Bacterial lipopolysaccharide, TNF-α, and calcium ionophore under serum-free conditions promote rapid dendritic cell-like differentiation in CD14+ monocytes through distinct pathways that activate NF-κB

Journal of Immunology

Volumn 165, Issue 7, 2000, Pages 3647-3655

  Lyakh, L A ^a   Koski, G K ^a   Telford, W ^a   Gress, R E ^a   Cohen, P A ^a   Rice, N R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CALCIUM IONOPHORE; CD14 ANTIGEN; CYCLOSPORIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; DENDRITIC CELL; DRUG EFFECT; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

EID: 0034292334     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.7.3647     Document Type: Article

References (46)

1. Antigen capture, processing, and presentation by dendritic cells: Recent cell biological studies
2. Myeloid dendritic-cells
3. Dendritic cells and the control of immunity
4. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1
5. Dendritic cells
6. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor-α
7. + dendritic cells
8. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells
9. Dendritic cells as the terminal stage of monocyte differentiation
10. Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells
11. Calcium mobilization in human myeloid cells results in acquisition of individual dendritic cell-like characteristics through discrete signaling pathways
12. Homologous ELISA for detection of oligomeric human TNF: Properties of the assay
13. Calcium ionophore-treated myeloid cells acquire many dendritic cell characteristics independent of prior differentiation state, transformation status, or sensitivity to biologic agents
14. The precursor of NF-κB p50 has IκB-like functions
15. Expression of NFAT-family proteins in normal human T cells
16. I-Rel: A novel rel-related protein that inhibits NF-κB transcriptional activity
17. Lipopolysaccharide (LPS) stimulates fresh human monocytes to lyse actinomycin D-treated WEHI-164 target cells via increased secretion of a monokine similar to tumor necrosis factor
18. Tumor necrosis factor production by human monocytes is a regulated event: Induction of TNF-α-mediated cellular cytotoxicity by endotoxin
19. Coexpression of NF-κB/Rel and Sp1 transcription factors in human immunodeficiency virus 1-induced dendritic cell-T-cell syncytia
20. Nuclear localization of RelB is associated with effective antigen-presenting cell function
21. + dendritic cells
22. An analysis of the 5′-noncoding sequences from 699 vertebrate messenger RNA's
23. 2+, calcineurin, and NF-AT
24. Transcription factors of the NFAT family: Regulation and function
25. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
26. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo
27. SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes
28. Differential regulation of lipopolysaccharide (LPS) activation pathways in mouse macrophages by LPS-binding proteins
29. Characterization of tumor necrosis factor-deficient mice
30. Differential expression of the transcription factor NF-κB during human mononuclear phagocyte differentiation to macrophages and dendritic cells
31. Dendritic cell survival and maturation are regulated by different signaling pathways
32. N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: Association with NF-κB inhibition
33. Tlr4: Central component of the sole mammalian LPS sensor
34. NF-κB and the innate immune response
35. 2+ and reactive oxygen intermediates as messengers
36. Activation of NF-κB in normal rat kidney epithelial (NRK52E) cells is mediated via a redox-insensitive, calcium-dependent pathway
37. 2+ and protein kinase C as messengers
38. Activators and target genes of Rel/NF-κB transcription factors
39. T suppressor lymphocytes inhibit NF-κB-mediated transcription of CD86 gene in APC
40. Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes
41. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
42. NF-κB-mediated up-regulation of Bcl-x and Bfl-1/Al is required for CD40 survival signaling in B lymphocytes
43. Multifocal defects in immune responses in RelB-deficient mice
44. Expression of relB is required for the development of thymic medulla and dendritic cells
45. + hemopoietic progenitors to dendritic cells: Evidence for protein kinase C-mediated signaling
46. IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production