Down regulation of hepatic PPARα function by AhR ligand

Journal of Veterinary Medical Science

Volumn 66, Issue 11, 2004, Pages 1377-1386

  Shaban, Zein ^a,b   El Shazly, Samir ^b   Abdelhady, Shawky ^b   Fattouh, Ibrahim ^b   Muzandu, Kaampwe ^a   Ishizuka, Mayumi ^a   Kimura, Kazuhiro ^c   Kazusaka, Akio ^a   Fujita, Shoichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TANTA UNIVERSITY   (Egypt)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

AhR; CYP4A; PPAR rat; RXR

Indexed keywords

RATTUS NORVEGICUS;

AROMATIC HYDROCARBON RECEPTOR; AZO COMPOUND; CLOFIBRIC ACID; CYTOCHROME P450; MESSENGER RNA; OIL SCARLET; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; LIVER; MALE; METABOLISM; PHYSIOLOGY; RAT; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; AZO COMPOUNDS; CELL LINE, TUMOR; CLOFIBRIC ACID; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; LIVER; MALE; PPAR ALPHA; RATS; RATS, WISTAR; RECEPTORS, ARYL HYDROCARBON; RETINOID X RECEPTOR ALPHA; RNA, MESSENGER;

EID: 16244404002     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.66.1377     Document Type: Article

References (48)

1. Alexander, D.L., Ganetn, L.G., Fernandez-Salguero, P., Gonzalez, F. and Jefcoate, C.R. 1998. Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis. J. Cell. Sci. 111: 3311-3322.
2. Aasum, E., Belke, D.D., Severson, D.L., Riemersma. R.A., Cooper, M., Andreassen, M. and Larsen, T.S. 2002. Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a novel PPAR-alpha activator. Am. J. Physiol. Heart. Circ. Physiol 283: 949-957.
3. Auboeuf, D., Rieusset, J., Fajas, L., Vallier, P., Frering, V., Riou, J.P., Steels, B., Auwerx, J., Laville, M. and Vidal, H. 1997. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-[alpha] in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46: 1319-1327.
4. Blanquart, C., Barbier, O., Fruchart, J.C., Staels, B. and Glineur, C. 2002. Peroxisome proliferator-activated receptor alpha (PPAR alpha) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes. J. Biol. Chem. 277: 37254-37259.
5. Bocher, V., Pineda-Torra, I., Fruchart, J.C. and Staels, B. 2002. PPARs: transcription factors controlling lipid and lipoprotein metabolism. Ann. New York. Acad. Sci. 967: 7-18.
6. Chao, C., Youssef, J., Rezaiekhaleigh, M., Birnbaum, L.S. and Badr, M. 2002. Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxi some proliferator-activated receptor alpha. Mech. Ageing. Dev. 123: 1469-1476.
7. Dowell, P., Ishmael, J.E., Avram, D., Peterson, V.J., Nevrivy, D.J. and Leid, M. 1997. P300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha. J. Boil. Chem. 272: 33435-33443.
8. El-Sabeawy, F., Enan, E. and Lasley, B. 2001. Biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in immature male and female chickens. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 129: 317-327.
9. Feher, M.D., Caslake, M., Foxton, J., Cox, A. and Packard, C.J. 1999. Atherogenic lipoprotein phenotype in type 2 diabetes: reversal with micronised fenofibrate. Diabetes. Meta. Res. Rev. 6: 395-399.
10. Fernandez-Salguero, P.M., Hilbert, D.M., Rudikoff, S., Ward, J.M. and Gonzalez, F.J. 1996. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetra- chloro dibenzo-p-dioxin-induced toxicity. Toxicol. Appl. Pharmacol. 140: 173-179.
11. Franc, M.A., Pohjanvirta, R., Tuomisto, J. and Okey, A.B. 2001. In vivo Up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8- terra chlorodibenzo-p-dioxin-resistant rat model. Biochem. Pharmacol. 62: 1565-1578.
12. Franc, M.A., Pohjanvirta, R., Tuomisto, J. and Okey, A.B. 2001. Persistent, low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effect on aryl hydrocarbon receptor expression in a dioxin-resistance model. Toxicol. Appl. Pharmacol. 175: 43-53.
13. Geusau, A., Abraham, K., Geissler, K., Sator, MO., Stingl, G. and Tschachler, E. 2001. Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: Clinical and laboratory effects. Environ. Health. Perspect. 109: 865-869.
14. Fujita, S., Suzuki, M., Peisach, J. and Suzuki, T. 1984. Induction of hepatic microsomal drug metabolism by azo compounds: a structure-activity relationship. Chemico. Biol. Interact. 52: 15-37.
15. Hanlon, P.R., Ganem, L.G., Cho, Y.C., Yamamoto, M. and Jefcoate, C.R. 2003. AhR-and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gammal expression and subsequent adipocyte differentiation. Toxicol. Appl. Pharmacol. 189: 11-27.
16. Ikegwuonu, F.I. and Jefcoate, C.R. 1999. Evidence for the involvement of the fatty acid and peroxisomal beta-oxidation pathways in the inhibition by dehydroepiandrosterone (DHEA) and induction by 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) and benz(a)anthracene (BA) of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblasts (C3H10T1/2 cells) Mol .Cell .Biochem. 198: 89-100.
17. Johnson, E.F., Palmer, C.N., Griffin, K.J. and Hsu, M.H. 1996. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. FASEB J. 11: 1241-1248.
18. Ke, S., Rabson, A.B., Germino, J.F., Gallo, M.A. and Tian, Y. 2001. Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide. J. Boil. Chem. 276: 39638-39644.
19. Kersten, S., Mandard, S., Escher, P., Gonzalez, F.J., Tafuri, S., Desvergne, B. and Wahli, W. 2001. The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. FASEB. J. 11: 1971-1978.
20. Kobayashi, A., Numayama Tsuruta, K., Sogawa, K. and Fujii-Kuriyama, Y. 1997. CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). J. Biochem. (Tokyo) 122: 703-710.
21. Laemmli, U.K. 1970. Cleavge of structural protein during the assembly of the head of bacteriophage T4. Nature (Lond.) 227: 680-685.
22. Liu, P.C. and Matsumura, F. 1995. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the "adipose- type" and "brain-type" glucose transporters in mice. Mol. Pharmacol. 47: 65-73.
23. Lowry, O.H., Rosebrough, N.J., FaRR, A.L. and Randall, R.J. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275.
24. Marji, J.S., Wang, M.H. and Laniado-Schwartzman, M. 2002. Cytochrome P-450 4A isoform expressions and 20-HETE synthesis in renal preglomerular arteries. Am. J. Physiol. Renal Physiol. 283: 60-67.
25. Matsumura, F. 1995. Mechanism of action of dioxin-type chemicals, pesticides, and other xenobiotics affecting nutritional indexes. Am. J. Clin. Nutr. 61: 695S-701S.
26. Meyer, B.K. and Perdew, G.H. 1999. Characterization of the AHR-hsp90-XAP2 Core Complex and the Role of the Immunophilin-Related Protein XAP2 in AhR.
27. Murray, M., Sefton, R.M., Croft, K.D. and Butler, A.M. 2001. Differential regulation of endobiotic-oxidizing cytochromes P450 in vitamin A-deficient male rat liver. Br. J. Pharmacol. 134: 1487-1497.
28. Omura, T. and Sato, R. 1964. The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, Purification,and properties. J. Biol. Chem. 239: 2379-2385.
29. Pelclova, D., Fenclova, Z., Preiss, J., Prochazka, B., Spacil, J., Dubska, Z., Okrouhlik, B., Lukas, E. and Urban, P. 2002. Lipid metabolism and neuropsychological follow-up study of workers exposed to 2,3,7,8- tetrachlordibenzo- p-dioxin. Int. Arch. Occup. Environ. Health 75: 60-66.
30. Perdew, G.H. 1988. Association of the Ah receptor with the 90-kD a heat shock protein. J. Biol. Chem. 263: 13802-13805.
31. Potter, C.L., Menahan, L.A. and Peterson, R.E. 1986. Relationship of alterations in energy metabolism to hypophagia in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin Fundam. Appl. Toxicol. 6: 89-97.
32. Rahman, M., Wright, JT. Jr. and Douglas, J.G. 1997. The role of the cytochrome P450-dependent metabolites of arachidonic acid in blood pressure regulation and renal function. Am. J. Hypertens. 3: 356-365.
33. Remillard, R.B. and Bunce, N.J. 2002. Linking dioxins to diabetes: epidemiology and biologic plausibility Environ. Health. Perspect. 110: 853-858.
34. Rozman, K., Pfeifer, B., Kerecsen, L. and Alper, R.H. 1991. Is a serotonergic mechanism involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced appetite suppression in the Sprague-Dawley rat? Arch. Toxicol. 65: 124-128.
35. Schoonjans, K., Peinado-Onsurbe, J., Lefebvre, A.M., Heyman, R.A., Briggs, M., Deeb, S., Staels, B. and Auwerx, J. 1996. PPARalphα and PPARα activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO 19: 336-5348.
36. Shaban, Z., El-Shazly, S., Ishizuka, M., Kimura, K., Kazusaka, A. and Fujita, S. 2004. PPAR alpha-dependent modulation of hepatic CYP1A by clofibric acid in rats. Arch. Toxicol. (in press).
37. Shimba, S., Wada, T. and Tezuka, M. 2001. Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin. J. Cell. Sci. 114: 2809-2817.
38. Simpson, A.E. 1997. The cytochrome P450 4 (CYP4) family. Gen Pharmacol. 3: 351-359.
39. Smith, S.A. 1996. Peroxisome proliferator activated receptor (PPARs) Molecular targets for hypolipidaemic agents and insulin sensitizers. Pharmacol. Res. Commun. 8: 57-64.
40. Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E. and Fruchart, J.C. 1998. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 98: 2088-2093.
41. Sumanasekera, W.K., Tien, E.S., Turpey, R., Vanden, Heuvel, J.P. and Perdew, G.H. 2003. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J. Boil. Chem. 278: 4467-4473.
42. Sundseth, S.S. and Waxman, D. J. 1992. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. J. Biol. Chem. 267: 3915-3921.
43. Tomaszewski, K.E., Montgomery, C.A. and Melnick, R.L. 1988. Modulation of 2,3,7,8-tetrachlo rodibenzo-p-dioxin toxicity in F344 rats by di (2-ethylhexyl)phthalate. Chem. Biol. Interact. 65: 205-222.
44. Towbin, H., Staehelin, T. and Gordon, J. 1979. Electrophoresis transfer of proteins from Polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. U. S. A. 76: 4350-4354.
45. Vogel, C.F. and Matsumura, F. 2003. Interaction of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) with induced adipocyte differentiation in mouse embryonic fibroblasts (MEFs) involves tyrosine kinase c-Src. Biochem. Pharmacol. 66: 1231-1244.
46. Wang, M.H., Guan, H., Nguyen, X., Zand, B.A., Nasjletti, A. and Laniado-Schwartzman, M. 1999. Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20 hydroxy- eicosate traenoic acid synthesis in rat kidneys. Am. J. Physiol. 276: 246-253.
47. Wan, Y.J., Cai, Y., Lungo, W., Fu, P., Locker, J., French, S. and Sucov, H.M. 2000. Peroxisome proliferator-activated receptor alpha-mediated pathways are altered in hepatocyte-specific retinoid X receptor alpha-deficient mice. J. Biol. Chem. 275: 28285-28290.
48. Zhu, Y., Qi, C., Calandra, C., Rao, M.S. and Reddy, J.K. 1996. Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma. Gene. Expr. 6: 185-195.