-
1
-
-
1842578074
-
Industrial methods for the production of optically active intermediates
-
M. Breuer, K. Ditrich, T. Habicher, B. Hauer, M. Kesseler, R. Stürmer, and T. Zelinski Industrial methods for the production of optically active intermediates Angew Chem Int Ed Engl 43 2004 788 824 Comprehensive review on industrial manufacturing of chiral intermediates using classical resolution approaches, biocatalysis as well as chemical catalysis.
-
(2004)
Angew Chem Int Ed Engl
, vol.43
, pp. 788-824
-
-
Breuer, M.1
Ditrich, K.2
Habicher, T.3
Hauer, B.4
Kesseler, M.5
Stürmer, R.6
Zelinski, T.7
-
2
-
-
3543087310
-
Trends and innovations in industrial biocatalysis for the production of fine chemicals
-
S. Panke, M. Held, and M.G. Wubbolts Trends and innovations in industrial biocatalysis for the production of fine chemicals Curr Opin Biotechnol 15 2004 272 279
-
(2004)
Curr Opin Biotechnol
, vol.15
, pp. 272-279
-
-
Panke, S.1
Held, M.2
Wubbolts, M.G.3
-
3
-
-
16244370883
-
Biocatalytic approaches for the large-scale production of asymmetric synthons
-
H.U. Blaser E.S. Schmidt Wiley-VCH
-
N.M. Shaw, K.T. Robbins, and A. Kiener Biocatalytic approaches for the large-scale production of asymmetric synthons H.U. Blaser E.S. Schmidt Asymmetric Catalysis on Industrial Scale 2004 Wiley-VCH 105 115
-
(2004)
Asymmetric Catalysis on Industrial Scale
, pp. 105-115
-
-
Shaw, N.M.1
Robbins, K.T.2
Kiener, A.3
-
4
-
-
4644241379
-
Challenges in the development of an efficient enzymatic process in the pharmaceutical industry
-
D.R. Yasbeck Challenges in the development of an efficient enzymatic process in the pharmaceutical industry Tetrah Asymmetry 15 2004 2757 2763
-
(2004)
Tetrah Asymmetry
, vol.15
, pp. 2757-2763
-
-
Yasbeck, D.R.1
-
5
-
-
0038638237
-
Enzymatic synthesis of chiral intermediates for pharmaceuticals
-
R. Patel, R. Hanson, A. Goswami, V. Nanduri, A. Banerjee, M.-J. Donovan, S. Goldberg, R. Johnston, D. Brzozowski, and T. Tully Enzymatic synthesis of chiral intermediates for pharmaceuticals J Ind Microbiol Biotechnol 30 2003 252 259
-
(2003)
J Ind Microbiol Biotechnol
, vol.30
, pp. 252-259
-
-
Patel, R.1
Hanson, R.2
Goswami, A.3
Nanduri, V.4
Banerjee, A.5
Donovan, M.-J.6
Goldberg, S.7
Johnston, R.8
Brzozowski, D.9
Tully, T.10
-
6
-
-
12344273661
-
Chemoenzymatic synthesis of building blocks for statin side chains
-
M. Müller Chemoenzymatic synthesis of building blocks for statin side chains Angew Chem Int Ed Engl 44 2005 362 365 Excellent review on chemoenzymatic routes towards HMGCoA reductase inhibitors.
-
(2005)
Angew Chem Int Ed Engl
, vol.44
, pp. 362-365
-
-
Müller, M.1
-
8
-
-
85030794158
-
-
Halohydrin dehalogenases and method for production of 4-cyano-3-hydroxybutyric acid esters and amides. WO 2004/015132, (Codexis Inc.).
-
Davis SC, Grate JH, Gray DR, Gruber JM, Huisman GW, Ma SK, Newman LM, Sheldon R, Wang LA: Halohydrin dehalogenases and method for production of 4-cyano-3-hydroxybutyric acid esters and amides. WO 2004/015132, (Codexis Inc.).
-
-
-
Davis, S.C.1
Grate, J.H.2
Gray, D.R.3
Gruber, J.M.4
Huisman, G.W.5
Ma, S.K.6
Newman, L.M.7
Sheldon, R.8
Wang, L.A.9
-
9
-
-
4344663593
-
Exploring nitrilase sequence space for enantioselective catalysis
-
D.E. Robertson, J.A. Chaplin, G. DeSantis, M. Podar, M. Madden, E. Chi, T. Richardson, A. Milan, M. Miller, and D.P. Weiner Exploring nitrilase sequence space for enantioselective catalysis Appl Environ Microbiol 70 2004 2429 2436
-
(2004)
Appl Environ Microbiol
, vol.70
, pp. 2429-2436
-
-
Robertson, D.E.1
Chaplin, J.A.2
Desantis, G.3
Podar, M.4
Madden, M.5
Chi, E.6
Richardson, T.7
Milan, A.8
Miller, M.9
Weiner, D.P.10
-
10
-
-
0141645603
-
Creation of a productive, highly enantioselective nitrilase through gene site saturation mutagenesis (GSSM)
-
G. Desantis, K. Wong, B. Farwell, K. Chatman, Z. Zhu, G. Tomlinson, H. Huang, X. Tan, L. Bibbs, and P. Chen Creation of a productive, highly enantioselective nitrilase through gene site saturation mutagenesis (GSSM) J Am Chem Soc 125 2003 11476 11477 Illustrating the power of directed evolution to adapt enzymes to conditions that are required in industrial processes (high selectivity, productivity and concentrations).
-
(2003)
J Am Chem Soc
, vol.125
, pp. 11476-11477
-
-
Desantis, G.1
Wong, K.2
Farwell, B.3
Chatman, K.4
Zhu, Z.5
Tomlinson, G.6
Huang, H.7
Tan, X.8
Bibbs, L.9
Chen, P.10
-
11
-
-
0242607602
-
Chemo-enzymatic approach to statin side-chain building blocks
-
R. Öhrlein, and G. Baisch Chemo-enzymatic approach to statin side-chain building blocks Adv Synth Catal 345 2003 713 715 Deracemization with cheaply available enzymes to catalyze the synthesis of statin side chains.
-
(2003)
Adv Synth Catal
, vol.345
, pp. 713-715
-
-
Öhrlein, R.1
Baisch, G.2
-
12
-
-
85030796566
-
-
Process for the preparation of 2,4-dideoxyhexoses and therapeutic uses thereof. WO 2003/006656, (DSM).
-
Kierkels JGT, Mink D, Panke S, Lommen FAM, Heemskerk D: Process for the preparation of 2,4-dideoxyhexoses and therapeutic uses thereof. WO 2003/006656, (DSM).
-
-
-
Kierkels, J.G.T.1
Mink, D.2
Panke, S.3
Lommen, F.A.M.4
Heemskerk, D.5
-
13
-
-
1942469509
-
Development of an efficient, scalable, aldolase catalyzed process for enantioselective synthesis of statin intermediates
-
W.A. Greenberg, A. Varvak, S.R. Hanson, K. Wong, H. Huang, P. Chen, and M.J. Burk Development of an efficient, scalable, aldolase catalyzed process for enantioselective synthesis of statin intermediates Proc Natl Acad Sci USA 101 2004 5788 5793
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 5788-5793
-
-
Greenberg, W.A.1
Varvak, A.2
Hanson, S.R.3
Wong, K.4
Huang, H.5
Chen, P.6
Burk, M.J.7
-
14
-
-
0037413355
-
Structure-based mutagenesis approaches towards expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase
-
G. DeSantis, J. Liu, D.P. Clark, A. Heine, I.A. Wilson, and C.-H. Wong Structure-based mutagenesis approaches towards expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase Bioorg Med Chem 11 2003 43 52 Use of high-resolution 3D structure information to construct mutants of an enzyme that can accommodate a new substrate. Potential new route to atorvastatin (see also [15]).
-
(2003)
Bioorg Med Chem
, vol.11
, pp. 43-52
-
-
Desantis, G.1
Liu, J.2
Clark, D.P.3
Heine, A.4
Wilson, I.A.5
Wong, C.-H.6
-
15
-
-
1242331787
-
Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin
-
J. Liu, C.-C. Hsu, and C.-H. Wong Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin Tetrahedron Lett 45 2004 2439 2441
-
(2004)
Tetrahedron Lett
, vol.45
, pp. 2439-2441
-
-
Liu, J.1
Hsu, C.-C.2
Wong, C.-H.3
-
16
-
-
1342267386
-
Production of L-phenylacetyl carbinol by immobilized cells of Saccharomyces cerevisiae
-
A.K. Mandwal, C.K.M. Tripathi, P.D. Trivedi, A.K. Joshi, S.C. Agarwal, and V. Bihari Production of L-phenylacetyl carbinol by immobilized cells of Saccharomyces cerevisiae Biotechnol Lett 26 2004 217 221
-
(2004)
Biotechnol Lett
, vol.26
, pp. 217-221
-
-
Mandwal, A.K.1
Tripathi, C.K.M.2
Trivedi, P.D.3
Joshi, A.K.4
Agarwal, S.C.5
Bihari, V.6
-
17
-
-
18144450522
-
Enhanced production of R-phenylacetylcarbinol (R-PAC) through enzymatic biotransformation
-
B. Rosche, V. Sandford, M. Breuer, B. Hauer, and P.L. Rogers Enhanced production of R-phenylacetylcarbinol (R-PAC) through enzymatic biotransformation J Mol Catal B Enzym 19-20 2002 109 115
-
(2002)
J Mol Catal B Enzym
, vol.19-20
, pp. 109-115
-
-
Rosche, B.1
Sandford, V.2
Breuer, M.3
Hauer, B.4
Rogers, P.L.5
-
18
-
-
2942538028
-
Biphasic aqueous/organic biotransformation of acetaldehyde and benzaldehyde by Zymomonas mobilis pyruvate decarboxylase
-
B. Rosche, M. Breuer, B. Hauer, and P.L. Rogers Biphasic aqueous/organic biotransformation of acetaldehyde and benzaldehyde by Zymomonas mobilis pyruvate decarboxylase Biotechnol Bioeng 86 2004 788 794 Excellent example of how even a well-established process can be improved by a change of enzyme system and process development.
-
(2004)
Biotechnol Bioeng
, vol.86
, pp. 788-794
-
-
Rosche, B.1
Breuer, M.2
Hauer, B.3
Rogers, P.L.4
-
19
-
-
1442326106
-
Process strategies to enhance pyruvate production with recombinant Escherichia coli: From repetitive fed-batch to in situ product recovery with fully integrated electrodialysis
-
B. Zelic, S. Gostovic, K. Vuorilehto, D. Vasic-Racki, and R. Takors Process strategies to enhance pyruvate production with recombinant Escherichia coli: from repetitive fed-batch to in situ product recovery with fully integrated electrodialysis Biotechnol Bioeng 85 2004 638 646
-
(2004)
Biotechnol Bioeng
, vol.85
, pp. 638-646
-
-
Zelic, B.1
Gostovic, S.2
Vuorilehto, K.3
Vasic-Racki, D.4
Takors, R.5
-
21
-
-
2242421831
-
High-throughput assay of (R)-phenylacetylcarbinol synthesized by pyruvate decarboxylase
-
M. Breuer, M. Pohl, B. Hauer, and B. Lingen High-throughput assay of (R)-phenylacetylcarbinol synthesized by pyruvate decarboxylase Anal Bioanal Chem 374 2002 1069 1073
-
(2002)
Anal Bioanal Chem
, vol.374
, pp. 1069-1073
-
-
Breuer, M.1
Pohl, M.2
Hauer, B.3
Lingen, B.4
-
22
-
-
1642457254
-
Metabolic engineering for microbial production of shikimic acid
-
M. Krämer, J. Bongaerts, R. Bovenberg, S. Kremer, U. Müller, S. Orf, M. Wubbolts, and L. Raeven Metabolic engineering for microbial production of shikimic acid Metab Eng 5 2003 277 283
-
(2003)
Metab Eng
, vol.5
, pp. 277-283
-
-
Krämer, M.1
Bongaerts, J.2
Bovenberg, R.3
Kremer, S.4
Müller, U.5
Orf, S.6
Wubbolts, M.7
Raeven, L.8
-
23
-
-
2542536213
-
Synthesis of aminoshikimic acid
-
J. Guo, and J.W. Frost Synthesis of aminoshikimic acid Org Lett 6 2004 1585 1588 From solving the enigma on the biosynthesis of aminoshikimic acid as present in natural products towards a means to produce the molecule.
-
(2004)
Org Lett
, vol.6
, pp. 1585-1588
-
-
Guo, J.1
Frost, J.W.2
-
24
-
-
3042777950
-
Creation of a shikimate pathway variant
-
N. Ran, K. Draths, and J.W. Frost Creation of a shikimate pathway variant J Am Chem Soc 126 2004 6856 6857 First example of engineering a new link between central carbon metabolism and the shikimic pathway, aimed at solving limitations in PEP flux due to the PTS sugar transport system.
-
(2004)
J Am Chem Soc
, vol.126
, pp. 6856-6857
-
-
Ran, N.1
Draths, K.2
Frost, J.W.3
-
25
-
-
10744220102
-
(S,S)-2,3-dihydroxy-2,3-dihydrobenzoic acid: Microbial access with engineered cells of Escherichia coli and application as starting material in natural product synthesis
-
D. Franke, V. Lorbach, S. Esser, C. Dose, G.A. Sprenger, M. Halfar, J. Thömmes, R. Müller, R. Takors, and M. Müller (S,S)-2,3-dihydroxy- 2,3-dihydrobenzoic acid: microbial access with engineered cells of Escherichia coli and application as starting material in natural product synthesis Chem Eur J 9 2003 4188 4196
-
(2003)
Chem Eur J
, vol.9
, pp. 4188-4196
-
-
Franke, D.1
Lorbach, V.2
Esser, S.3
Dose, C.4
Sprenger, G.A.5
Halfar, M.6
Thömmes, J.7
Müller, R.8
Takors, R.9
Müller, M.10
-
26
-
-
0041467512
-
Easy access to (R,R)-3,4-dihydroxy-3,4-dihydrobenzoic acid with engineered strains of Escherichia coli
-
D. Franke, G.A. Sprenger, and M. Müller Easy access to (R,R)-3,4-dihydroxy-3,4-dihydrobenzoic acid with engineered strains of Escherichia coli ChemBioChem 4 2003 775 777
-
(2003)
ChemBioChem
, vol.4
, pp. 775-777
-
-
Franke, D.1
Sprenger, G.A.2
Müller, M.3
-
27
-
-
0037385630
-
Semisynthetic production of unnatural L-α-amino acids by metabolic engineering of the cysteine-biosynthetic pathway
-
T.H.P. Maier Semisynthetic production of unnatural L-α-amino acids by metabolic engineering of the cysteine-biosynthetic pathway Nat Biotechnol 21 2003 422 427 Both by metabolically engineering the cysteine pathway of E. coli and by feeding precursors to the fermentation process, new routes to intermediates of potential pharmaceutical interest were obtained.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 422-427
-
-
Maier, T.H.P.1
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