메뉴 건너뛰기




Volumn 400, Issue 1-2, 1998, Pages 421-437

Accumulation of genetic alterations and their significance in each primary human cancer and cell line

Author keywords

Glioma; Hepatocellular carcinoma; Non small cell lung cancer; Oncogene; Pancreatic cancer; Tumor suppressor gene

Indexed keywords

ARTICLE; DNA DETERMINATION; GENE MUTATION; GLIOMA; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; ONCOGENE; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0032565571     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00031-1     Document Type: Article
Times cited : (20)

References (101)
  • 1
    • 0030240944 scopus 로고    scopus 로고
    • How cancer arises
    • [1] R.A. Weinberg, How cancer arises, Sci. Am. 275 (1996) 62-70.
    • (1996) Sci. Am. , vol.275 , pp. 62-70
    • Weinberg, R.A.1
  • 2
    • 0023178425 scopus 로고
    • Human cancer and cellular oncogenes
    • [2] S. Nishimura, T. Sekiya, Human cancer and cellular oncogenes, Biochem. J. 243 (1987) 313-327.
    • (1987) Biochem. J. , vol.243 , pp. 313-327
    • Nishimura, S.1    Sekiya, T.2
  • 3
    • 0029270033 scopus 로고
    • The genetic basis of cancer
    • [3] W.K. Cavenee, R.L. White, The genetic basis of cancer, Sci. Am. 272 (1995) 72-79.
    • (1995) Sci. Am. , vol.272 , pp. 72-79
    • Cavenee, W.K.1    White, R.L.2
  • 5
    • 0024595101 scopus 로고
    • Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms
    • [5] M. Orita, H. Iwahana, H. Kanazawa, K. Hayashi, T. Sekiya, Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms, Proc. Natl. Acad. Sci. USA 86 (1989) 2766-8409.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2766-8409
    • Orita, M.1    Iwahana, H.2    Kanazawa, H.3    Hayashi, K.4    Sekiya, T.5
  • 8
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • [8] J.D. Oliner, K.W. Kinzler, P.S. Meltzer, D.L. George, B. Vogelstein, Amplification of a gene encoding a p53-associated protein in human sarcomas, Nature 358 (1992) 80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 11
    • 0022472990 scopus 로고
    • Requirement for c-ras proteins during viral oncogene transformation
    • [11] M.R. Smith, S.J. DeGudicibus, D.W. Stacey, Requirement for c-ras proteins during viral oncogene transformation, Nature 320 (1986) 540-543.
    • (1986) Nature , vol.320 , pp. 540-543
    • Smith, M.R.1    DeGudicibus, S.J.2    Stacey, D.W.3
  • 12
    • 0022396866 scopus 로고
    • Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice
    • [12] M. Fukui, T. Yamamoto, S. Kawai, K. Maruo, K. Toyoshima, Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice, Proc. Natl. Acad. Sci. USA 82 (1985) 5954-5958.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 5954-5958
    • Fukui, M.1    Yamamoto, T.2    Kawai, S.3    Maruo, K.4    Toyoshima, K.5
  • 14
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • [14] T.F. Franke, S.I. Yang, T.O. Chan, K. Datta, A. Kazlauskas, D.K. Morrison, D.R. Kaplan, P.N. Tsichlis, The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase, Cell 81 (1995) 727-736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 15
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • [15] J.Q. Cheng, B. Ruggeri, W.M. Klein, G. Sonoda, D.A. Altomare, D.K. Watson, J.R. Testa, Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA, Proc. Natl. Acad. Sci. USA 93 (1996) 3636-3641.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3    Sonoda, G.4    Altomare, D.A.5    Watson, D.K.6    Testa, J.R.7
  • 17
    • 0039001059 scopus 로고
    • Improved double-stranded DNA sequencing using the linear polymerase chain reaction
    • [17] V. Murray, Improved double-stranded DNA sequencing using the linear polymerase chain reaction, Nucleic Acids Res. 17 (1989) 8889.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 8889
    • Murray, V.1
  • 19
    • 0026512912 scopus 로고
    • PCR amplification of specific alleles (pASA) is a general method for rapidly detecting known single-base changes
    • [19] S.S. Sommer, A.R. Groszbach, C.D. Bottema, PCR amplification of specific alleles (PASA) is a general method for rapidly detecting known single-base changes, Biotechniques 12 (1992) 82-87.
    • (1992) Biotechniques , vol.12 , pp. 82-87
    • Sommer, S.S.1    Groszbach, A.R.2    Bottema, C.D.3
  • 20
    • 0026566560 scopus 로고
    • Allele specific amplification by tetra-primer PCR
    • [20] S. Ye, S. Humphries, F. Green, Allele specific amplification by tetra-primer PCR, Nucleic Acids Res. 20 (1992) 1152.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 1152
    • Ye, S.1    Humphries, S.2    Green, F.3
  • 21
    • 0022353404 scopus 로고
    • Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA dupexes
    • [21] R.M. Myers, Z. Larin, T. Maniatis, Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA dupexes, Science 230 (1985) 1242-1246.
    • (1985) Science , vol.230 , pp. 1242-1246
    • Myers, R.M.1    Larin, Z.2    Maniatis, T.3
  • 22
    • 1642622866 scopus 로고
    • Methods to detect and characterize point mutations in transcribed genes: Amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells
    • [22] E. Winter, F. Yamamoto, C. Almoguera, M.A. Perucho, Methods to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells, Proc. Natl. Acad. Sci. USA 82 (1985) 7575-7579.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 7575-7579
    • Winter, E.1    Yamamoto, F.2    Almoguera, C.3    Perucho, M.A.4
  • 23
    • 0000023099 scopus 로고
    • Attachment of a 40-base-pair G+C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes
    • [23] V.C. Sheffield, D.R. Cox, D.R. Lerman, R.M. Myers, Attachment of a 40-base-pair G+C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes, Proc. Natl. Acad. Sci. USA 86 (1989) 232-236.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 232-236
    • Sheffield, V.C.1    Cox, D.R.2    Lerman, D.R.3    Myers, R.M.4
  • 24
    • 0025167972 scopus 로고
    • Comprehensive detection of single base changes in hman genomic DNA using denaturing gradient gel electrophoresis and a GC clamp
    • [24] E.S. Abrams, S.E. Murdaugh, L.S. Lerman, Comprehensive detection of single base changes in hman genomic DNA using denaturing gradient gel electrophoresis and a GC clamp, Genomics 7 (1990) 463-475.
    • (1990) Genomics , vol.7 , pp. 463-475
    • Abrams, E.S.1    Murdaugh, S.E.2    Lerman, L.S.3
  • 25
    • 0024756969 scopus 로고
    • Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
    • [25] M. Orita, Y. Suzuki, T. Sekiya, K. Hayashi, Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction, Genomics 5 (1989) 874-879.
    • (1989) Genomics , vol.5 , pp. 874-879
    • Orita, M.1    Suzuki, Y.2    Sekiya, T.3    Hayashi, K.4
  • 26
    • 0025293818 scopus 로고
    • Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products
    • [26] Y. Suzuki, M. Orita, M. Shiraishi, K. Hayashi, T. Sekiya, Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products, Oncogene 5 (1990) 1037-1043.
    • (1990) Oncogene , vol.5 , pp. 1037-1043
    • Suzuki, Y.1    Orita, M.2    Shiraishi, M.3    Hayashi, K.4    Sekiya, T.5
  • 27
    • 0026673041 scopus 로고
    • Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung
    • [27] Y. Kishimoto, Y. Murakami, M. Shiraishi, K. Hayashi, T. Sekiya, Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung, Cancer Res. 52 (1992) 4799-4804.
    • (1992) Cancer Res. , vol.52 , pp. 4799-4804
    • Kishimoto, Y.1    Murakami, Y.2    Shiraishi, M.3    Hayashi, K.4    Sekiya, T.5
  • 28
    • 0028084453 scopus 로고
    • DNA aberrations at the retinoblastoma gene locus in human squamous cell carcinomas of the lung
    • [28] R. Sachse, Y. Murakami, M. Shiraishi, K. Hayashi, T. Sekiya, DNA aberrations at the retinoblastoma gene locus in human squamous cell carcinomas of the lung, Oncogene 9 (1994) 39-47.
    • (1994) Oncogene , vol.9 , pp. 39-47
    • Sachse, R.1    Murakami, Y.2    Shiraishi, M.3    Hayashi, K.4    Sekiya, T.5
  • 30
    • 0022622668 scopus 로고
    • Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene
    • [30] D.M. Valenzuela, J. Groffen, Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene, Nucleic Acids Res. 14 (1986) 843-852.
    • (1986) Nucleic Acids Res. , vol.14 , pp. 843-852
    • Valenzuela, D.M.1    Groffen, J.2
  • 34
    • 0025785811 scopus 로고
    • Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines
    • [34] T. Mitsudomi, J. Viallet, J.L. Mulshine, R.I. Linnoila, J.D. Minna, A.F. Gazdar, Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines, Oncogene 6 (1991) 1353-1362.
    • (1991) Oncogene , vol.6 , pp. 1353-1362
    • Mitsudomi, T.1    Viallet, J.2    Mulshine, J.L.3    Linnoila, R.I.4    Minna, J.D.5    Gazdar, A.F.6
  • 38
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • [38] T. Nobori, K. Miura, D.J. Wu, A. Lois, K. Takabayashi, D.A. Carson, Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers, Nature 368 (1994) 753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 39
    • 0027203117 scopus 로고
    • Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences
    • [39] J.Y. Chen, W.D. Funk, W.E. Wright, J.W. Shay, J.D. Minna, Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences, Oncogene 8 (1993) 2159-2166.
    • (1993) Oncogene , vol.8 , pp. 2159-2166
    • Chen, J.Y.1    Funk, W.D.2    Wright, W.E.3    Shay, J.W.4    Minna, J.D.5
  • 40
    • 0029996282 scopus 로고    scopus 로고
    • Deletions and insertions in the p53 tumor suppressor gene in human cancers: Confirmation of the DNA polymerase slippage/misalignment model
    • [40] M.S. Greenblatt, A.P. Grollman, C.C. Harri, Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model, Cancer Res. 56 (1996) 2130-2136.
    • (1996) Cancer Res. , vol.56 , pp. 2130-2136
    • Greenblatt, M.S.1    Grollman, A.P.2    Harri, C.C.3
  • 43
    • 0020683694 scopus 로고
    • Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue
    • [43] D.J. Capon, E.Y. Chen, A.D. Levinson, P.H. Seeburg, D.V. Goeddel, Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue, Nature 302 (1983) 33-37.
    • (1983) Nature , vol.302 , pp. 33-37
    • Capon, D.J.1    Chen, E.Y.2    Levinson, A.D.3    Seeburg, P.H.4    Goeddel, D.V.5
  • 45
    • 0028978675 scopus 로고
    • p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines
    • [45] M. Ramet, K. Castren, K. Jarvinen, K. Pekkala, T. Turpeenniemi-Hujanen, p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines, Carcinogenesis 16 (9) (1995) 2117-2124.
    • (1995) Carcinogenesis , vol.16 , Issue.9 , pp. 2117-2124
    • Ramet, M.1    Castren, K.2    Jarvinen, K.3    Pekkala, K.4    Turpeenniemi-Hujanen, T.5
  • 46
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • [46] A.J. Levine, J. Momand, C.A. Finlay, The p53 tumour suppressor gene, Nature 351 (1991) 453-456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 47
    • 0021699564 scopus 로고
    • A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer
    • [47] Y. Taya, K. Hosogai, S. Hirohashi, Y. Shimosato, R. Tsuchiya, N. Tsuchida, M. Fushimi, T. Sekiya, S. Nishimura, A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer, EMBO J. 3 (1984) 2943-2946.
    • (1984) EMBO J. , vol.3 , pp. 2943-2946
    • Taya, Y.1    Hosogai, K.2    Hirohashi, S.3    Shimosato, Y.4    Tsuchiya, R.5    Tsuchida, N.6    Fushimi, M.7    Sekiya, T.8    Nishimura, S.9
  • 48
    • 0025935611 scopus 로고
    • Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis
    • [48] Y. Murakami, K. Hayashi, T. Sekiya, Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis, Cancer Res. 51 (1991) 3356-3361.
    • (1991) Cancer Res. , vol.51 , pp. 3356-3361
    • Murakami, Y.1    Hayashi, K.2    Sekiya, T.3
  • 49
    • 0026057176 scopus 로고
    • Inactivation of the retinoblastoma gene in a human lung carcinoma cell line detected by single-strand conformation polymorphism analysis of the polymerase chain reaction product of cDNA
    • [49] Y. Murakami, M. Katahira, R. Makino, K. Hayashi, S. Hirohashi, T. Sekiya, Inactivation of the retinoblastoma gene in a human lung carcinoma cell line detected by single-strand conformation polymorphism analysis of the polymerase chain reaction product of cDNA, Oncogene 6 (1991) 37-42.
    • (1991) Oncogene , vol.6 , pp. 37-42
    • Murakami, Y.1    Katahira, M.2    Makino, R.3    Hayashi, K.4    Hirohashi, S.5    Sekiya, T.6
  • 51
    • 0030568077 scopus 로고    scopus 로고
    • Inhibition of lung tumor cell growth in vitro and mouse lung tumor formation by lovastatin
    • [51] M.A. Hawk, K.T. Cesen, J.C. Siglin, G.D. Stoner, R.J. Ruch, Inhibition of lung tumor cell growth in vitro and mouse lung tumor formation by lovastatin, Cancer Lett. 109 (1996) 217-222.
    • (1996) Cancer Lett. , vol.109 , pp. 217-222
    • Hawk, M.A.1    Cesen, K.T.2    Siglin, J.C.3    Stoner, G.D.4    Ruch, R.J.5
  • 52
    • 0000581811 scopus 로고    scopus 로고
    • Genetic alterations in human pancreatic cancer
    • [52] Y. Murakami, Genetic alterations in human pancreatic cancer, J. Hepatol. Bil. Pancr. Surg. 4 (1997) 283-290.
    • (1997) J. Hepatol. Bil. Pancr. Surg. , vol.4 , pp. 283-290
    • Murakami, Y.1
  • 54
    • 0028033602 scopus 로고
    • Mutations of the adenomatous polyposis coli gene in the mutation cluster region: Comparison of human pancreatic and colorectal cancers
    • [54] K. Yashima, S. Nakamori, Y. Murakami, A. Yamaguchi, K. Hayashi, O. Ishikawa, Y. Konishi, T. Sekiya, Mutations of the adenomatous polyposis coli gene in the mutation cluster region: comparison of human pancreatic and colorectal cancers, Int. J. Cancer 59 (1994) 43-47.
    • (1994) Int. J. Cancer , vol.59 , pp. 43-47
    • Yashima, K.1    Nakamori, S.2    Murakami, Y.3    Yamaguchi, A.4    Hayashi, K.5    Ishikawa, O.6    Konishi, Y.7    Sekiya, T.8
  • 56
    • 0028109165 scopus 로고
    • Comparative analysis of mutations in the p53 and k-ras genes in pancreatic cancer
    • [56] G. Berrozpe, J. Schaeffer, M.A. Peinado, F.X. Real, M. Perucho, Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer, Int. J. Cancer 58 (1994) 185-191.
    • (1994) Int. J. Cancer , vol.58 , pp. 185-191
    • Berrozpe, G.1    Schaeffer, J.2    Peinado, M.A.3    Real, F.X.4    Perucho, M.5
  • 57
    • 0029880379 scopus 로고    scopus 로고
    • Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors
    • [57] M. Naumann, N. Savitskaia, C. Eilert, A. Schramm, H. Kalthoff, W. Schmiegel, Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors, Gastroenterology 110 (1996) 1215-1224.
    • (1996) Gastroenterology , vol.110 , pp. 1215-1224
    • Naumann, M.1    Savitskaia, N.2    Eilert, C.3    Schramm, A.4    Kalthoff, H.5    Schmiegel, W.6
  • 59
    • 0030043385 scopus 로고    scopus 로고
    • Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas
    • [59] L. Huang, T.L. Goodrow, S.Y. Zhang, A.J. Klein-Szanto, H. Chang, B.A. Ruggeri, Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas, Cancer Res. 56 (1996) 1137-1141.
    • (1996) Cancer Res. , vol.56 , pp. 1137-1141
    • Huang, L.1    Goodrow, T.L.2    Zhang, S.Y.3    Klein-Szanto, A.J.4    Chang, H.5    Ruggeri, B.A.6
  • 61
    • 0026663706 scopus 로고
    • Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes
    • [61] B. Ruggeri, S.Y. Zhang, J. Caamano, M. DiRado, S.D. Flynn, A.J. Klein-Szanto, Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes, Oncogene 7 (1992) 1503-1511.
    • (1992) Oncogene , vol.7 , pp. 1503-1511
    • Ruggeri, B.1    Zhang, S.Y.2    Caamano, J.3    DiRado, M.4    Flynn, S.D.5    Klein-Szanto, A.J.6
  • 63
    • 0028798818 scopus 로고
    • MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines
    • [63] Q. Liu, Y.X. Yan, M. McClure, H. Nakagawa, F. Fujimura, A.K. Rustgi, MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines, Oncogene 10 (1995) 619-622.
    • (1995) Oncogene , vol.10 , pp. 619-622
    • Liu, Q.1    Yan, Y.X.2    McClure, M.3    Nakagawa, H.4    Fujimura, F.5    Rustgi, A.K.6
  • 65
    • 0022977287 scopus 로고
    • Establishment of a human pancreatic adenocarcinoma cell line (PSN-1) with amplifications of both c-myc and activated c-Ki-ras by a point mutation
    • [65] H. Yamada, T. Yoshida, H. Sakamoto, M. Terada, T. Sugimura, Establishment of a human pancreatic adenocarcinoma cell line (PSN-1) with amplifications of both c-myc and activated c-Ki-ras by a point mutation, Biochem. Biophys. Res. Commun. 140 (1986) 167-173.
    • (1986) Biochem. Biophys. Res. Commun. , vol.140 , pp. 167-173
    • Yamada, H.1    Yoshida, T.2    Sakamoto, H.3    Terada, M.4    Sugimura, T.5
  • 66
    • 0026041836 scopus 로고
    • Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas
    • [66] Y. Murakami, K. Hayashi, S. Hirohashi, T. Sekiya, Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas, Cancer Res. 51 (1991) 5520-5525.
    • (1991) Cancer Res. , vol.51 , pp. 5520-5525
    • Murakami, Y.1    Hayashi, K.2    Hirohashi, S.3    Sekiya, T.4
  • 67
    • 0028023861 scopus 로고
    • Deletions of chromosome 13q, mutations in retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma
    • [67] X. Zhang, H.J. Xu, Y. Murakami, R. Sachse, K. Yashima, S. Hirohashi, S.X. Hu, W.F. Benedict, T. Sekiya, Deletions of chromosome 13q, mutations in retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma, Cancer Res. 54 (1994) 4177-4182.
    • (1994) Cancer Res. , vol.54 , pp. 4177-4182
    • Zhang, X.1    Xu, H.J.2    Murakami, Y.3    Sachse, R.4    Yashima, K.5    Hirohashi, S.6    Hu, S.X.7    Benedict, W.F.8    Sekiya, T.9
  • 68
    • 0025318985 scopus 로고
    • Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: Additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis
    • [68] C.A. Richards, S.A. Short, S.S. Thorgeirsson, B.E. Huber BE, Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis, Cancer Res. 50 (1990) 1521-1527.
    • (1990) Cancer Res. , vol.50 , pp. 1521-1527
    • Richards, C.A.1    Short, S.A.2    Thorgeirsson, S.S.3    Huber BE, B.E.4
  • 69
    • 0027207612 scopus 로고
    • p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines
    • [69] I.C. Hsu, T. Tokiwa, W. Bennett, R.A. Metcalf, J.A. Welsh, T. Sun, C.C. Harris, p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines, Carcinogenesis 14 (1993) 987-992.
    • (1993) Carcinogenesis , vol.14 , pp. 987-992
    • Hsu, I.C.1    Tokiwa, T.2    Bennett, W.3    Metcalf, R.A.4    Welsh, J.A.5    Sun, T.6    Harris, C.C.7
  • 72
    • 0010257663 scopus 로고
    • Detection of aberrations of the p53 gene but not the RB gene in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products
    • [72] M. Katahira, Y. Murakami, K. Hayashi, T. Sekiya, Detection of aberrations of the p53 gene but not the RB gene in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products, J. Tokyo Women Med. College 62 (1992) 206-213.
    • (1992) J. Tokyo Women Med. College , vol.62 , pp. 206-213
    • Katahira, M.1    Murakami, Y.2    Hayashi, K.3    Sekiya, T.4
  • 77
    • 0030869505 scopus 로고    scopus 로고
    • p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells
    • [77] T. Ohtsubo, X. Wang, A. Takahashi, K. Ohnishi, H. Saito, C.W. Song, T. Ohnishi, p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells, Cancer Res. 57 (1997) 3910-3913.
    • (1997) Cancer Res. , vol.57 , pp. 3910-3913
    • Ohtsubo, T.1    Wang, X.2    Takahashi, A.3    Ohnishi, K.4    Saito, H.5    Song, C.W.6    Ohnishi, T.7
  • 78
    • 0030033729 scopus 로고    scopus 로고
    • Adenovirus-mediated p16 / CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells
    • [78] J. Fueyo, C. Gomez-Manzano, W.K. Yung, G.L. Clayman, T.J. Liu, J. Bruner, V.A. Levin, A.P. Kyritsis, Adenovirus-mediated p16 / CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells, Oncogene 12 (1996) 103-110.
    • (1996) Oncogene , vol.12 , pp. 103-110
    • Fueyo, J.1    Gomez-Manzano, C.2    Yung, W.K.3    Clayman, G.L.4    Liu, T.J.5    Bruner, J.6    Levin, V.A.7    Kyritsis, A.P.8
  • 79
    • 0026935269 scopus 로고
    • Detection of DNA aberrations in human cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products
    • [79] Y. Murakami, Y. Suzuki, Y. Kishimoto, S. Hirohashi, K. Hayashi, T. Sekiya, Detection of DNA aberrations in human cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products, Tohoku J. Exp. Med. 168 (1992) 247-255.
    • (1992) Tohoku J. Exp. Med. , vol.168 , pp. 247-255
    • Murakami, Y.1    Suzuki, Y.2    Kishimoto, Y.3    Hirohashi, S.4    Hayashi, K.5    Sekiya, T.6
  • 80
    • 0027198877 scopus 로고
    • Detection of mutant sequences by single-strand conformation polymorphism analysis
    • [80] T. Sekiya, Detection of mutant sequences by single-strand conformation polymorphism analysis, Mutat. Res. 288 (1993) 79-83.
    • (1993) Mutat. Res. , vol.288 , pp. 79-83
    • Sekiya, T.1
  • 81
    • 0028520213 scopus 로고
    • Absence of activating mutations of the RAF1 protooncogene in human lung cancer
    • [81] W. Miwa, J. Yasuda, K. Yashima, R. Makino, T. Sekiya, Absence of activating mutations of the RAF1 protooncogene in human lung cancer, Biol. Chem. Hoppe-Seyler 375 (1994) 705-709.
    • (1994) Biol. Chem. Hoppe-Seyler , vol.375 , pp. 705-709
    • Miwa, W.1    Yasuda, J.2    Yashima, K.3    Makino, R.4    Sekiya, T.5
  • 82
    • 0028879664 scopus 로고
    • Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers
    • [82] T. Shimizu, T. Sekiya, Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers, Int. J. Cancer 63 (1995) 616-620.
    • (1995) Int. J. Cancer , vol.63 , pp. 616-620
    • Shimizu, T.1    Sekiya, T.2
  • 83
    • 0027093471 scopus 로고
    • Absence of activating mutations in the transmembrane domain of the c-erbB-2 protooncogene in human lung cancer
    • [83] R. Sachse, Y. Murakami, M. Shiraishi, K. Hayashi, T. Sekiya, Absence of activating mutations in the transmembrane domain of the c-erbB-2 protooncogene in human lung cancer, Jpn. J. Cancer Res. 83 (1992) 1299-1303.
    • (1992) Jpn. J. Cancer Res. , vol.83 , pp. 1299-1303
    • Sachse, R.1    Murakami, Y.2    Shiraishi, M.3    Hayashi, K.4    Sekiya, T.5
  • 85
    • 0002614269 scopus 로고
    • Detection of DNA aberrations in human cancers by single-strand conformation polymorphism analysis of the polymerase chain reaction
    • [85] T. Sekiya, Y. Murakami, K. Hayashi, Detection of DNA aberrations in human cancers by single-strand conformation polymorphism analysis of the polymerase chain reaction, Int. J. Pancreatol. 13 (1993) 69-78.
    • (1993) Int. J. Pancreatol. , vol.13 , pp. 69-78
    • Sekiya, T.1    Murakami, Y.2    Hayashi, K.3
  • 86
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • [86] C. Almoguera, D. Shibata, K. Forrester, J. Martin, N. Arnheim, M. Perucho, Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes, Cell 53 (1988) 549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5    Perucho, M.6
  • 89
    • 0026576723 scopus 로고
    • Hepatocellular carcinoma: Recent progress
    • [89] K. Okada, Hepatocellular carcinoma: recent progress, Hepatology 15 (1992) 948-963.
    • (1992) Hepatology , vol.15 , pp. 948-963
    • Okada, K.1
  • 90
    • 0027430295 scopus 로고
    • Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma
    • [90] Y-J. Zhang, W. Jiang, C.J. Chen, Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma, Biochem. Biophys. Res. Commun. 196 (1993) 1010-1016.
    • (1993) Biochem. Biophys. Res. Commun. , vol.196 , pp. 1010-1016
    • Zhang, Y.-J.1    Jiang, W.2    Chen, C.J.3
  • 91
    • 0028292294 scopus 로고
    • Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma
    • [91] N. Nishida, Y. Fukuda, T. Komeda, Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma, Cancer Res. 54 (1994) 3107-3110.
    • (1994) Cancer Res. , vol.54 , pp. 3107-3110
    • Nishida, N.1    Fukuda, Y.2    Komeda, T.3
  • 93
    • 0028843480 scopus 로고
    • Functional inactivation but not structural mutation of p53 causes liver cancer
    • [93] H. Ueda, S.J. Ullrich, J.D. Gangemi, Functional inactivation but not structural mutation of p53 causes liver cancer, Nat. Genet. 9 (1995) 41-47.
    • (1995) Nat. Genet. , vol.9 , pp. 41-47
    • Ueda, H.1    Ullrich, S.J.2    Gangemi, J.D.3
  • 94
    • 0025834677 scopus 로고
    • Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products
    • [94] S. Mashiyama, Y. Murakami, T. Yoshimoto, T. Sekiya, K. Hayashi, Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products, Oncogene 6 (1991) 1313-1318.
    • (1991) Oncogene , vol.6 , pp. 1313-1318
    • Mashiyama, S.1    Murakami, Y.2    Yoshimoto, T.3    Sekiya, T.4    Hayashi, K.5
  • 95
    • 0028879890 scopus 로고
    • Homozygous deletion of the MTS1 / p16 and MTS2 / p15 genes and amplification of the CDK4 gene in glioma
    • [95] Y. Sonoda, T. Yoshimoto, T. Sekiya, Homozygous deletion of the MTS1 / p16 and MTS2 / p15 genes and amplification of the CDK4 gene in glioma, Oncogene 11 (1995) 2145-2149.
    • (1995) Oncogene , vol.11 , pp. 2145-2149
    • Sonoda, Y.1    Yoshimoto, T.2    Sekiya, T.3
  • 98
    • 0032518924 scopus 로고    scopus 로고
    • Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas
    • [98] H. Kon, Y. Sonoda, T. Kumabe, T. Yoshimoto, T. Sekiya, Y. Murakami, Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas, Oncogene 16 (1998) 257-263.
    • (1998) Oncogene , vol.16 , pp. 257-263
    • Kon, H.1    Sonoda, Y.2    Kumabe, T.3    Yoshimoto, T.4    Sekiya, T.5    Murakami, Y.6
  • 100
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • [100] N. Rampino, H. Yamamoto, Y. Ionov, Y. Li, H. Sawai, J.C. Reed, M. Perucho M, Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype, Science 275 (1997) 967-969.
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3    Li, Y.4    Sawai, H.5    Reed, J.C.6    Perucho M, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.