervi S, Atlan-Gepner C, Fossat C, et al. Constitutive impaired TCR/CD3-mediated activation of T cells in IDDM patients co-exist with normal co-stimulation pathways. J Autoimmun. 1999;13:247-255.
12. Shortman K, Liu Y-J. Mouse and human dendritic cell subtypes. Nat Rev Immunol. 2002;2:151-161.
13. Gluckman J-C, Canque B, Rosenzwajg M. Dendritic cells: a complex simplicity. Transplantation. 2002;73(suppl 1):S3-S6.
14. Guermonprez P, Valladeau J, Zitvogel L, et al. Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol. 2002;20:621-667.
15. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol. 2000;18:767-811.
16. Mahnke K, Schmitt E, Bonifaz L, et al. Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol. 2002;80:477-483.
17. Turley SJ. Dendritic cells: inciting and inhibiting autoimmunity. Curr Opin Immunol. 2002;14:765-770.
18. McLellan AD, Starling GC, Williams LA, et al. Activation of human peripheral blood dendritic cells induces the CD86 co-stimulatory molecule. Eur J Immunol. 1995;25:2064-2068.
19. Coyle AJ, Gutierrez-Ramos J-C. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat Immunol. 2001;2:203-209.
20. Lanier LL, O'Fallon S, Somoza C, et al. CD80 (B7) and CD86 (B70) provide similar costimulatory signals forT cell proliferation, cytokine production, and generation of CTL. J Immunol. 1995;154:97-105.
21. Schweitzer AN, Borriello F, Wong RC, et al. Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86. J Immunol. 1997;158:2713-2722.
22. Freeman GJ, Boussiotis VA, Anumanthan A, et al. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity. 1995;2:523-532.
23. Kuchroo VK, Das MP, Brown JA, et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 1995;80:707-718.
24. Freeman GJ, Borriello F, Hodes RJ, et al. Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. J Exp Med. 1993;178:2185-2192.
25. + regulatory T cells. Eur J Immunol. 2002;32:2888-2896.
26. Lohr J, Knoechel B, Jiang S, et al. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol. 2003;4:664-669.
27. Jansen A, Homo-Delarche F, Hooijkaas H, et al. Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice. Diabetes. 1994;43:667-675.
28. Shinomiya M, Nadano S, Shinomiya H, et al. In situ characterization of dendritic cells occurring in the islets of nonobese diabetic mice during the development of insulitis. Pancreas. 2000;20:290-296.
29. Ziegler AG, Erhard J, Lampeter EF, et al. Involvement of dendritic cells in early insulitis of BB rats. J Autoimmun. 1992;5:571-579.
30. Jansen A, Voorbij HA, Jeucken PH, et al. An immunohistochemical study on organized lymphoid cell infiltrates in fetal and neonatal pancreases. A comparison with similar infiltrates found in the pancreas of a diabetic infant. Autoimmunity. 1993;15:31-38.
31. Summers KL, Behme MT, Mahon JL, et al. Characterization of dendritic cells in humans with type 1 diabetes. Ann N Y Acad Sci. 2003;1005:226-229.
32. Feili-Hariri M, Morel PA. Phenotypic and functional characteristics of BM-derived DC from NOD and non-diabetes-prone strains. Clin Immunol. 2001;98:133-142.
33. Marleau AM, Singh B. Myeloid dendritic cells in non-obese diabetic mice have elevated costimulatory and T helper-1-inducing abilities. J Autoimmun. 2002;19:23-35.
34. Strid J, Lopes L, Marcinkiewicz J, et al. A defect in bone marrow derived dendritic cell maturation in the nonobesediabetic mouse. Clin Exp Immunol. 2001;123:375-381.
35. Takahashi K, Honeyman MC, Harrison LC. Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin-dependent diabetes. J Immunol. 1998;161:2629-2635.
36. Jansen A, van Hagen M, Drexhage HA. Defective maturation and function of antigen-presenting cells in type 1 diabetes. Lancet. 1995;345:491-492.
37. Kitajima T, Caceres-Dittmar G, Tapia FJ, et al. T cell-mediated terminal maturation of dendritic cells: loss of adhesive and phagocytotic capacities. J Immunol. 1996;157:2340-2347.
38. Peng X, Kasran A, Warmerdam PA, et al. Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production. Eur J Immunol. 1996;26:1621-1627.
39. Lu Q, Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science. 2001;293:306-311.
40. Blanco P, Palucka AK, Gill M, et al. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science. 2001;294:1540-1543.
41. Serreze DV, Prochazka M, Reifsnyder PC, et al. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med. 1994;180:1553-1558.
42. Fox CJ, Danska JS. Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation. Diabetes. 1998;47:331-338.
43. Weaver DJ Jr, Poligone B, Bui T, et al. Dendritic cells from nonobese diabetic mice exhibit a defect in NF-κB regulation due to a hyperactive IκB kinase. J Immunol. 2001;167:1461-1468.
44. Poligone B, Weaver DJ Jr, Sen P, et al. Elevated NF-κB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J Immunol. 2002;168:188-196.
45. Morahan G, Huang D, Ymer SI, et al. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory ILI 2B allele. Nat Genet. 2001;27:218-221.
46. Liu J, Beller D. Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-κB expression and binding to the IL-12 p40 promoter. J Immunol. 2002;169:581-586.
47. Stephens TA. Characterization of Monocyte to Dendritic Cell Differentiation Induced by a Self-peptide Derived From Apolipoprotein E [master's thesis]. London, ON: University of Western Ontario; 2002.
48. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622-630.
49. Okano Y, Macy M, Cardin AD, et al. Suppression of lymphocyte activation by plasma lipoproteins: modulation by cell number and type. Exp Cell Biol. 1985;53:199-212.
50. Pepe MG, Curtiss LK. Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein, LDL-In. J Immunol. 1986;136:3716-3723.
51. Kelly ME, Clay MA, Mistry MJ, et al. Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: production of interleukin 2 with reduced biological activity. Cell Immunol. 1994;159:124-139.
52. 1 phase. J Biol Chem. 1998;273:20156-20161.
53. Vogel T, Guo NH, Guy R, et al. Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation. J Cell Biochem. 1994;54:299-308.
54. Ardeshna KM, Pizzey AR, Devereux S, et al. The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood. 2000;96:1039-1046.
55. Puig-Kröger A, Relloso M, Fernández-Capetillo O, et al. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood. 2001; 98:2175-2182.
56. + monocytes through distinct pathways that activate NF-κB. J Immunol. 2000;165:3647-3655.
57. Matsue H, Kusuhara M, Matsue K, et al. Dendritic cell-based immunoregulatory strategies. Int Arch Allergy Immunol. 2002;127:251-258.
58. Shinomiya M, Fazle Akbar SM, Shinomiya H, et al. Transfer of dendritic cells (DC) ex vivo stimulated with interferon-gamma (IFN-γ) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol. 1999;117:38-43.
59. Clare-Salzler MJ, Brooks J, Chai A, et al. Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer. J Clin Invest. 1992;90:741-748.
60. Feili-Hariri M, Dong X, Alber SM, et al. Immunotherapy of NOD mice with bone marrow-derived dendritic cells. Diabetes. 1999;48:2300-2308.
61. Feili-Hariri M, Falkner DH, Morel PA. Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice. Eur J Immunol. 2002;32:2021-2030.
62. Maraskovsky E, Brasel K, Teepe M, et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med. 1996;184:1953-1962.
63. Brasel K, De Smedt T, Smith JL, et al. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood. 2000;96:3029-3039.
64. Maraskovsky E, Daro E, Roux E, et al. In vivo generation of human dendritic cell subsets by Flt3 ligand. Blood. 2000;96:878-884.
65. Hanada K, Tsunoda R, Hamada H. GM-CSF-induced in vivo expansion of splenic dendritic cells and their strong costimulation activity. J Leukoc Biol. 1996;60:181-190.
66. Masurier C, Pioche-Durieu C, Colombo BM, et al. Immunophenotypical and functional heterogeneity of dendritic cells generated from murine bone marrow cultured with different cytokine combinations: implications for anti-tumoral cell therapy. Immunology. 1999;96:569-577.
67. Latchumanan VK, Singh B, Sharma P, et al. Mycobacterium tuberculosis antigens induce the differentiation of dendritic cells from bone marrow. J Immunol. 2002;169:6856-6864.
68. Serreze DV, Hamaguchi K, Leiter EH. Immunostimulation circumvents diabetes in NOD/Lt mice. J Autoimmun. 1989;2:759-776.
69. Pennline KJ, Roque-Gaffney E, Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol. 1994;71:169-175.
70. Debray-Sachs M, Carnaud C, Boitard C, et al. Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma. J Autoimmun. 1991;4:237-248.
71. Nicoletti F, Zaccone P, Di Marco R, et al. The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology. 1996;137:5567-5575.