Expression of cytochrome P450 3A7 in Escherichia coli: Effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase

Archives of Biochemistry and Biophysics

Volumn 346, Issue 1, 1997, Pages 81-90

  Gillam, Elizabeth M J ^a   Wunsch, Rebecca M ^a   Ueng, Yune Fang ^d,e   Shimada, Tsutomu ^b   Reilly, Paul E B ^a   Kamataki, Tetsuya ^c   Guengerich, F Peter ^d  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Bicistronic constructs; Fetal drug metabolism; Heterologous expression; Midazolam; P450 3A; P450 3A7

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG DETOXIFICATION; ENZYME ACTIVITY; ENZYME PURIFICATION; ESCHERICHIA COLI; FETUS LIVER; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BACTERIA (MICROORGANISMS); BOVINAE; ESCHERICHIA COLI; STAPHYLOCOCCUS PHAGE 3A;

EID: 0031259757     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1997.0286     Document Type: Article

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