Cisplatin-induced apoptosis in Hep3B cells: Mitochondria-dependent and -independent pathways

Biochemical Pharmacology

Volumn 67, Issue 8, 2004, Pages 1459-1468

  Kim, Ji Su ^a   Lee, Jae Myun ^a   Chwae, Yong Joon ^b   Kim, Yeon Hyang ^a   Lee, Jung Hwan ^a   Kim, Kunhong ^c   Lee, Tae Ho ^d   Kim, Se Jong ^a   Park, Jeon Han ^a  

^a Institute for Immunology and Immunological Diseases   (South Korea)

^b CHA University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

^d Yonsei University   (South Korea)

Author keywords

m; Cisplatin; CP; Mitochondrial membrane potential; Permeability transition; PI; Propidium iodide; PT; Second mitochondria derived activator of caspase; Smac; z VAD fmk

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CISPLATIN; CYTOCHROME C; FAS ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROTEIN; PROTEIN BAX; PROTEIN P53; PROTEIN P73; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; ASSOCIATION; CANCER CELL CULTURE; CELL STRAIN; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; DRUG MECHANISM; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RIBONUCLEASE PROTECTION ASSAY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CASPASES; CISPLATIN; CYTOCHROMES C; DNA-BINDING PROTEINS; DOWN-REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NF-KAPPA B; NUCLEAR PROTEINS; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 1642326520     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.12.013     Document Type: Article

References (31)

1. Lee R.H., Song J.M., Park M.Y., Kang S.K., Kim Y.K., Jung J.S. Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells. Biochem. Pharmacol. 62:2001;1013-1023.
2. Park M.S., De Leon M., Devarajan P. Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways. J. Am. Soc. Nephrol. 13:2002;858-865.
3. Jiang S., Cai J., Wallace D.C., Jones D.P. Cytochrome c-mediated apoptosis in cells lacking mitochondrial DNA. Signaling pathway involving release and caspase 3 activation is conserved. J. Biol. Chem. 274:1999;29905-29911.
4. Bortner C.D., Cidlowski J.A. Cellular mechanisms for the repression of apoptosis. Annu. Rev. Pharmacol. Toxicol. 42:2002;259-281.
5. Gao C.F., Ren S., Zhang L., Nakajima T., Ichinose S., Hara T., Koike K., Tsuchida N. Caspase-dependent cytosolic release of cytochrome c and membrane translocation of Bax in p53-induced apoptosis. Exp. Cell Res. 265:2001;145-151.
6. Rosse T., Olivier R., Monney L., Rager M., Conus S., Fellay I., Jansen B., Borner C. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature. 391:1998;496-499.
7. Deveraux Q.L., Roy N., Stennicke H.R., Van Arsdale T., Zhou Q., Srinivasula S.M., Alnemri E.S., Salvesen G.S., Reed J.C. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 17:1998;2215-2223.
8. Du C., Fang M., Li Y., Li L., Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102:2000;33-42.
9. Verhagen A.M., Ekert P.G., Pakusch M., Silke J., Connolly L.M., Reid G.E., Moritz R.L., Simpson R.J., Vaux D.L. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 102:2000;43-53.
10. Plumpe J., Malek N.P., Bock C.T., Rakemann T., Manns M.P., Trautwein C. NF-kappaB determines between apoptosis and proliferation in hepatocytes during liver regeneration. Am. J. Physiol. Gastrointest Liver Physiol. 278:2000;G173-G183.
11. Wang C.Y., Cusack J.C. Jr., Liu R., Baldwin A.S. Jr. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat. Med. 5:1999;412-417.
12. Wang C.Y., Mayo M.W., Korneluk R.G., Goeddel D.V., Baldwin A.S. Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 281:1998;1680-1683.
13. Tang G., Minemoto Y., Dibling B., Purcell N.H., Li Z., Karin M., Lin A. Inhibition of JNK activation through NF-kappaB target genes. Nature. 414:2001;313-317.
14. Levrero M., De Laurenzi V., Costanzo A., Gong J., Wang J.Y., Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J. Cell Sci. 113(Pt 10):2000;1661-1670.
15. Zhu J., Jiang J., Zhou W., Chen X. The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res. 58:1998;5061-5065.
16. Jiang S., Song M.J., Shin E.C., Lee M.O., Kim S.J., Park J.H. Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways. Hepatology. 29:1999;101-110.
17. Hsu H., Xiong J., Goeddel D.V. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell. 81:1995;495-504.
18. Chwae Y.J., Chang M.J., Park S.M., Yoon H., Park H.J., Kim S.J., Kim J. Molecular mechanism of the activation-induced cell death inhibition mediated by a p70 inhibitory killer cell Ig-like receptor in Jurkat T cells. J. Immunol. 169:2002;3726-3735.
19. Narita M., Shimizu S., Ito T., Chittenden T., Lutz R.J., Matsuda H., Tsujimoto Y. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. USA. 95:1998;14681-14686.
20. Sanchez-Alcazar J.A., Khodjakov A., Schneider E. Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death. Cancer Res. 61:2001;1038-1044.
21. Adrain C., Creagh E.M., Martin S.J. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J. 20:2001;6627-6636.
22. Li X., Stark G.R. NFkappaB-dependent signaling pathways. Exp. Hematol. 30:2002;285-296.
23. Maldonado V., Melendez-Zajgla J., Ortega A. Modulation of NF-kappa B, and Bcl-2 in apoptosis induced by cisplatin in HeLa cells. Mutat. Res. 381:1997;67-75.
24. Gong J.G., Costanzo A., Yang H.Q., Melino G., Kaelin W.G. Jr., Levrero M., Wang J.Y. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature. 399:1999;806-809.
25. Blanc C., Deveraux Q.L., Krajewski S., Janicke R.U., Porter A.G., Reed J.C., Jaggi R., Marti A. Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. Cancer Res. 60:2000;4386-4390.
26. Gross A., Jockel J., Wei M.C., Korsmeyer S.J. Enforced dimerization of BAX results in its translocation. EMBO J. 17:1998;3878-3885.
27. Bours V., Bonizzi G., Bentires-Alj M., Bureau F., Piette J., Lekeux P., Merville M. NF-kappaB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment. Toxicology. 153:2000;27-38.
28. Chai J., Du C., Wu J.W., Kyin S., Wang X., Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 406:2000;855-862.
29. Jost C.A., Marin M.C., Kaelin W.G. Jr. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature. 389:1997;191-194.
30. Murakami Y., Sekiya T. Accumulation of genetic alterations and their significance in each primary human cancer and cell line. Mutat. Res. 400:1998;421-437.
31. Ferreira C.G., Span S.W., Peters G.J., Kruyt F.A., Giaccone G. Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res. 60:2000;7133-7141.