Mechanisms of apoptosis in human retinal pigment epithelium induced by TNF-α in conditions of heavy metal ion deficiency

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 3, 2005, Pages 1039-1046

  Yang, Jun Hai ^a,b   Le, Wei Dong ^a   Basinger, Scott F ^a   Wu, Samuel M ^a   Yang, Chao Yuh ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Acucela Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CALCINEURIN INHIBITOR; CASPASE 3; CASPASE INHIBITOR; CHELATING AGENT; CYCLOSPORIN A; DACTINOMYCIN; DICHLORODIHYDROFLUORESCEIN DIACETATE; HEAVY METAL; HOE 33342; METAL ION; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; REACTIVE OXYGEN METABOLITE; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA; CARRIER PROTEIN; CASP3 PROTEIN, HUMAN; CASPASE; CYCLOSPORIN; ETHYLENEDIAMINE DERIVATIVE; FLUORESCENT DYE; ION CHANNEL; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;

ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; CARBOXYLATION; CELL DEATH; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; PHASE TRANSITION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL LINE; CELL MEMBRANE POTENTIAL; DRUG COMBINATION; DRUG EFFECT; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY;

APOPTOSIS; CASPASE 3; CASPASES; CELL LINE; CHELATING AGENTS; CYCLOSPORINE; DACTINOMYCIN; DRUG COMBINATIONS; ENZYME ACTIVATION; ETHYLENEDIAMINES; FLUORESCENT DYES; HUMANS; ION CHANNELS; MEMBRANE POTENTIALS; METALS, HEAVY; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PIGMENT EPITHELIUM OF EYE; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 16244413643     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0325     Document Type: Article

References (42)

1. Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol. 2003;3:745-756.
2. Bratton SB, MacFarlane M, Cain K, Cohen GM. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp Cell Res. 2000;256:27-33.
3. Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol. 1998;60:619-642.
4. Carter JE, Truong-Tran AQ, Grosser D, Ho L, Ruffin RE, Zalewski PD. Involvement of redox events in caspase activation in zinc-depleted airway epithelial cells. Biochem Biophys Res Commun. 2002;297:1062-1070.
5. Hyun HJ, Sohn JH, Ha DW, Ahn YH, Koh JY, Yoon YH. Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2001;42:460-465.
6. Kolenko VM, Uzzo RG, Dulin N, Hauzman E, Bukowski R, Finke JH. Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes. Apoptosis. 2001;6:419-429.
7. Tang ZL, Wasserloos K, St Croix CM, Pitt BR. Role of zinc in pulmonary endothelial cell response to oxidative stress. Am J Physiol. 2001;281:L243-L249.
8. Watjen W, Haase H, Biagioli M, Beyersmann D. Induction of apoptosis in mammalian cells by cadmium and zinc. Environ Health Perspect. 2002;110(suppl 5):865-867.
9. Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol. 1998;18:6353-6364.
10. van Gurp M, Festjens N, van Loo G, Saelens X, Vandenabeele P. Mitochondrial intermembrane proteins in cell death. Biochem Biophys Res Commun. 2002;304:487-497.
11. Wang JL, Liu D, Zhang ZJ, et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci. 2000;97:7124-7129.
12. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001;26:61-66.
13. Garg AK, Aggarwal BB. Reactive oxygen intermediates in TNF signaling. Mol Immunol. 2002;39:509-517.
14. Ricci JE, Gottlieb RA, Green DR. Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol. 2003;160:65-75.
15. Chen Q, Gong B, Almasan. Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis. Cell Death Differ. 2000;7:227-233.
16. Slee EA, Hasrte MT, Kluck RM, et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol. 1999;144:281-292.
17. Slee EA, Keogh SA, Martin SJ. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point Bcl-2 action and is catalyzed by caspase 3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell Death Differ. 2000;7:556-565.
18. D'Herde K, DE Prest B, Mussche S, et al. Ultrastructural localization of cytochrome c in apoptosis demonstrates mitochondrial heterogeneity. Cell Death Differ. 2000;7:331-337.
19. Keysko DV, Roels F, Leybaert L, D'Herde K. Mitochondrial transmembrane potential changes support the concept of mitochondrial heterogeneity during apoptosis. J Histochem Cytochem. 2001;49:1277-1284.
20. Babcock DF, Hille B. Mitochondrial oversight of cellular Ca2+ signaling. Curr Opin Neurobiol. 1998;8:398-404.
21. Cuajungco MP, Lees GJ. Zinc and Alzheimer's disease: is there a direct link? Brain Res Brain Res Rev. 1997;23:219-236.
22. Ugarte M, Osborne NN. Zinc in the retina. Prog Neurobiol. 2001; 64:219-249.
23. DeMoor JM, Koropatnick DJ. Metals and cellular signaling in mammalian cells. Cell Mol Biol (Noisy-le-Grand). 2000;46:367-381.
24. Marini M, Frabetti F, Canaider S, Dini L, Falcier E, Poirier GG. Modulation of caspase-3 activity by zinc ions and by the cell redox state. Exp Cell Res. 2001;266:323-332.
25. Hennig B, Meerarani P, Toborek M. McClain CJ. Antioxidant-like properties of zinc in activated endothelial cells. J Am Coll Nutr. 1999;18:152-158.
26. Szuster-Ciesielska A, Stachura A, Slotwinska M, et al. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology. 2000;145:159-171.
27. Sensi SL, Yin HZ, Weiss JH. AMPA/kainate receptor-triggered Zn2+ entry into cortical neurons induces mitochondrial Zn2+ uptake and persistent mitochondrial dysfunction: AMPA/kainate receptor-triggered Zn2+ entry into cortical neurons induces mitochondrial Zn2+ uptake and persistent mitochondrial dysfunction. Eur J Neurosci. 2000;12:3813-3818.
28. Lambert JC, Zhou Z, Kang YJ. Suppression of Fas-mediated signaling pathway is involved in zinc inhibition of ethanol-induced liver apoptosis. Exp Biol Med (Maywood). 2003;228:406-412.
29. Ferry-Dumazet H, Mamani-Matsuda M, Dupouy M, et al. Nitric oxide induces the apoptosis of human BCR-ABL-positive myeloid leukemia cells: evidence for the chelation of intracellular iron. Leukemia. 2002;16:708-715.
30. Feger F, Ferry-Dumazet H, Mamani Matsuda M, et al. Role of iron in tumor cell protection from the pro-apoptotic effect of nitric oxide. Cancer Res. 2001;61:5289-5294.
31. Chung KC, Park JH, Kim CH, et al. Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-kappaB, and MAP kinases. J Neurosci Res. 2000;59:117-125.
32. Li M, Xia T, Jiang CS, Li LJ, Fu JL, Zhou ZC. Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis. Toxicology. 2003;194:19-33.
33. Brustovetsky N, Dubinsky JM. Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria. J Neurosci. 2000;20:8229-8237.
34. Chinopoulos C, Starkov AA, Fiskum G. Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate. J Biol Chem. 2003;278:27382-27389.
35. Santos JB, Schauwecker PE. Protection provided by cyclosporin A against excitotoxic neuronal death is genotype dependent. Epilepsia. 2003;44:995-1002.
36. Sparrow JR, Zhou J, Ben-Shabat S, Vollmer H, Itagaki Y, Nakanishi K. Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE. Invest Ophthalmol Vis Sci. 2002;43: 1222-1227.
37. Sparrow JR, Vollmer-Snarr HR, Zhou J, et al. A2E-epoxides damage DNA in retinal pigment epithelial cells: vitamin E and other antioxidants inhibit A2E-epoxide formation. J Biol Chem. 2003;278: 18207-18213.
38. Grimble RF. Inflammatory response in the elderly. Curr Opin Clin Nutr Metab Care. 2003;6:21-29.
39. Arosio P, Levi S. Ferritin, iron homeostasis, and oxidative damage. Free Radic Biol Med. 2002;33:457-463.
40. Linder MC. Copper and genomic stability in mammals. Mutat Res. 2001;475:141-152.
41. O'Brien TJ, Ceryak S, Patierno SR. Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms. Mutat Res. 2003;533:3-36.
42. Roth JA, Garrick MD. Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol. 2003;66:1-13.