Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export

EMBO Journal

Volumn 24, Issue 4, 2005, Pages 813-823

  Vinciguerra, Patrizia ^a   Iglesias, Nahid ^a   Camblong, Jurgi ^a   Zenklusen, Daniel ^a   Stutz, Françoise ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Mlp proteins; mRNP biogenesis and export; Nab2p; Transcription; Yra1p

Indexed keywords

ADAPTOR PROTEIN; BETA GALACTOSIDASE; MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN MLP; UNCLASSIFIED DRUG;

ARTICLE; CYTOPLASM; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE MUTATION; GENOME ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; RNA EXTRACTION; RNA TRANSCRIPTION; WESTERN BLOTTING;

BETA-GALACTOSIDASE; DOWN-REGULATION; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; IN SITU HYBRIDIZATION; LAC OPERON; MUTATION; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN BINDING; RIBONUCLEOPROTEINS; RNA STABILITY; RNA TRANSPORT; RNA, FUNGAL; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TEMPERATURE; TRANSCRIPTION, GENETIC;

EID: 15444368318     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600527     Document Type: Article

References (37)

1. Bangs P, Burke B, Powers C, Craig R, Purohit A, Doxsey S (1998) Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export. J Cell Biol 143: 1801-1812
2. Bousquet-Antonelli C, Presutti C, Tollervey D (2000) Identification of a regulated pathway for nuclear pre-mRNA turnover. Cell 102: 765-775
3. Burkard KT, Butler JS (2000) A nuclear 3′-5′ exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein NpBp. Mol Cell Biol 20: 604-616
4. Casolari JM, Brown CR, Komili S, West J, Hieronymus H, Silver PA (2004) Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell 117: 427-439
5. Chavez S, Beilharz T, Rondon AG, Erdjument-Bromage H, Tempst P, Svejstrup JQ, Lithgow T, Aguilera A (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19: 5824-5834
6. Cordes VC, Hase ME, Muller L (1998) Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex. Exp Cell Res 245: 43-56
7. Cordes VC, Reidenbach S, Rackwitz HR, Franke WW (1997) Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. J Cell Biol 136: 515-529
8. Feuerbach F, Galy V, Trelles-Sticken E, Fromont-Racine M, Jacquier A, Gilson E, Olivo-Marin JC, Scherthan H, Nehrbass U (2002) Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat Cell Biol 4: 214-221
9. Galy V, Gadal O, Fromont-Racine M, Romano A, Jacquier A, Nehrbass U (2004) Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Cell 116: 63-73
10. Galy V, Olivo-Marin JC, Scherthan H, Doye V, Rascalou N, Nehrbass U (2000) Nuclear pore complexes in the organization of silent telomeric chromatin. Nature 403: 108-112
11. Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Hofert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415: 141-147
12. Gilbert W, Guthrie C (2004) The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. Mol Cell 13: 201-212
13. Green DM, Johnson CP, Hagan H, Corbett AH (2003) The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export. Proc Natl Acad Sci USA 100: 1010-1015
14. Hector RE, Nykamp KR, Dheur S, Anderson JT, Non PJ, Urbinati CR, Wilson SM, Minvielle-Sebastia L, Swanson MS (2002) Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export. EMBO J 21: 1800-1810
15. Hediger F, Dubrana K, Gasser SM (2002) Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control. J Struct Biol 140: 79-91
16. Hilleren P, McCarthy T, Rosbash M, Parker R, Jensen TH (2001) Quality control of mRNA 3′-end processing is linked to the nuclear exosome. Nature 413: 538-542
17. Huertas P, Aguilera A (2003) Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol Cell 12: 711-721
18. Ishii K, Arib G, Lin C, Van Houwe G, Laemmli UK (2002) Chromatin boundaries in budding yeast: the nuclear pore connection. Cell 109: 551-562
19. Jensen TH, Boulay J, Rosbash M, Libri D (2001) The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr Biol 11: 1711-1715
20. Jensen TH, Boulay J, Olesen JR, Colin J, Weyler M, Libri D (2004) Modulation of transcription affects mRNP quality. Mol Cell 16: 235-244
21. Jimeno S, Rondon AG, Luna R, Aguilera A (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 21: 3526-3535
22. Kosova B, Pante N, Rollenhagen C, Podtelejnikov A, Mann M, Aebi U, Hurt E (2000) Mlp2p, a component of nuclear pore attached intranuclear filaments, associates with nic96p. J Biol Chem 275: 343-350
23. Legrain P, Rosbash M (1989) Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm. Cell 57: 573-583
24. Lei EP, Krebber H, Silver PA (2001) Messenger RNAs are recruited for nuclear export during transcription. Genes Dev 15: 1771-1782
25. Libri D, Dower K, Boulay J, Thomsen R, Rosbash M, Jensen TH (2002) Interactions between mRNA export commitment, 3′-end quality control, and nuclear degradation. Mol Cell Biol 22: 8254-8266
26. Long RM, Elliott DJ, Stutz F, Rosbash M, Singer RH (1995) Spatial consequences of defective processing of specific yeast mRNAs revealed by fluorescent in situ hybridization. RNA 1: 1071-1078
27. Marfatia KA, Crafton EB, Green DM, Corbett AH (2003) Domain analysis of the Saccharomyces cerevisiae heterogeneous nuclear ribonucleoprotein, Nab2p. Dissecting the requirements for Nab2p-facilitated poly(A) RNA export. J Biol Chem 278: 6731-6740
28. Rodriguez-Navarro S, Fischer T, Luo MJ, Antunez O, Perez-Ortin JE, Reed R, Hurt E (2004) Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell 116: 75-86
29. Strambio-de-Castillia C, Blobel G, Rout MP (1999) Proteins connecting the nuclear pore complex with the nuclear interior. J Cell Biol 144: 839-855
30. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417: 304-308
31. Stutz F, Izaurralde E (2003) The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol 13: 319-327
32. Thomsen R, Libri D, Boulay J, Rosbash M, Jensen TH (2003) Localization of nuclear retained mRNAs in Saccharomyces cerevisiae. RNA 9: 1049-1057
33. Torchet C, Bousquet-Antonelli C, Milligan L, Thompson E, Kufel J, Tollervey D (2002) Processing of 3′-extended read-through transcripts by the exosome can generate functional mRNAs. Mol Cell 9: 1285-1296
34. Vinciguerra P, Stutz F (2004) mRNA export: an assembly line from genes to nuclear pores. Curr Opin Cell Biol 16: 285-292
35. Zenklusen D, Vinciguerra P, Strahm Y, Stutz F (2001) The yeast hnRNP-like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p. Mol Cell Biol 21: 4219-4232
36. Zenklusen D, Vinciguerra P, Wyss JC, Stutz F (2002) Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol 22: 8241-8253
37. Zimowska G, Aris JP, Paddy MR (1997) A Drosophila Tpr protein homolog is localized both in the extrachromosomal channel network and to nuclear pore complexes. J Cell Sci 110 (Part 8): 927-944