Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments

Journal of Cell Biology

Volumn 136, Issue 3, 1997, Pages 515-529

  Cordes, Volker C ^a   Reidenbach, Sonja ^a   Rackwitz, Hans Richard ^a   Franke, Werner W ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY;

AMPHIBIA; ANIMAL CELL; ARTICLE; ELECTRON MICROSCOPY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MAMMAL; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA TRANSLATION; XENOPUS LAEVIS;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CACO-2 CELLS; CATTLE; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DOGS; EPITOPES; HELA CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR ENVELOPE; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; SWINE; TUMOR CELLS, CULTURED; XENOPUS LAEVIS;

AMPHIBIA; ANIMALIA; MAMMALIA; VERTEBRATA; XENOPUS LAEVIS;

EID: 0031043895     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.136.3.515     Document Type: Article

References (70)

1. Akey, C.W., and M. Rademacher. 1993. Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy. J. Cell Biol. 122:1-20.
2. Bangs, P.L., C.A. Sparks, P.R. Odgren, and E.G. Fey. 1996. Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex. J. Cell. Biochem. 61:48-60.
3. Bastos, R., N. Pante, and B. Burke. 1995. Nuclear pore complex proteins. Int. Rev. Cytol. 1626:257-302.
4. Blobel, G. 1985. Gene gating: a hypothesis. Proc. Natl. Acad. Sci. USA. 82: 8527-8529.
5. Bohmann, K., J. Ferreira, N. Santama, K. Weis, and A.I. Lamond. 1995. Molecular analysis of the coiled body. J. Cell Sci. Suppl. 19:107-113.
6. Byrd, D.A., D.J. Sweet, N. Pante, K.M. Konstantinov, T. Guan, A.C.S. Saphire, P.J. Mitchell, C.S. Cooper, U. Aebi, and L. Gerace. 1994. Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J. Cell Biol. 127:1515-1526.
7. Chardonnet, Y., and S. Dales. 1972. Early events in the interaction of Adenovirus with HeLa cells. III. Relationship between an ATPase activity in nuclear envelopes and transfer of core material: a hypothesis. Virology. 48:342-350.
8. Cordes, V.C., S. Reidenbach, A. Köhler, N. Stuurman, R. van Driel, and W.W. Franke. 1993. Intranuclear filaments containing a nuclear pore complex protein. J. Cell Biol. 123:1333-1344.
9. Cordes, V.C., S. Reidenbach, and W.W. Franke. 1995. High content of a nuclear pore protein in cytoplasmic annulate lamellae of Xenopus oocytes. Eur. J. Cell Biol. 68:240-255.
10. Cordes, V.C., S. Reidenbach, and W.W. Franke. 1996. Cytoplasmic annulate lamellae in cultured cells: composition, distribution, and mitotic behavior. Cell Tissue Res. 283:177-191.
11. Davis, L.I. 1995. The nuclear pore complex. Annu. Rev. Biochem. 64:865-896.
12. Davis, L.I., and G. Blobel. 1986. Identification and characterization of a nuclear pore complex protein. Cell. 45:699-709.
13. Emini, E.A., J.V. Hughes, D.S. Perlow, and J. Boger. 1985. Induction of hepatitis A virus-neutralizing antibody by a virus-specific peptide. J. Virol. 55:836-839.
14. Feldherr, C.M. 1974. The binding characteristics of the nuclear annuli. Exp. Cell Res. 85:271-277.
15. Franke, W.W. 1966. Isolated nuclear membranes. J. Cell Biol. 31:619-623.
16. Franke, W.W. 1970. On the universality of nuclear pore complex structure. Z. Zellforsch. 105:405-129.
17. Franke, W.W. 1974. Structure, biochemistry, and functions of the nuclear envelope. Int. Rev. Cytol. 4:72-237.
18. Franke, W.W., and U. Scheer. 1970a. The ultrastructure of the nuclear envelope of amphibian oocytes: a reinvestigation. I. The mature oocyte. J. Ultrastruct. Res. 30:288-316.
19. Franke, W.W., and U. Scheer. 1970b. The ultrastructure of the nuclear lope of amphibian oocytes: a reinvestigation. II. The immature oocyte and dynamic aspects. J. Ultrastruct. Res. 30:317-327.
20. Gall, J.G. 1967. Octagonal nuclear pores. J. Cell Biol. 32:391-399.
21. Gall, J.G., A. Tsvetkov, Z. Wu, and C. Murphy. 1995. Is the sphere organelle coiled body a universal nuclear component? Dev. Genet. 16:25-35.
22. Gerace, L., Y. Ottaviano, and C. Kondor-Koch. 1982. Identification of a major polypeptide of the nuclear pore complex. J. Cell Biol. 95:826-837.
23. Goldberg, M.W., and T.D. Allen. 1992. High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores. J. Cell Biol. 119:1429-1440.
24. Goldberg, M.W., and T.D. Allen. 1995. Structural and functional organization of the nuclear envelope. Curr. Opin. Cell Biol. 7:301-309.
25. Greco, A., M.A. Pierotti, I. Bongarzone, S. Pagliardini, C. Lanzi, and G. Della Porta. 1992. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene. 7:237-242.
26. Hallberg, E., R.W. Wozniak, and G. Blobel. 1993. An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region. J. Cell Biol. 122:513-521.
27. Hinshaw, I.E., B.O. Carragher, and R.A. Milligan. 1992. Architecture and design of the nuclear pore complex. Cell. 69:1133-1141.
28. Höger, T.H., C. Grund, W.W. Franke, and G. Krohne. 1991. Immunolocalization of lamins in the thick nuclear lamina of human synovial cells. Eur. J. Cell Biol. 54:150-156.
29. Jarnik, M., and U. Aebi. 1991. Towards a more complete 3-D structure of the nuclear pore complex. J. Struct. Biol. 107:291-308.
30. Jameson, B.A., and H. Wolf. 1988. The antigenic index: a novel algorithm for predicting antigenic determinants. Comput. Appl. Biosci. 4:181-186.
31. Kartenbeck, J., H. Zentgraf, U. Scheer, and W.W. Franke. 1971. The nuclear envelope in freeze-etching. Adv. Anat. Embryol. Cell Biol. 45:1-55.
32. Kraemer, D., R.W. Wozniak, G. Blobel, and A. Radu. 1994. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. Proc. Natl. Acad. Sci. USA. 91:1519-1523.
33. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
34. Leube, R.E., U. Leimer, C. Grund, W.W. Franke, N. Harth, and B. Wiedenmann. 1994. Sorting of synaptophysin into special vesicles in nonneuroendocrine epithelial cells. J. Cell Biol. 127:1589-1601.
35. Meier, U.T., and G. Blobel. 1992. Nopp140 shuttles on tracks between nucleolus and cytoplasm. Cell. 70:127-138.
36. Melchior, F., and L. Gerace. 1995. Mechanism of nuclear protein import. Curr. Opin. Cell Biol. 7:310-318.
37. Melchior, F., T. Guan, N. Yokoyama, T. Nishimoto, and L. Gerace. 1995. GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import. J. Cell Biol. 131:571-581.
38. Mitchell, P.J., and C.S. Cooper. 1992a. Nucleotide sequence analysis of human tpr cDNA clones. Oncogene. 7:383-388.
39. Mitchell, P.J., and C.S. Cooper. 1992b. The human tpr gene encodes a protein of 2094 amino acids that has extensive coiled-coil regions and an acidic C-terminal domain. Oncogene. 7:2329-2333.
40. Newmeyer, D.D., and D.J. Forbes. 1988. Nuclear import can be separated into distinct steps in vitro: nuclear binding and translocation. Cell. 52:641-653.
41. Niehrs, C., W.B. Huttner, and U Rüther. 1992. In vivo expression and stoichiometric sulfation of the artificial protein sulfophilin, a polymer of tyrosine sulfation sites. J. Biol. Chem. 267:15938-15942.
42. O'Farrell, P.H. 1975. High resolution two-dimensional electrophoresis. J. Biol. Chem. 250:4007-4021.
43. Pante, N., and U. Aebi. 1995a. Exploring nuclear pore complex structure and function in molecular detail. J. Cell Sci. Suppl. 19:1-11.
44. Pante, N., and U. Aebi. 1995b. Toward a molecular understanding of the structure and function of the nuclear pore complex. Int. Rev. Cytol. 162B:225-255.
45. Pante, N., and U. Aebi. 1996. Toward the molecular dissection of protein import into nuclei. Curr. Opin. Cell Biol. 8:397-406.
46. Pante, N., R. Bastos, B. McMorrow, B. Burke, and U. Aebi. 1994. Interaction and three-dimensional localization of a group of nuclear pore complex proteins. J. Cell Biol. 126:603-617.
47. Park, M., M. Dean, C.S. Cooper, M. Schmidt, S.J. O'Brien, D.G. Blair, and G.F. Vande Woude. 1986. Mechanism of met oncogene activation. Cell. 45:895-904.
48. Powers, M.A., C. Macaulay, F.R. Masiarz, and D.J. Forbes. 1995. Reconstituted nuclei depleted of a novel vertebrate GLFG nuclear pore protein, p97, import but are defective in nuclear growth and replication. J. Cell Biol. 128:1-9.
49. Radu, A., M.S. Moore, and G. Blobel. 1995. The peptide repeat domain of nucleoporin nup98 functions as a docking site in transport across the nuclear pore complex. Cell. 81:215-222.
50. Reichelt, R., A. Holzenburg, E.L. Buhle, M. Jarnik, A. Engel, and U. Aebi. 1990. Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore components. J. Cell Biol. 110:883-894.
51. Richardson, W.D., A.D. Mills, S.M. Dilworth, R.A. Laskey, and C. Dingwall. 1988. Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through the nuclear pores. Cell. 52:655-664.
52. Ris, H. 1989. Three-dimensional imaging of cell ultrastructure with high resolution low voltage SEM. Inst. Phys. Conf. Ser. 98:657-662.
53. Ris, H. 1991. The three dimensional structure of the nuclear pore complex as seen by high voltage electron microscopy and high resolution low voltage scanning electron microscopy. EMSA Bull. 21:54-56.
54. Ris, H., and M. Malecki. 1993. High-resolution field emission scanning electron microscope imaging of internal cell structures after epon extraction from sections: a new approach to correlative ultrastructural and immunocytochemical studies. J. Struct. Biol. 111:148-157.
55. Roth, M.B. Spheres, coiled bodies, and nuclear bodies. Curr. Opin. Cell Biol. 7: 325-328.
56. Rout, M.P., and S.R. Wente. 1994. Pores for thought: nuclear pore complex proteins. Trends Cell Biol. 4:357-365.
57. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:5463-5467.
58. Schnölzer, M., P. Alewood, A. Jones, D. Alewood, and S.B.H. Kent. 1992. In situ neutralization in Boc-chemistry solid phase peptide synthesis. Int. J. Peptide Protein Res. 40:180-193.
59. Simos, G., and E.G. Hurt. 1995. Nucleocytoplasmic transport: factors and mechanisms. FEBS Lett. 369:107-112.
60. Soman, N.R., P. Correa, B.A. Ruiz, and G.N. Wogan. 1991. The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. Proc. Natl. Acad. Sci. USA. 88:4892-4896.
61. Strouboulis, J., and A.P. Wolffe. 1996. Functional compartmentalization of the nucleus. J. Cell Sci. 109:1991-2000.
62. Sukegawa, J., and G. Blobel. 1993. A nuclear pore complex protein that contains zinc finger binding motifs, binds DNA, and faces the nucleoplasm. Cell. 72:29-38.
63. Summers, M.D. 1971. Electron microscopic observations on granulosis virus entry, uncoating and replication processes during infection of the midgut cells of Trichoplusia ni. J. Ultrastruct. Res. 35:606-625.
64. Sweet, D.J., and L. Gerace. 1995. Taking from the cytoplasm and giving to the pore: soluble transport factors in nuclear protein import. Trends Cell Biol. 5: 444-447.
65. Thomas, J.O., and R.D. Kornberg. 1975. An octamer of histones in chromatin and free in solution. Proc. Natl. Acad. Sci. USA. 72:2626-2630.
66. Venetianer, A., D.L. Schiller, T. Magin, and W.W. Franke. 1983. Cessation of cytokeratin expression in a rat hepatoma cell line lacking differentiated functions. Nature (Lond.). 305:730-733.
67. Wilken, N., J.-L. Senecal, U. Scheer, and M.-C. Dabauvalle. 1995. Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex. Eur. J. Cell Biol. 68:211-219.
68. Wozniak, R.W., E. Bartnik, and G. Blobel. 1989. Primary structure analysis of an integral membrane glycoprotein of the nuclear pore. J. Cell Biol. 108: 2083-2092.
69. Wu, J., M.J. Matunis, D. Kraemer, G. Blobel, and E. Coutavas. 1995. Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J. Biol. Chem. 270:14209-14213.
70. Yokoyama, N., N. Hayashi, T. Seki, N. Pante, T. Ohba, K. Nishil, K. Kuma, T. Hayashida, T. Miyata, U. Aebi et al. 1995. A giant nucleopore protein that binds Ran/TC4. Nature (Lond.). 376:184-188.