Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis

Journal of Cell Science

Volumn 111, Issue 22, 1998, Pages 3311-3322

  Alexander, David L ^a   Ganem, Leonardo G ^a   Fernandez Salguero, Pedro ^b   Gonzalez, Frank ^b   Jefcoate, Colin R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Adipogenesis; Aryl hydrocarbon receptor (AhR); CYP1B1

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ACYL COENZYME A DESATURASE; AROMATIC HYDROCARBON RECEPTOR; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; EMBRYO; FIBROBLAST; GENE DISRUPTION; GENE EXPRESSION; GROWTH INHIBITION; HORMONAL REGULATION; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROADIPOCYTE; SENESCENCE;

ANIMALIA;

EID: 0031745543     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Alexander, D. L., Eltom, S. E. and Jefcoate, C. R. (1997). Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells. Cancer Res. 57, 4498-4506.
2. Altiok, S., Xu, M. and Spiegelman, B. M. (1997). PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev. 11, 1987-1998.
3. Belair, C. D., Blelloch, R. H. and Reznikoff, C. A. (1996). Immortalization of human uroepithelial cells by human papilomavirus 16 E6 or E7. Rad. Onc. Invest. 3, 368-376.
4. Brake, P. B. and Jefcoate, C. R.. (1995). Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3′,5′-monophosphate and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Endocrinology 136, 5034-5041.
5. Brodie, A. E., Azarenko, V. A. and Hu, C. Y. (1996). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibition of fat cell differentiation. Toxicol. Lett. 84, 55-59.
6. Brodie, A. E., Azarenko, V. A. and Hu, C. Y. (1997). Inhibition of increases of transcription factor mRNAs during differentiation of primary rat adipocytes by in vivo 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treatment. Toxicol. Lett. 90, 91-95.
7. Brun, R. P., Kim, J. B., Hu, E., Altiok, S. and Spiegelman, B. M. (1996). Adipocyte differentiation: a transcriptional regulatory cascade. Curr. Opin. Cell Biol. 8, 826-832.
8. Campisi, J. (1997). The biology of replicative senescence. Eur. J. Cancer 33, 703-709.
9. Chawla, A. and Lazar, M. A. (1994). Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc. Nat. Acad. Sci. USA 91, 1786-1790.
10. Chawla, A., Schwarz, E. J., Dimaculangan, D. D. and Lazar, M. A. (1994). Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135, 798-800.
11. Chen, C. L., Brodie, A. E. and Hu, C. Y. (1997). CCAAT/enhancer-binding protein beta is not affected by tetrachlorodibenzo-p-dioxin (TCDD) inhibition of 3T3-L1 preadipocyte differentiation. Obes. Res. 5, 146-152.
12. Chen, P. L., Riley, D. J., Chen, Y. and Lee, W. H. (1996). Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10, 2794-2804.
13. Christou, M., Keith, I. M., Shen, X., Schroeder, M. E. and Jefcoate, C. R. (1993). Reversal of cytochrome P-4501A1 and P-450-EF expression in MCA-C3H/10T1/2 cell-derived tumors as compared to cultured cells. Cancer Res. 53, 968-76.
14. Eltom, S. E., Larsen, M. C. and Jefcoate, C. R. (1998). Expression of Cyp1B1 but not Cyp1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor. Carcinogenesis (in press).
15. Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S., Kimura, S., Nebert, D., W., Rudikoff, S. Ward, J. M. and Gonzalez, F. J. (1995). Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor [see comments]. Science 268, 722-726.
16. Forman, B. M., Chen, J. and Evans, R. M. (1996). The peroxisome proliterator-activated receptors: ligands and activators. Ann. NY Acad. Sci. 804, 266-275.
17. Garces, C., Ruiz-Hidalgo, M. J., deMora, J. F., Park, C., Miele, L., Goldstein, J., Bonvini, E., Porras, A. and Laborda, J. (1997). Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J. Biol. Chem. 272, 29729-29734.
18. Green, H. and Meuth, M. (1974). An established pre-adipose cell line and its differentiation in culture. Cell 3, 127-33.
19. Hara, E., Uzman, J. A., Dimri, G. P., Nehlin, J. O., Testori, A. and Campisi, J. (1996). The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts. Dev. Genet. 18, 161-72.
20. Harlow, E. and Lane, D. (1988). Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Plainview, NY.
21. Harvey, M., Sands, A. T., Weiss, R. S., Hegi, M. E., Wiseman, R. W., Pantazis, P., Giovanella, B. C., Tainsky, M. A., Bradley, A. and Donehower, L. A. (1993). In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8, 2457-2467.
22. Harvey, M., Vogel, H., Morris, D., Bradley, A., Bernstein, A. and Donehower, L. A. (1995). A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat. Genetics 9, 305-311.
23. Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C. and Lehmann., J. M. (1995). A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83, 813-9.
24. Konieczny, S. F. and Emerson, C. P., Jr. (1984). 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination. Cell 38, 791-800.
25. Lemberger, T., Desvergne, B. and Wahli, W. (1996). Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Ann. Rev. Cell Dev. Biol. 12, 335-363.
26. Ma, Q. and Whitlock, J. P., Jr. (1996). The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Mol. Cell. Biol. 16, 2144-2150.
27. MacDougald, O. A. and Lane, M. D. (1995a). Adipocyte differentiation. When precursors are also regulators. Curr. Biol. 5, 618-621.
28. MacDougald, O. A. and Lane, M. D. (1995b). Transcriptional regulation of gene expression during adipocyte differentiation. Ann. Rev. Biochem. 64, 345-373.
29. Mandrup, S. and Lane, M. D. (1997). Regulating adipogenesis. J. Biol. Chem. 272, 5367-5370.
30. Miller, C. W., Casimir, D. A. and Ntambi, J. M. (1996). The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglandin F2alpha. Endocrinology 137, 5641-5650.
31. Miller, C. W. and Ntambi, J. M. (1996). Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc. Nat. Acad. Sci. USA 93, 9443-9448.
32. 2+ in the early stages of murine adipocyte differentiation as evidenced by calcium mobilizing agents. Differentiation 60, 151-158.
33. Phillips, M., Enan, E., Liu, P. C. and Matsumura, F. (1995). Inhibition of 3T3-L1 adipose differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Cell Sci. 108, 395-402.
34. Potter, C. L., Menahan, L. A. and Peterson, R. E. (1986). Relationship of alterations in energy metabolism to hypophagia in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fund. App Tox. 6, 89-97.
35. Probst, M. R., Reisz-Porszasz, S., Agbunag, R. V., Ong, M. S. and Hankinson, O. (1993). Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Mol. Pharm. 44, 511-518.
36. Reznikoff, C. A., Brankow, D. W. and Heidelberger, C. (1973). Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res. 33, 3231-3238.
37. Rowlands, J. C. and Gustafsson, J. A. (1947). Aryl hydrocarbon receptor-mediated signal transduction. Crit. Rev. Tox. 27, 109-134.
38. Sadek, C. M. and Allen-Hoffmann, B. L. (1994). Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway. J. Biol. Chem. 269, 31505-31509.
39. Savas, U., Bhattacharyya, K. K., Christou, M., Alexander, D. L. and Jefcoate, C. R. (1994). Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination and tissue expression. J. Biol. Chem. 269, 14905-14911.
40. Savas, U., Carstens, C. P. and Jefcoate, C. R. (1997). Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1. Arch. Biochem. Biophys. 347, 181-192.
41. Schmidt, J. V. and Bradfield, C. A. (1996). Ah receptor signaling pathways. Ann. Rev. Cell Dev. Biol.. 12, 55-89.
42. Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C. and Bradfield, C. A. (1996). Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc. Nat. Acad. Sci USA 93, 6731-6736.
43. Schwarz, E. J., Reginato, M. J., Shao, D., Krakow, S. L. and Lazar, M. A. (1997). Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription. Mol. Cell. Biol. 17, 1552-1561.
44. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. and Lowe, S. W. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.
45. Shay, J. W., Wright, W. E., Brasiskyte, D. and Van der Haegen, B. A. (1993). E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 8, 1407-13.
46. Shugart, E. C., Levenson, A. S., Constance, C. M. and Umek, R. M. (1995). Differential expression of gas and gadd genes at distinct growth arrest points during adipocyte development. Cell Growth Diff. 6, 1541-1547.
47. Shugart, E. C. and Umek, R. M. (1997). Dexamethasone signaling is required to establish the postmitotic state of adipocyte development. Cell Growth Diff. 8, 1091-1098.
48. Spiegelman, B. M. (1997). Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity. Euro. J. Med. Res. 2, 457-464.
49. Spiegelman, B. M. and Flier, J. S. (1996). Adipogenesis and obesity: founding out the big picture. Cell 87, 377-389.
50. Stoilov, I., Akarsu, A. N. and Sarfarazi, M. (1997). Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Human Mol. Gen. 6, 641-647.
51. Swanson, H. I., Chan, W. K. and Bradfield, C. A. (1995). DNA binding specificities and pairing rules of the Ah receptor, ARNT and SIM proteins. J. Biol. Chem. 270, 26292-26302.
52. Taylor, S. M. and Jones, P. A. (1979). Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell. 17, 771-779.
53. Tontonoz, P., Hu, E. and Spiegelman, B. M. (1994). Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79, 1147-1156.
54. Wu, Z., Xie, Y., Bucher, N. L. R. and Farmer, S. R. (1995). Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis. Genes Dev. 9, 2350-2363.
55. Xing, H., Northrop, J. P., Grove, J. R., Kilpatrick, K. E., Su, J. L. and Ringold, G. M. (1997). TNFα-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression. Endocrinology 138, 2776-2783.
56. Yeh, W. C., Cao, Z., Classon, M. and McKnight, S. L. (1995). Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9, 168-181.
57. Zhang, L., Savas, U., Alexander, D. L. and Jefcoate, C. R. (1998). Characterization of the Mouse CYP1B1 Gene. J. Biol. Chem. 273, 5174-5183.
58. Zhu, Y., Qi, C., Korenberg, J. R., Chen, X. N., Noya, D., Rao, M. S. and Reddy, J. K. (1995). Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPARγ) gene: alternative promoter use and different splicing yield two mPPARγ isoforms. Proc. Nat. Acad. Sci. USA 92, 7921-7925.