Association study of alcoholism subtypes with a functional promoter polymorphism in the serotonin transporter protein gene

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 9, 2002, Pages 1330-1335

  Kranzler, Henry ^a,d   Lappalainen, Jaakko ^b,c   Nellissery, Maggie ^a   Gelernter, Joel ^b,c  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Alcoholism Subtypes; Genetics; Polymorphism; Serotonin Transporter

Indexed keywords

ALCOHOL; SEROTONIN; SEROTONIN TRANSPORTER;

ADULT; ALCOHOLISM; ALLELE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGRO; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION;

ADULT; AGE OF ONSET; ALCOHOLISM; ALLELES; CARRIER PROTEINS; COMORBIDITY; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); QUANTITATIVE TRAIT LOCI; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS; SUBSTANCE-RELATED DISORDERS;

EID: 0036738212     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-200209000-00004     Document Type: Article

References (52)

1. Babor TF, Dolinsky Z, Rounsaville B, Jaffe J (1988) Unitary versus multidimensional models of alcoholism treatment outcome: an empirical study. J Stud Alcohol 49:167-177.
2. Blouin AG, Perez EL, Blouin JH (1988) Computerized administration of the diagnostic interview schedule. Psychiatry Res 23:335-344.
3. Brent EE, Mirielli EJ, Thompson A (1993) Ex-sample: an expert system for determining sample size. Ver 3. Columbia, MO: Idea Works, Inc.
4. Buydens-Branchey L, Branchey MH, Noumair D (1989a) Age of alcoholism onset. I. Relationship to psychopathology. Arch Gen Psychiatry 46:225-230.
5. Buydens-Branchey L, Branchey MH, Noumair D, Lieber CS (1989b) Age of alcoholism onset. II. Relationship to susceptibility to serotonin precursor availability. Arch Gen Psychiatry 46:231-236.
6. Cubells JF, Kobayashi K, Nagatsu T, Kidd KK, Kidd JR, Calafell F, Kranzler HR, Ichinose H, Gelernter J (1997) Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH). Am J Med Genet 74:374-379.
7. Edenberg HJ, Reynolds J, Koller DL, Begleiter H, Bucholz KK, Conneally PM, Crowe R, Goate A, Hesselbrock V, Li TK, Nurnberger JI Jr, Porjesz B, Reich T, Rice JP, Schuckit M, Tischfield JA, Foroud T (1998) A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence. Alcohol Clin Exp Res 22:1080-1085.
8. Fernandez JR, Vogler GP, Tarantino LM, Vignetti S, Plomin R, McClearn GE (1999) Sex-exclusive quantitative trait loci influences in alcohol-related phenotypes. Am J Med Genet 88:647-652.
9. Fils-Aime ML, Eckardt MJ, George DT, Brown GL, Mefford I, Linnoila M (1996) Early-onset alcoholics have lower cerebral spinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics. Arch Gen Psychiatry 53:211-216.
10. Gelernter J, Kranzler H, Cubells J (1997) Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 101:243-246.
11. Gill K, Desaulniers N, Desjardins P, Lake K (1998) Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci. Mamm Genome 9:929-935.
12. Gorwood P, Batel P, Ades J, Hamon M, Boni C (2000) Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol Psychiatry 48:259-264.
13. Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL (1999) Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88:83-87.
14. Hallikainen T, Saito T, Lachman HM, Volavka J, Pohjalainen T, Ryynanen OP, Kauhanen J, Syvalahti E, Hietala J, Tiihonen J (1999) Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Mol Psychiatry 4:385-388.
15. Hammoumi S, Payen A, Favre JD, Balmes JL, Benard JY, Husson M, Ferrand JP, Martin JP, Daoust M (1999) Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence? Alcohol 17:107-112.
16. Heils A, Mossner R, Lesch KP (1997) The human serotonin transporter gene polymorphism-basic research and clinical implications. J Neural Transm 104:1005-1014.
17. Heils A, Tuefel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation in human serotonin transporter gene expression. J Neurochem 66:2621-2624.
18. Ishiguro H, Saito T, Akazawa S, Mitushio H, Tada K, Enomoto M, Mifune H, Toru M, Shibuya H, Arinami T (1999) Association between drinking-related antisocial behavior and a polymorphism in the serotonin transporter gene in a Japanese population. Alcohol Clin Exp Res 23:1281-1284.
19. Jacobson GR (1976) The Alcoholisms: Detection, Diagnosis, and Assessment. Human Sciences Press, New York.
20. Javors M, Tiouririne M, Prihoda T (2000) Platelet serotonin is higher in early-onset than in late-onset alcoholics. Alcohol Alcohol 35:390-393.
21. Johnson BA (2000) Serotonergic agents and alcoholism treatment: rebirth of the subtype concept - an hypothesis. Alcohol Clin Exp Res 24:1597-1601.
22. Kendler KS (2001) Twin studies of psychiatric illness: an update. Arch Gen Psychiatry 58:1005-1014.
23. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS (1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Arch Gen Psychiatry 51:8-19.
24. Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 5:561-567.
25. Kittles R, Long JC, Bergen AW, Eggert M, Virkkunen M, Linnoila M, Goldman D (1999) Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits. Proc Natl Acad Sci U S A 96:4204-4209.
26. Kotler M, Cohen H, Kremer I, Mel H, Horowitz R, Ohel N, Gritsenko I, Nemanov L, Katz M, Ebstein R (1999). No association between the serotonin transporter promoter region (5-HTTLPR) and the dopamine D3 receptor (Ball D3DR) polymorphisms and heroin addiction. Mol Psychiatry 4:313-314.
27. Kranzler HR, Del Boca FK, Rounsaville BJ (1996) Comorbid psychiatric diagnosis predicts three-year outcomes in alcoholics: a post-treatment natural history study. J Stud Alcohol 57:619-626.
28. LeMarquand D, Pihl RO, Benkelfat C (1994a) Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol Psychiatry 36:395-421.
29. LeMarquand D, Pihl RO, Benkelfat C (1994b) Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol Psychiatry 36: 326-337.
30. Lesch PK, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
31. Lichtermann D, Hranilovic D, Trixler M, Franke P, Jernej B, Delmo CD, Knapp M, Schwab SG, Maier W, Wildenauer DB (2000) Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcohol dependence. Am J Psychiatry 157:2045-2047.
32. Mash DC, Staley JK, Izenwasser S, Basile M, Ruttenber AJ (2000) Serotonin transporters upregulate with chronic cocaine use. J Chem Neuroanat 20:271-280.
33. Matsushita S, Yoshino A, Murayama M, Kimura M, Muramatsu T, Higuchi S (2001) Association study of serotonin transporter gene regulatory region polymorphism and alcoholism. Am J Med Genet 105:446-450.
34. McGue M, Pickens RW, Svikis DS (1992) Sex and age effects on the inheritance of alcohol problems: a twin study. J Abnorm Psychol 101: 3-17.
35. Melo J, Shendure J, Pociask K, Silver LM (1996) Identification of sex-specific QTLs controlling alcohol preference by C57BL/6 mice. Nat Genet 13:147-153.
36. Miller N (1991) Special problems of the alcohol and multiple-drug dependent: clinical interactions and detoxification, in Clinical Textbook of Addictive Disorders (Frances R, Miller S eds), pp 194-218. Guilford Press, New York.
37. Peirce JL, Derr R, Shendure J, Kolata T, Silver LM (1998) A major influence of sex-specific loci on alcohol preference in C57B1/6 and DBA/2 inbred mice. Mamm Genome 9:942-948.
38. Pettinati HM, Kranzler HR, Madaras J The status of serotonin-selective medications in the treatment of alcohol dependence, in Recent Developments in Alcoholism (Galanter M ed), vol 16, Kluwer Academic Publishers, Norwell, MA, in press.
39. Prescott CA, Aggen SH, Kendler KS (1999) Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins. Alcohol Clin Exp Res 23:1136-1144.
40. Preuss UW, Koller G, Soyka M, Bondy B (2001) Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects: further evidence from a German alcohol-dependent inpatient sample. Biol Psychiatry 50:636-639.
41. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK (1990) Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264:2511-2518.
42. Rounsaville BJ, Dolinsky ZS, Babor TF, Meyer RE (1987) Psychopathology as a predictor of treatment outcome in alcoholics. Arch Gen Psychiatry 44:505-513.
43. Rounsaville BJ, Weissman MM, Kleber HD (1982) The significance of alcoholism in treated opiate addicts. J Nerv Ment Dis 170:479-488.
44. Schuckit MA, Mazzanti C, Smith TL, Ahmed U, Radel M, Iwata N, Goldman D (1999) Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol Psychiatry 45:647-651.
45. Spitzer RL, Williams JB, Gibbon M, First MB (1992) The structured clinical interview for DSM-III-R (SCID) I: history, rational, and description. Arch Gen Psychiatry 49:624-629.
46. Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA, Little KY (2002) Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 114:230-234.
47. Swann AC, Johnson BA, Cloninger CR, Chen YR (1999) Relationships of plasma tryptophan availability to course of illness and clinical features of alcoholism: a preliminary study. Psychopharmacology 143:380-384.
48. Tan EC, Yeo BKL, Ho BKW, Tay AHN, Tan CH (1999) Evidence for an association between heroin dependence and a VNTR polymorphism at the serotonin transporter locus. Mol Psychiatry 4:215-217.
49. Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin YT, Lu RB, Yin SJ (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677-681.
50. Turker T, Sodmann R, Goebel U, Jatzke S, Knapp M, Lesch KP, Schuster R, Schutz H, Weiler G, Stober G (1998) High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. Neurosci Lett 248:147-150.
51. Wall TL, Peterson CM, Peterson KP, Johnson ML, Thomasson HR, Cole M, Ehlers CL (1997) Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase. Ann Intern Med 127:401-403.
52. Walsh DC, Hingson RW, Merrigan DM, Levenson SM, Cupples LA, Heeren T, Coffman GA, Becker CA, Barker TA, Hamilton SK, McGuire TG, Kelly CA (1991) A randomized trial of treatment options for alcohol-abusing workers. N Engl J Med 325:775-782.