The dopamine-containing neuron: Maestro or simple musician in the orchestra of addiction?

Trends in Pharmacological Sciences

Volumn 24, Issue 4, 2003, Pages 172-177

  Bonci, Antonello ^a   Bernardi, Giorgio ^b,d   Grillner, Pernilla ^c   Mercuri, Nicola B ^b,d  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c KAROLINSKA INSTITUTE   (Sweden)

^d IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; AMPHETAMINE; COCAINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; MECAMYLAMINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINE; OPIATE; PSYCHOSTIMULANT AGENT; SEROTONIN;

4 AMINOBUTYRIC ACID RELEASE; ADDICTION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CENTRAL NERVOUS SYSTEM DEPRESSION; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; EXTRACELLULAR SPACE; INHIBITORY POSTSYNAPTIC POTENTIAL; LIMBIC CORTEX; LONG TERM POTENTIATION; MESENCEPHALON; NEUROTRANSMISSION; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SEROTONIN BRAIN LEVEL; SEROTONIN RELEASE; TEGMENTUM;

EID: 0037388119     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(03)00068-3     Document Type: Review

References (49)

1. DiChiara G., Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl. Acad. Sci. U. S. A. 85:1988;5274-5278.
2. Koob G.F., Nestler E.J. The neurobiology of drug addiction. J. Neuropsychiatry Clin. Neurosci. 9:1997;482-497.
3. Spanagel R., Weiss F. The dopamine hypothesis of reward: past and current status. Trends Neurosci. 22:1999;521-527.
4. Volkow N.D., et al. Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D2 receptors. J. Pharmacol. Exp. Ther. 291:1999;409-415.
5. Ranaldi R., Wise R.A. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. J. Neurosci. 21:2001;5841-5846.
6. Berridge K.C., Robinson T.E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res. Rev. 28:1998;309-369.
7. Schultz W. Multiple reward signals in the brain. Nat. Rev. Neurosci. 1:2000;199-207.
8. Overton P.G., Clark D. Burst firing in midbrain dopaminergic neurons. Brain Res. Brain Res. Rev. 25:1997;312-334.
9. Kitai S.T., et al. Afferent modulation of dopamine neuron firing patterns. Curr. Opin. Neurobiol. 9:1999;690-697.
10. Gonon F.G. Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry. Neuroscience. 24:1988;19-28.
11. Grace A.A. The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction. 95:2000;S119-S128.
12. Marinelli M., White F.J. Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. J. Neurosci. 20:2000;8876-8885.
13. Mercuri N.B., et al. The electrophysiological actions of dopamine and dopaminergic drugs on neurons of the substantia nigra pars compacta and ventral tegmental area. Life Sci. 51:1992;711-718.
14. Jones S., Kauer J.A. Amphetamine depresses excitatory synaptic transmission via serotonin receptors in the ventral tegmental area. J. Neurosci. 19:1999;9780-9787.
15. Trent F., et al. Amphetamine exerts anomalous effects on dopaminergic neurons in neonatal rats in vivo. Eur. J. Pharmacol. 204:1991;265-272.
16. Shi W.X., et al. Dual effects of d-amphetamine on dopamine neurons mediated by dopamine and nondopamine receptors. J. Neurosci. 20:2000;3504-3511.
17. Paladini C.A., et al. Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons. Nat. Neurosci. 4:2001;275-281.
18. Cameron D.L., Williams J.T. Cocaine inhibits GABA release in the VTA through endogenous 5-HT. J. Neurosci. 14:1994;6763-6767.
19. Ingram S.L., et al. Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons. Nat. Neurosci. 5:2002;971-978.
20. Bonci A., Malenka R.C. Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area. J. Neurosci. 19:1999;3723-3737.
21. Overton P.G., et al. Long-term potentiation at excitatory amino acid synapses on midbrain dopamine neurons. NeuroReport. 10:1999;221-226.
22. Thomas M.J., et al. Modulation of long-term depression by dopamine in the mesolimbic system. J. Neurosci. 20:2000;5581-5586.
23. Ungless M.A., et al. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature. 411:2001;583-587.
24. Saal D., et al. Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron. 37:2003;577-582.
25. Jones S., et al. Amphetamine blocks long-term synaptic depression in the ventral tegmental area. J. Neurosci. 20:2000;5575-5580.
26. Garris P.A., et al. Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain. J. Neurosci. 14:1994;6084-6093.
27. Cooper D.C. The significance of action potential bursting in the brain reward circuit. Neurochem. Int. 41:2002;333-340.
28. Hyman S.E., Malenka R.C. Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci. 2:2001;695-703.
29. Wolf M.E. The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog. Neurobiol. 54:1998;679-720.
30. Jones S., Gutlerrner J.L. Addictive drugs modify excitatory synaptic control of midbrain dopamine cells. NeuroReport. 13:2002;29-33.
31. Johnson S.W., North R.A. Opioids excite dopamine neurons by hyperpolarization of local interneurons. J. Neurosci. 12:1992;483-488.
32. Manzoni O.J., Williams J.T. Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal. J. Neurosci. 19:1999;6629-6636.
33. Bals-Kubik R., et al. Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. J. Pharmacol. Exp. Ther. 264:1993;489-495.
34. Wise R.A. Brain reward circuitry: insights from unsensed incentives. Neuron. 36:2002;229-240.
35. Mereu G., et al. Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Eur. J. Pharmacol. 141:1987;395-399.
36. Nisell M., et al. Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area. Synapse. 16:1994;36-44.
37. Schilström B., et al. N-Methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience. 82:1998;781-789.
38. Pidoplichko V.I., et al. Nicotine activates and desensitizes midbrain dopamine neurons. Nature. 390:1997;401-404.
39. McGehee D.S., et al. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science. 269:1995;1692-1696.
40. Mansvelder H.D., et al. Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron. 33:2002;905-919.
41. Mansvelder H.D., McGehee D.S. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. 27:2000;349-357.
42. Dani J.A., et al. Synaptic plasticity and nicotine addiction. Neuron. 31:2001;349-352.
43. Mansvelder H.D., McGehee D.S. Cellular and synaptic mechanisms of nicotine addiction. J. Neurobiol. 53:2002;606-617.
44. Schultz W. Getting formal with dopamine and reward. Neuron. 36:2002;241-263.
45. Carlezon W.A. Jr, Nestler E.J. Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci. 25:2002;610-615.
46. Berke J.D., Hyman S.E. Addiction, dopamine, and the molecular mechanisms of memory. Neuron. 25:2000;515-532.
47. Wolf M.E. The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog. Neurobiol. 54:1998;679-720.
48. Koob G.F., Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology. 24:2001;97-129.
49. Everitt B.J., Wolf M.E. Psychomotor stimulant addiction: a neural systems perspective. J. Neurosci. 22:2002;3312-3320.