Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naïve and pre-immunized mice

Gene Therapy

Volumn 12, Issue 5, 2005, Pages 427-436

  Varnavski, A N ^a,b,c   Calcedo, R ^a,b   Bove, M ^a,b   Gao, G ^a,b   Wilson, J M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c Antigenics Inc   (United States)

Author keywords

Adenovirus; Innate immunity

Indexed keywords

ADENOVIRUS VECTOR; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROID CELL; FEMALE; HEMATOPOIETIC STEM CELL; IMMUNE RESPONSE; IMMUNITY; IN VIVO STUDY; LEUKOPENIA; MITOSIS INHIBITION; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEROTYPE; THROMBOCYTOPENIA; TOXICITY TESTING; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINATION;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANIMALS; BONE MARROW; CYTOKINES; FEMALE; GENE THERAPY; GENETIC VECTORS; HUMANS; IMMUNITY; IMMUNOGLOBULIN G; LEUKOPENIA; LIVER; MICE; MICE, INBRED C57BL; THROMBOCYTOPENIA; TRANSAMINASES;

ADENOVIRIDAE; ANIMALIA; MACACA MULATTA;

EID: 15444366434     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302347     Document Type: Article

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