Promoter hypermethylation of MGMT, CDHI, RAR-β and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin

British Journal of Cancer

Volumn 90, Issue 4, 2004, Pages 874-881

  Dhillon, V S ^a,c   Young, A R ^a   Husain, S A ^b   Aslam, M ^b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^c CSIRO   (Australia)

Author keywords

CDHI; Hypermethylation of MGMT; Ovarian carcinoma; RAR and SYK gene

Indexed keywords

HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN KINASE SYK; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA; UVOMORULIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA RESPONSIVE ELEMENT; EARLY DIAGNOSIS; EPIGENETICS; FEMALE; GENE SILENCING; GRANULOSA CELL TUMOR; HUMAN; HUMAN TISSUE; MONOSOMY; MONOSOMY 22; NUCLEOTIDE SEQUENCE; OVARY CARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; STATISTICAL ANALYSIS; TRISOMY; TRISOMY 14; TUMOR SUPPRESSOR GENE; AMINO ACID SEQUENCE; CELL TRANSFORMATION; GENETICS; MIDDLE AGED; MOLECULAR GENETICS; OVARY TUMOR; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; AMINO ACID SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; DNA METHYLATION; FEMALE; GENES, TUMOR SUPPRESSOR; GRANULOSA CELL TUMOR; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OVARIAN NEOPLASMS; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 1642334155     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601567     Document Type: Article

References (55)

1. Bae SI, Lee HS, Kim SH, Kim WH (2002) Inactivation of 06-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers. Br J Cancer Res 86: 1888-1892
2. Baldwin RL, Nemeth E, Tran H, Shvartsman H, Cass I, Narod S, Karlan BY (2000) BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. Cancer Res 60: 5329-5333
3. Chambon P (1996) A decade of molecular biology of retinoic acid receptors. FASEM J 10: 940-954
4. Chu DH, Morita CT, Weiss A (1998) The Syk family of protein tyrosine kinases in T-cell activation and development. Immunol Rev 165: 167-180
5. Coopman PJ, Do MT, Barth M, Bowden ET, Hayes AJ, Basyuk E, Blancato JK, Vezza PR, McLeskey SW, Mangeat PH, Mueller SC (2000) The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature (London) 406: 742-747
6. Corn PG, Heath EI, Heitmiller R, Fogt F, Forastiere AA, Herman JG, Wu TT (2001) Frequent hypermethylation of the 5′ CpG island of E-Cadherin in esophageal adenocarcinoma. Clin Cancer Res 7: 2765-2769
7. Dal Cin P, Qi H, Pauwels P, Backx C, Van den Berghe H (1997) Monosomy 22 in a fibrothecoma. Cancer Genet Cytogenet 99: 129-131
8. de The H, Vivanco-Ruiz MM, Tiollais P, Stunnenberg H, Dejean A (1990) Identification of a retinoic acid response element in the retinoic acid receptor b gene. Nature (London) 343: 177-180
9. Duesberg P, Li R, Rasmick D, Rausch C, Willer A, Kraemer A, Yerganian G, Hehlman R (2000) Aneuploidy precedes and segregates with chemical carcinogenesis. Cancer Genet Cytogenet 119: 83-93
10. Eden A, Gandet F, Waghmare A, Jaenisch R (2003) Chromosomal instability and tumour promoted by DNA hypomethylation. Science 300: 455
11. Esteller M, Catasus L, Matias-Guiu X, Mutter GL, Prat J, Baylin SB, Herman JG (1999a) hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis. Am J Pathol 155: 1767-1772
12. Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG (1999b) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59: 793-797
13. 6-Methylguanine-DNA Methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 60: 2368-2371
14. Evan MF, McDicken IW, Herrington CS (1999) Numerical abnormalities of chromosomes 1, 11, 17, and X are associated with stromal invasion in serous and mucinous epithelial ovarian tumours. J Pathol 189: 53-59
15. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ (1999) Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 59: 1090-1095
16. Gandet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H, Jaenisch R (2003) Induction of tumours in mice by genomic hypomethylation. Science 300: 489-492
17. Garcia del Muro X, Torregrosa A, Munoz J, Castellsague X, Condom E, Vigues F, Arance A, Fabra A, Germa JR (2000) Prognostic value of the expression of E-cadherin and β-catenin in bladder cancer. Eur J Cancer 36: 357-362
18. Gebert JF, Moghal N, Frangioni JV, Sugerbaker DJ, Neel BG (1991) High frequency of retinoic acid receptor β abnormalities in human lung cancer. Oncogene 6: 1859-1868
19. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB (1995) E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 55: 5195-5199
20. Gras E, Catasus L, Arguelles R, Moreno-Bueno G, Palacios J, Gamallo C, Matias-Guiu X, Prat J (2001) Microsatellite instability, MLH-1 promoter hypermethylation, and frame shift mutations at coding mononucleotide repeat microsatellites in ovarian tumours. Cancer 92: 2829-2836
21. Hayashi K, Yokozaki H, Naka K, Yasui W, Lotan R, Tahara E (2001) Overexpression of retinoic acid receptor induces growth arrest and apoptosis in oral cancer cell lines. Jpn J Cancer Res 92: 42-50
22. Heimann R, Lan F, McBride R, Hellman S (2000) Separating favourable from unfavourable prognostic markers in breast cancer: the role of E-cadherin. Cancer Res 60: 298-304
23. Herman JG, Jen J, Merlo A, Baylin SB (1996) Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 56: 722-727
24. Herman JG, Latif F, Weng Y, Lerman LI, Zbar B, Lin S, Samid D, Duan DS, Gnarra JR, Linechan WM (1994) Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91: 9700-9704
25. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA, Baylin SB (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 95: 6870-6875
26. Jimi S, Shono T, Tanaka M, Kono A, Yamada Y, Sudo K, Kuwano M (1998) Effect of retinoic acid on morphological changes of human pancreatic cancer cells on collagen gels: a possible association with the metastatic potentials. Oncol Res 10: 7-14
27. Leung SY, Yuen ST, Chung LP, Chu KM, Chan AS, Ho JC (1999) hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 59: 159-164
28. Lotan R (1980) Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 605: 33-91
29. Lotan R (1995) Retinoids and apoptosis: implications for cancer chemoprevention and therapy. J Natl Cancer Inst 87: 1655-1657
30. Lotan R, Xu C, Lippman SM, Ro JY, Lee JS, Lee JJ, Hong WK (1995) Suppression of retinoic acid receptor β in premalignant oral lesions and its up-regulation by isotretinoin. N Engl J Med 332: 1405-1410
31. Maruyama R, Toyooka S, Toyooka KO, Harada K, Virmani AK, Zochbauer-Muller S, Farinas AJ, Vakar-Lopez F, Minna JD, Sagalowsky A, Czerniak B, Gazdar AF (2001) Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. Cancer Res 61: 8659-8663
32. Maruyama R, Toyooka S, Toyooka KO, Virmani AK, Zochbauer-Muller S, Farinas AJ, Minna JD, McConnell J, Frenkel EP, Gazdar AF (2002) Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features. Clin Cancer Res 8: 514-519
33. Merlo A, Herman JG, Mao L, Lee DJ, Gabreilson E, Burger PC, Baylin SB, Sidransky D (1995) 5′-CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers [see comments]. Nat Med 1: 686-692
34. Nakayama K, Takebayashi Y, Namiki T, Tamahashi N, Nakayama S, Uchida T, Miyazaki K, Fukumoto M (2001) Comprehensive allelotype study of ovarian tumours of low malignant potential: potential differences in pathways between tumours with and without genetic predisposition to invasive carcinoma. Int J Cancer 94: 605-609
35. INK4a, CDH1 and RAR-beta in intestinal, diffuse-adherant, and diffuse-scattered type gastric carcinomas. J Pathol 198: 55-59
36. Rosas SL, Koch W, da Costa Carvalho MG, Wu L, Califano J, Westra W, Jen J, Sidransky G (2001) Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res 61: 939-942
37. Russel P, Bannatyne P (1989) Surgical Pathology of Ovaries. London: Churchill Livingstone
38. Sadot E, Simcha I, Shtutman M, Ben-Ze'ev A, Geiger B (1998) Inhibition of β-catenin-mediated transactivation by cadherin derivatives. Proc Natl Acad Sci USA 95: 15339-15344
39. Sandberg AA (1991) Chromosome abnormalities in human cancer and leukaemia. Mutat Res 247: 231-240
40. Seewaldt VL, Johnson BS, Parker MB, Collins SJ, Swisshelm K (1995) Expression of retinoic acid receptor-b mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells. Cell Growth Differ 6: 1077-1088
41. Speleman F, Dermaut B, De Potter CR, Van Gele M, Van Roy N, De Paepe A, Laureys G (1997) Monosomy 22 in a mixed germ cell-sex cord-stromal tumor of the ovary. Genes Chromosomes Cancer 19: 192-194
42. Stein R, Gruenbaum Y, Pollack Y, Rajin A, Cedar H (1982) Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci USA 79: 61-65
43. Suzuki M, Ohwada M, Saga Y, Ochiai K, Sato I (2000) DNA replication error is frequent in ovarian granulosa cell tumors. Cancer Genet Cytogenet 122: 55-58
44. Takeichi M (1995) Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 7: 619-627
45. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ (2000) E-cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst (Bethesda) 92: 569-573
46. Van den Berghe I, Dal Cin P, De Groef K, Michielssen P, Van den Berghe H (1999) Monosomy 22 and trisomy 14 may be early events in the tumorigenesis of adult granulosa cell tumor. Cancer Genet Cytogenet 112: 46-48
47. Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF (2000) Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas. J Natl Cancer Inst 92: 1303-1307
48. Wade PA, Gegonne A, Jones PL, Ballester E, Aubry F, Wolffe AP (1999) Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet 23: 62-66
49. Xu X-C, Ro JY, Lee JS, Shin DM, Hong YK, Lotan R (1994) Differential expression of nuclear retinoid receptors receptors in normal, premalignant and malignant head and neck tissues. Cancer Res 54: 3580-3587
50. Xu X-C, Sneige N, Liu X, Nandagiri R, Lee JJ, Lukmanji F, Hortobagyi G, Lippman SM, Dhingra K, Lotan R (1997) Progressive decrease in nuclear retinoic acid receptor b messenger RNA levels during breast carcinogenesis. Cancer Res 57: 4992-4996
51. Yang Q, Mori I, Shan L, Nakamura M, Nakamura Y, Utsunomiya H, Yoshimura G, Suzuma T, Tamaki T, Umemura T, Sakurai T, Kakudo K (2001) Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer. Am J Pathol 158: 299-303
52. Yoon JH, Dammann R, Pfeifer GP (2001) Hypermethylation of the CpG islands of the RASSF1A gene in ovarian and renal cell carcinomas. Int J Cancer 94: 212-217
53. Yoshiura K, Kanai Y, Ochiai A, Shimoyama Y, Sugimura T, Hirohashi S (1995) Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci USA 92: 7416-7419
54. Yuan Y, Mendez R, Sahin A, Dai JL (2001) Hypermethylation leads to silencing of the SYK gene in human breast cancer. Cancer Res 61: 5558-5561
55. Zheng Z, Pan J, Chu B, wong YC, Cheung AL, Tsao SW (1999) Downregulation and abnormal expression of E-cadherin and β-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis. Hum Pathol 30: 458-466