Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine

Neuropsychopharmacology

Volumn 30, Issue 4, 2005, Pages 821-832

  Oswald, Lynn M ^a   Wong, Dean F ^a   McCaul, Mary ^a   Zhou, Yun ^a   Kuwabara, Hiroto ^a   Choi, Leena ^b   Brasic, James ^a   Wand, Gary S ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c Ross Research Building ^*  (United States)

Author keywords

Amphetamine; Cortisol; Dopamine; Human; Positron emission tomography (PET); Reinforcement

Indexed keywords

ALCOHOL; AMPHETAMINE; CARBON 11; DOPAMINE; GLUCOCORTICOID; GROWTH HORMONE; HYDROCORTISONE; PLACEBO; RACLOPRIDE; SODIUM CHLORIDE;

ARTICLE; BRAIN FUNCTION; CAUDATE NUCLEUS; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG DEPENDENCE; DRUG EFFECT; FEMALE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; REINFORCEMENT;

ADOLESCENT; ADULT; AFFECT; AMPHETAMINE; AMPHETAMINE-RELATED DISORDERS; CARBON RADIOISOTOPES; CAUSALITY; DOPAMINE; DOPAMINE ANTAGONISTS; FEMALE; FUNCTIONAL LATERALITY; GROWTH HORMONE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; NEOSTRIATUM; POSITRON-EMISSION TOMOGRAPHY; RACLOPRIDE; REWARD; STRESS;

EID: 15444373514     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300667     Document Type: Article

References (110)

1. Alessi SM, Greenwald M, Johanson CE (2003). The prediction of individual differences in response to D-amphetamine in healthy adults. Behav Pharmacol 14: 19-32.
2. Backman L, Ginovart N, Dixon RA, Wahlin TB, Wahlin A, Halldin C et al (2000). Age-related cognitive deficits mediated by changes in the striatal dopamine system. Am J Psychiatry 157: 635-637.
3. Barrot M, Abrous DN, Marinelli M, Rouge-Pont F, Le Moal M, Piazza PV (2001). Influence of glucocorticoids on dopaminergic transmission in the rat dorsolateral striatum. Eur J Neurosci 13: 812-818.
4. Barrot M, Marinelli M, Abrous DN, Rouge-Pont F, Le Moal M, Piazza PV (2000). The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent. Eur J Neurosci 12: 973-979.
5. Bau CH, Almeida S, Hutz MH (2000). The TaqI A1 allele of the dopamine D2 receptor gene and alcoholism in Brazil: association and interaction with stress and harm avoidance on severity prediction. Am J Med Genet 96: 302-306.
6. Baumann B, Danos P, Krell D, Diekmann S, Leschinger A, Stauch R et al (1999). Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study. J Neuropsychiatry Clin Neurosci 11: 71-78.
7. Bigelow G, Walsh S (1998). Evaluation of potential pharmacotherapies: response to cocaine challenge in the human laboratory. In: Higgins S, Katz J (eds). Cocaine Abuse: Behavior, Pharmacology and Clinical Applications. Academic Press: New York. pp 209-238.
8. Bonci A, Bernardi G, Grillner P, Mercuri NB (2003). The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction? Trends Pharmacol Sci 24: 172-177.
9. Brewer DD, Catalano RF, Haggerty K, Gainey RR, Fleming CB (1998). A meta-analysis of predictors of continued drug use during and after treatment for opiate addiction. Addiction 93: 73-92.
10. Broadbear JH, Winger G, Woods JH (1999). Cocaine-reinforced responding in rhesus monkeys: pharmacological attenuation of the hypothalamic-pituitary- adrenal axis response. J Pharmacol Exp Ther 290: 1347-1355.
11. Brown SA, Vik PW, McQuaid JR, Patterson TL, Irwin MR, Grant I (1990). Severity of psychosocial stress and outcome of alcoholism treatment. J Abnorm Psychol 99: 344-348.
12. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger Jr JI et al (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol 55: 149-158.
13. Cadoni C, Solinas M, Valentini V, Di Chiara G (2003). Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamine. Eur J Neurosci 18: 2326-2334.
14. Campbell UC, Carroll ME (2001). Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats. Psychopharmacology (Berl) 154: 311-318.
15. Cho K, Little HJ (1999). Effects of corticosterone on excitatory amino acid responses in dopamine-sensitive neurons in the ventral tegmental area. Neuroscience 88: 837-845.
16. Cole G, Tucker L, Friedman GM (1990). Relationships among measures of alcohol drinking behavior, life-events and perceived stress. Psychol Rep 67: 587-591.
17. Collignon A, Maes F, Delaere D, Vandermeulen D, Suetens P, Marchal G (1995). Automated multi-modality image registration based on information theory. In: Bizais Y, Barillot C, Di Paola R (eds). Proceedings Information Processing in Medical Imaging. Kluwer Academic Publishers: Dordrecht, The Netherlands. pp 263-274.
18. Cuadra G, Zurita A, Gioino G, Molina V (2001). Influence of different antidepressant drugs on the effect of chronic variable stress on restraint-induced dopamine release in frontal cortex. Neuropsychopharmacology 25: 384-394.
19. Dai X, Thavundayil J, Gianoulakis C (2002a). Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family history. Alcohol Clin Exp Res 26: 1171-1180.
20. Dai X, Thavundayil J, Gianoulakis C (2002b). Response of the hypothalamic-pituitary-adrenal axis to stress in the absence and presence of ethanol in subjects at high and low risk of alcoholism. Neuropsychopharmacology 27: 442-452.
21. Deroche V, Marinelli M, Maccari S, Le Moal M, Simon H, Piazza PV (1995). Stress-induced sensitization and glucocorticoids. I. Sensitization of dopamine-dependent locomotor effects of amphetamine and morphine depends on stress-induced corticosterone secretion. J Neurosci 15: 7181-7188.
22. Deroche V, Marinelli M, Le Moal M, Piazza PV (1997). Glucocorticoids and behavioral effects of psychostimulants. II: cocaine intravenous self-administration and reinstatement depend on glucocorticoid levels. J Pharmacol Exp Ther 281: 1401-1407.
23. de Wit H, Soderpalm AH, Nikolayev L, Young E (2003). Effects of acute social stress on alcohol consumption in healthy subjects. Alcohol Clin Exp Res 27: 1270-1277.
24. Doyon WM, York JL, Diaz LM, Samson HH, Czachowski CL, Gonzales RA (2003). Dopamine activity in the nucleus accumbens during consummatory phases of oral ethanol self-administration. Alcohol Clin Exp Res 27: 1573-1582.
25. Drevets WC, Gautier C, Price JC, Kupfer DJ, Kinahan PE, Grace AA et al (2001). Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol Psychiatry 49: 81-96.
26. Elman I, Lukas SE, Karlsgodt KH, Gasic GP, Breiter HC (2003). Acute cortisol administration triggers craving in individuals with cocaine dependence. Psychopharmacol Bull 37: 84-89.
27. Endres CJ, Kolachana BS, Saunders RC, Su T, Weinberger D, Breier A et al (1997). Kinetic modeling of [11C]raclopride: combined PET-microdialysis studies. J Cereb Blood Flow Metab 17: 932-942.
28. Erb S, Shaham Y, Stewart J (1996). Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology (Berl) 128: 408-412.
29. Errico AL, King AC, Lovallo WR, Parsons OA (2002). Cortisol dysregulation and cognitive impairment in abstinent male alcoholics. Alcohol Clin Exp Res 26: 1198-1204.
30. Fahlke C, Engel JA, Eriksson CJ, Hard E, Soderpalm B (1994). Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol 11: 195-202.
31. Friston KJ. http://www.fil.ion.ucl.ac.uk/spm.2002. electronic citation.
32. Goeders NE, Clampitt DM (2002). Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats. Psychopharmacology (Berl) 161: 222-232.
33. Goeders NE, Guerin GF (1996a). Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats. Brain Res 722: 145-152.
34. Goeders NE, Guerin GF (1996b). Role of corticosterone in intravenous cocaine self-administration in rats. Neuroendocrinology 64: 337-348.
35. Halbreich U, Sachar EJ, Asnis GM, Nathan RS, Halpern FS (1981). Diurnal cortisol responses to dextroamphetamine in normal subjects. Psychoneuroendocrinology 6: 223-229.
36. Harris DS, Reus VI, Wolkowitz OM, Mendelson JE, Jones RT (2003). Altering cortisol level does not change the pleasurable effects of methamphetamine in humans. Neuropsychopharmacology 28: 1677-1684.
37. Hearn AJ, Gallagher P, Owen BM, Smith MS, Watson S, Young AH (2004). Effect of sub-chronic hydrocortisone on responses to amphetamine in normal male volunteers. Psychopharmacology (Berl) 171: 458-464.
38. Howell LL, Wilcox KM (2002). Functional imaging and neurochemical correlates of stimulant self-administration in primates. Psychopharmacology (Berl) 163: 352-361.
39. Hull JG, Young RD (1983). Self-consciousness, self-esteem, and success-failure as determinants of alcohol consumption in male social drinkers. J Pers Soc Psychol 44: 1097-1109.
40. Jacobs D, Silverstone T, Rees L (1989). The neuroendocrine response to oral dextroamphetamine in normal subjects. Int Clin Psychopharmacol 4: 135-147.
41. Karlsgodt KH, Lukas SE, Elman I (2003). Psychosocial stress and the duration of cocaine use in non-treatment seeking individuals with cocaine dependence. Am J Drug Alcohol Abuse 29: 539-551.
42. Kemper A, Koalick F, Thiele H, Retzow A, Rathsack R, Nickel B (1990). Cortisol and beta-endorphin response in alcoholics and alcohol abusers following a high naloxone dosage. Drug Alcohol Depend 25: 319-326.
43. King AC, Bernardy NC, Hauner K (2003). Stressful events, personality, and mood disturbance: gender differences in alcoholics and problem drinkers. Addict Behav 28: 171-187.
44. King AC, Schluger J, Gunduz M, Borg L, Perret G, Ho A et al (2002). Hypothalamic-pituitary-adrenocortical (HPA) axis response and biotransformation of oral naltrexone: preliminary examination of relationship to family history of alcoholism. Neuropsychopharmacology 26: 778-788.
45. Koenig HN, Olive MF (2004). The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditions. Psychoneuroendocrinology 29: 999-1003.
46. Koob GF (1992). Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 13: 177-184.
47. Koob GF (2003). Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 27: 232-243.
48. Kosten TA, Ambrosio E (2002). HPA axis function and drug addictive behaviors: insights from studies with Lewis and Fischer 344 inbred rats. Psychoneuroendocrinology 27: 35-69.
49. Kosten TA, Zhang XY, Kehoe P (2003). Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups. Brain Res Dev Brain Res 141: 109-116.
50. Kosten TR, Oliveto A, Sevarino KA, Gonsai K, Feingold A (2002). Ketoconazole increases cocaine and opioid use in methadone maintained patients. Drug Alcohol Depend 66: 173-180.
51. Kreek MJ, Koob GF (1998). Drug dependence: stress and dysregulation of brain reward pathways. Drug Alcohol Depend 51: 23-47.
52. Kuikka JT, Repo E, Bergstrom KA, Tupala E, Tiihonen J (2000). Specific binding and laterality of human extrastriatal dopamine D2/D3 receptors in late onset type 1 alcoholic patients. Neurosci Lett 292: 57-59.
53. Lammertsma AA, Hume SP (1996). Simplified reference tissue model for PET receptor studies. Neuroimage 4: 153-158.
54. Laruelle M, Abi-Dargham A, van Dyck CH, Rosenblatt W, Zea-Ponce Y, Zoghbi SS et al (1995). SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med 36: 1182-1190.
55. Le AD, Quan B, Juzytch W, Fletcher PJ, Joharchi N, Shaham Y (1998). Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats. Psychopharmacology (Berl) 135: 169-174.
56. Leyton M, Boileau I, Benkelfat C, Diksic M, Baker G, Dagher A (2002). Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C] raclopride study in healthy men. Neuropsychopharmacology 27: 1027-1035.
57. Liu X, Weiss F (2002). Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats. J Pharmacol Exp Ther 300: 882-889.
58. Madrid GA, MacMurray J, Lee JW, Anderson BA, Comings DE (2001). Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholism. Alcohol 23: 117-122.
59. Marinelli M, Piazza PV (2002). Interaction between glucocorticoid hormones, stress and psychostimulant drugs. Eur J Neurosci 16: 387-394.
60. Martinez D, Slifstein M, Broft A, Mawlawi O, Hwang DR, Huang Y et al (2003). Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum. J Cereb Blood Flow Metab 23: 285-300.
61. Mendelson JH, Mello NK, Sholar MB, Siegel AJ, Mutschler N, Halpern J (2002). Temporal concordance of cocaine effects on mood states and neuroendocrine hormones. Psychoneuroendocrinology 27: 71-82.
62. Ohannessian CM, Hesselbrock VM, Tennen H, Affleck G (1994). Hassles and uplifts and generalized outcome expectancies as moderators on the relation between a family history of alcoholism and drinking behaviors. J Stud Alcohol 55: 754-763.
63. Ortiz J, Fitzgerald LW, Lane S, Terwilliger R, Nestler EJ (1996). Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress. Neuropsychopharmacology 14: 443-452.
64. Phillips TJ, Brown KJ, Burkhart-Kasch S, Wenger CD, Kelly MA, Rubinstein M et al (1998). Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nat Neurosci 1: 610-615.
65. Piazza PV, Le Moal M (1997). Glucocorticoids as a biological substrate of reward: physiological and pathophysiological implications. Brain Res Brain Res Rev 25: 359-372.
66. Piazza PV, Le Moal M (1998). The role of stress in drug self-administration. Trends Pharmacol Sci 19: 67-74.
67. Piazza PV, Maccari S, Deminiere JM, Le Moal M, Mormede P, Simon H (1991). Corticosterone levels determine individual vulnerability to amphetamine self-administration. Proc Natl Acad Sci USA 88: 2088-2092.
68. Piazza PV, Rouge-Pont F, Deroche V, Maccari S, Simon H, Le Moal M (1996). Glucocorticoids have state-dependent stimulant effects on the mesencephalic dopaminergic transmission. Proc Natl Acad Sci USA 93: 8716-8720.
69. Pruessner JC, Champagne F, Meaney MJ, Dagher A (2004). Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride. J Neurosci 24: 2825-2831.
70. Rouge-Pont F, Piazza PV, Kharouby M, Le Moal M, Simon H (1993). Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration. A microdialysis study. Brain Res 602: 169-174.
71. Saal D, Dong Y, Bonci A, Malenka RC (2003). Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37: 577-582.
72. Samson HH, Hodge CW (1993). The role of the mesoaccumbens dopamine system in ethanol reinforcement: studies using the techniques of microinjection and voltammetry. Alcohol Alcohol Suppl 2: 469-474.
73. Sarnyai Z, Shaham Y, Heinrichs SC (2001). The role of corticotropin-releasing factor in drug addiction. Pharmacol Rev 53: 209-243.
74. Schad CA, Justice Jr JB, Holtzman SG (2002). Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions. J Pharmacol Exp Ther 300: 932-938.
75. Schlaepfer TE, Pearlson GD, Wong DF, Marenco S, Dannals RF (1997). PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects. Am J Psychiatry 154: 1209-1213.
76. Schmitz Y, Lee CJ, Schmauss C, Gonon F, Sulzer D (2001). Amphetamine distorts stimulation-dependent dopamine overflow: effects on D2 autoreceptors, transporters, and synaptic vesicle stores. J Neurosci 21: 5916-5924.
77. Schuckit MA, Tsuang JW, Anthenelli RM, Tipp JE, Nurnberger Jr JI (1996). Alcohol challenges in young men from alcoholic pedigrees and control families: a report from the COGA project. J Stud Alcohol 57: 368-377.
78. Shaham Y, Erb S, Stewart J (2000). Stress-induced relapse to heroin and cocaine seeking in rats: a review. Brain Res Brain Res Rev 33: 13-33.
79. Sinha R, Catapano D, O'Malley S (1999). Stress-induced craving and stress response in cocaine dependent individuals. Psychopharmacology (Berl) 142: 343-351.
80. Sinha R, Fuse T, Aubin LR, O'Malley SS (2000). Psychological stress, drug-related cues and cocaine craving. Psychopharmacology (Berl) 152: 140-148.
81. Sinha R, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ (2003). Hypothalamic-pituitary-adrenal axis and sympathoadreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology (Berl) 170: 62-72.
82. Smith SM, Vaughan JM, Donaldson CJ, Rivier J, Li C, Chen A et al (2004). Cocaine- and amphetamine-regulated transcript activates the hypothalamic- pituitary-adrenal axis through a corticotropin-releasing factor receptor-dependent mechanism. Endocrinology 145: 5202-5209.
83. Soderpalm AH, de Wit H (2002). Effects of stress and alcohol on subjective state in humans. Alcohol Clin Exp Res 26: 818-826.
84. Sorg BA (1992). Mesocorticolimbic dopamine systems: cross-sensitization between stress and cocaine. Ann NY Acad Sci 654: 136-144.
85. Spanagel R, Weiss F (1999). The dopamine hypothesis of reward: past and current status. Trends Neurosci 22: 521-527.
86. Sussman S, Dent CW (2000). One-year prospective prediction of drug use from stress-related variables. Subst Use Misuse 35: 717-735.
87. Swerdlow NR, Koob GF, Cador M, Lorang M, Hauger RL (1993). Pituitary-adrenal axis responses to acute amphetamine in the rat. Pharmacol Biochem Behav 45: 629-637.
88. Tidey JW, Miczek KA (1996). Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study. Brain Res 721: 140-149.
89. Tiihonen J, Kuikka J, Hakola P, Paanila J, Airaksinen J, Kronen M et al (1994). Acute ethanol-induced changes in cerebral blood flow. Am J Psychiatry 151: 1505-1508.
90. Tiihonen J, Vilkman H, Rasanen P, Ryynanen OP, Hakko H, Bergman J et al (1998). Striatal presynaptic dopamine function in type 1 alcoholics measured with positron emission tomography. Mol Psychiatry 3: 156-161.
91. van Dyck CH, Seibyl JP, Malison RT, Lamelle M, Zoghbi SS, Baldwin RM et al (2002). Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries. Am J Geriatr Psychiatry 10: 36-43.
92. Volkow ND, Wang GJ, Fowler JS, Logan J, Franceschi D, Maynard L et al (2002a). Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications. Synapse 43: 181-187.
93. Vollcow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, Wong C et al (1999). Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors. J Pharmacol Exp Ther 291: 409-415.
94. Volkow ND, Wang GJ, Fowler JS, Logan J, Schlyer D, Hitzemann R et al (1994). Imaging endogenous dopamine competition with [C-11] Raclopride in the human brain. Synapse 16: 255-262.
95. Volkow ND, Wang GJ, Fowler JS, Thanos PP, Logan J, Gatley SJ et al (2002b). Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study. Synapse 46: 79-82.
96. Volkow ND, Wang GJ, Ma Y, Fowler JS, Zhu W, Maynard L et al (2003). Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. J Neurosci 23: 11461-11468.
97. Wachtel SR, Charnot A, de Wit H (2001). Acute hydrocortisone administration does not affect subjective responses to d-amphetamine in humans. Psychopharmacology (Berl) 153: 380-388.
98. Waltman C, McCaul ME, Wand GS (1994). Adrenocorticotropin responses following administration of ethanol and ovine corticotropin-releasing hormone in the sons of alcoholics and control subjects. Alcohol Clin Exp Res 18: 826-830.
99. Wang GJ, Volkow ND, Franceschi D, Fowler JS, Thanos PK, Scherbaum N et al (2000). Regional brain metabolism during alcohol intoxication. Alcohol Clin Exp Res 24: 822-829.
100. Wand G, McCaul ME, Gotjen D, Reynolds J, Lee S (2001). Confirmation that offspring from families with alcohol-dependent individuals have greater hypothalamic-pituitary-adrenal axis activation induced by naloxone compared with offspring without a family history of alcohol dependence. Alcohol Clin Exp Res 25: 1134-1139.
101. Wand GS, Mangold D, Ali M (1999a). Adrenocorticotropin responses to naloxone in sons of alcohol-dependent men. J Clin Endocrinol Metab 84: 64-68.
102. Wand GS, Mangold D, Ali M, Giggey P (1999b). Adrenocortical responses and family history of alcoholism. Alcohol Clin Exp Res 23: 1185-1190.
103. Wand GS, Mangold D, El Deiry S, McCaul ME, Hoover D (1998). Family history of alcoholism and hypothalamic opioidergic activity. Arch Gen Psychiatry 55: 1114-1119.
104. Ward AS, Collins ED, Haney M, Foltin RW, Fischman MW (1998). Ketoconazole attenuates the cortisol response but not the subjective effects of smoked cocaine in humans. Behav Pharmacol 9: 577-586.
105. Ward AS, Collins ED, Haney M, Foltin RW, Fischman MW (1999). Blockade of cocaine-induced increases in adrenocorticotrophic hormone and cortisol does not attenuate the subjective effects of smoked cocaine in humans. Behav Pharmacol 10: 523-529.
106. Wendt PE, Risberg J, Stenberg G, Rosen I, Ingvar DH (1994). Ethanol reduces asymmetry of visual Rcbf responses. J Cereb Blood Flow Metab 14: 963-973.
107. Wise RA (1998). Drug-activation of brain reward pathways. Drug Alcohol Depend 51: 13-22.
108. Wong DF (2002). In vivo imaging of D2 dopamine receptors in schizophrenia: the ups and downs of neuroimaging research. Arch Gen Psychiatry 59: 31-34.
109. Yavich L, Tiihonen J (2000). Ethanol modulates evoked dopamine release in mouse nucleus accumbens: dependence on social stress and dose. Eur J Pharmacol 401: 365-373.
110. Zhou Y, Endres CJ, Brasic JR, Huang SC, Wong DF (2003). Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue model. Neuroimage 18: 975-989.