Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries: Potential for immunosuppression and vector engineering to overcome barriers of immunity

Journal of Clinical Investigation

Volumn 99, Issue 2, 1997, Pages 209-219

  Schulick, Andrew H ^a   Vassalli, Giuseppe ^b,c   Dunn, Peter F ^a   Dong, Gang ^a   Rade, Jeffrey J ^a   Zamarron, Concepcion ^b   Dichek, David A ^a,b,c  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

adenovirus; arteries; gene transfer; immunity; rats

Indexed keywords

CYCLOSPORIN A; LYMPHOCYTE ANTIBODY; NEUTRALIZING ANTIBODY; PLASMID DNA; THYMOCYTE ANTIBODY; VIRUS ANTIBODY; VIRUS VACCINE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CAROTID ARTERY; CELL INFILTRATION; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; HISTOCHEMISTRY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY INFILTRATE; INTRAARTERIAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECOMBINANT GENE;

EID: 0031020458     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119149     Document Type: Article

References (48)

1. Nabel, E.G., and G.J. Nabel. 1994. Complex models for the study of gene function in cardiovascular biology. Annu. Rev. Physiol. 56:741-761.
2. Rade, J.J., A.H. Schulick, R. Virmani, and D.A. Dichek. 1996. Local adenoviral-mediated expression of recombinant hirudin reduces neointimal formation after arterial injury. Nat. Med. 2:293-298.
3. Ohno, T., D. Gordon, H. San, V.J. Pompili, M.J. Imperiale, G.J. Nabel, and E.G. Nabel. 1994. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science (Wash. DC). 265:781-784.
4. Guzman, R.J., E.A. Hirschowitz, S.L. Brody, R.G. Crystal, S.E. Epstein, and T. Finkel. 1994. In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA. 91:10732-10736.
5. Chang, M.W., E. Barr, J. Seltzer, Y.-Q. Jiang, G.J. Nabel, E.G. Nabel, M.S. Parmacek, and J.M. Leiden. 1995. Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product. Science (Wash. DC). 267:518-522.
6. Lemarchand, P., M. Jones, I. Yamada, and R.G. Crystal. 1993. In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors. Circ. Res. 72:1132-1138.
7. Guzman, R.J., P. Lemarchand, R.G. Crystal, S.E. Epstein, and T. Finkel. 1993. Efficient and selective adenovirus-mediated gene transfer into vascular neointima. Circulation. 88:2838-2848.
8. Steg, P.G., L.J. Feldman, J.-Y. Scoazec, O. Tahlil, J.J. Barry, S. Boulechfar, T. Ragot, J.M. Isner, and M. Perricaudet. 1994. Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector. Circulation. 90:1648-1656.
9. Engelhardt, J.F., L. Litzky, and J.M. Wilson. 1994. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5:1217-1229.
10. Wilmott, R.W., R.S. Amin, C.R. Perez, S.E. Wert, G. Keller, G.P. Boivin, R. Hirsch, J. De Inocencio, P. Lu, S.F. Reising, et al. 1996. Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates. Hum. Gene Ther. 7:301-318.
11. Yang, Y., F.A. Nunes, K. Berencsi, E.E. Furth, E. Gönczöl, and J.M. Wilson. 1994. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA. 91:4407-4411.
12. Yang, Y., H.C.J. Ertl, and J.M. Wilson. 1994. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity. 1:433-442.
13. Yang, Y., Q. Li, H.C.J. Ertl, and J.M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015.
14. Roessler, B.J., E.D. Allen, J.M. Wilson, J.W. Hartman, and B.L. Davidson. 1993. Adenoviral-mediated gene transfer to rabbit synovium in vivo. J. Clin. Invest. 92:1085-1092.
15. Dong, J.-Y., D. Wang, F.W. Van Ginkel, D.W. Pascual, and R.A. Frizzell. 1996. Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector. Hum. Gene Ther. 7:319-331.
16. Knowles, M.R., K.W. Hohneker, Z. Zhou, J.C. Olsen, T.L. Noah, P.-C. Hu, M.W. Leigh, J.F. Engelhardt, L.J. Edwards, K.R. Jones, et al. 1995. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N. Engl. J. Med. 333:823-831.
17. Crystal, R.G., N.G. McElvaney, M.A. Rosenfeld, C.-S. Chu, A. Mastrangeli, J.G. Hay, S.L. Brody, H.A. Jaffe, N.T. Eissa, and C. Danel. 1994. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat. Genet. 8:42-51.
18. Zabner, J., L.A. Couture, R.J. Gregory, S.M. Graham, A.E. Smith, and M.J. Welsh. 1993. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell. 75:207-216.
19. Schulick, A.M., K.D. Newman, R. Virmani, and D.A. Dichek. 1995. In vivo gene transfer into injured carotid arteries. Optimization and evaluation of acute toxicity. Circulation. 91:2407-2414.
20. Newman, K.D., P.F. Dunn, J.W. Owens, A.H. Schulick, R. Virmani, G. Sukhova, P. Libby, and D.A. Dichek. 1995. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J. Clin. Invest. 96:2955-2965.
21. Horwitz, M.S. 1990. Adenoviruses. In Virology. 2nd ed. Vol. 2. B.N. Fields, D.M. Knipe, R.M. Chanock, M.S. Hirsch, J.L. Melnick, T.P. Monath, and B. Roizman, editors. Raven Press, New York. 1723-1740.
22. Flomenberg, P., V. Piaskowski, R.L. Truitt, and J.T. Casper. 1995. Characterization of human proliferative T cell responses to adenovirus. J. Infect. Dis. 171:1090-1096.
23. Lee, S.W., B.C. Trapnell, J.J. Rade, R. Virmani, and D.A. Dichek. 1993. In vivo adenoviral vector-mediated gene transfer into balloon-injured rat carotid arteries. Circ. Res. 73:797-807.
24. Liu, J.M., H. Fujii, S.W. Green, N. Komatsu, N.S. Young, and T. Shimada. 1991. Indiscriminate activity from the B19 parvovirus P6 promoter in nonpermissive cells. Virology. 182:361-364.
25. Schulick, A.H., G. Dong, K.D. Newman, R. Virmani, and D.A. Dichek. 1995. Endothelium-specific in vivo gene transfer. Circ. Res. 77:475-485.
26. Nicolls, M.R., G.G. Aversa, N.W. Pearce, A. Spinelli, M.F. Berger, K.E. Gurley, and B.M. Hall. 1993. Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Transplantation (Baltimore). 55:459-468.
27. De Jonge, M.W.A., L. De Leij, G. Mesander, G.J. Deenen, D. Opstelten, F.G.M. Kroese, G.W. van Imhoff, P. Nieuwenhuis, and T.H. The. 1989. LAMA tumor in the rat as an experimental model for pre-B-cell leukemia. Cancer Res. 49:5682-5688.
28. Seth, P., M. Rosenfeld, J. Higginbotham, and R.G. Crystal. 1994. Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA. J. Virol. 68: 933-940.
29. Cotten, M., M. Saltik, M. Kursa, E. Wagner, G. Maass, and M.L. Birnstiel. 1994. Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid. Virology. 205:254-261.
30. Yoshimura, K., M.A. Rosenfeld, P. Seth, and R.G. Crystal. 1993. Adenovirus-mediated augmentation of cell transfection with unmodified plasmid vectors. J. Biol. Chem. 268:2300-2303.
31. Smith, T.A.G., M.G. Mehaffey, D.B. Kayda, J.M. Saunders, S. Yei, B.C. Trapnell, A. McClelland, and M. Kaleko. 1993. Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice. Nat. Genet. 5:397-402.
32. Bersot, T.P., S.J. Russell, S.R. Thatcher, N.K. Pomernacki, R.W. Mahley, K.H. Weisgraber, T.L. Innerarity, and C.S. Fox. 1993. A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-1OO in a Chinese man discovered during a study of the prevalence of this disorder. J. Lipid Res. 34:1149-1154.
33. Zar, J.H. 1984. Biostatistical Analysis. Prentice-Hall, Englewood Cliffs, NJ.
34. Tripathy, S.K., H.B. Black, E. Goldwasser, and J.M. Leiden. 1996. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat. Med. 2: 545-550.
35. Engelhardt, J.F., X. Ye, B. Doranz, and J.M. Wilson. 1994. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA. 91: 6196-6200.
36. Fisher, K.J., H. Choi, J. Burda, S.-J. Chen, and J.M. Wilson. 1996. Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology. 217:11-22.
37. Mitani, K., F.L. Graham, C.T. Caskey, and S. Kochanek. 1995. Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector. Proc. Natl. Acad. Sci. USA. 92:3854-3858.
38. Thürmann, P.A., C. Sonnenburg-Chatzopoulos, and R. Lissner. 1995. Pharmacokinetic characteristics and tolerability of a novel intravenous immunoglobulin preparation. Eur. J. Clin. Pharmacol. 49:237-242.
39. Dai, Y., E.M. Schwarz, D. Gu, W.-W. Zhang, N. Sarvetnick, and I.M. Verma. 1995. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA. 92:1401-1405.
40. Ueno, H., J.-J. Li, H. Tomita, H. Yamamoto, Y. Pan, Y. Kanegae, I. Saito, and A. Takeshita. 1995. Quantitative analysis of repeat adenovirus-mediated gene transfer into injured canine femoral arteries. Arterioscler. Thromb. Vasc. Biol. 15:2246-2253.
41. Lim, C.S., G.D. Chapman, R.S. Gammon, J.B. Muhlestein, R.P. Bauman, R.S. Stack, and J.L. Swain. 1991. Direct in vivo gene transfer into the coronary and peripheral vasculatures of the intact dog. Circulation. 83:2007-2011.
42. Flugelman, M.Y., M.T. Jaklitsch, K.D. Newman, W. Casscells, G.L. Bratthauer, and D.A. Dichek. 1992. Low level in vivo gene transfer into the arterial wall through a perforated balloon catheter. Circulation. 85:1110-1117.
43. Lynch, C.M., M.M. Clowes, W.R.A. Osborne, A.W. Clowes, and A.D. Miller. 1992. Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model for gene therapy. Proc. Natl. Acad. Sci. USA. 89:1138-1142.
44. Leclerc, G., D. Gal, S. Takeshita, S. Nikol, L. Weir, and J.M. Isner. 1992. Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries. J. Clin. Invest. 90:936-944.
45. Yang, Y., F.A. Nunes, K. Berencsi, E. Gönczöl, J.F. Engelhardt, and J.M. Wilson. 1994. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat. Genet. 7:362-369.
46. Kochanek, S., P.R. Clemens, K. Mitani, H.-H. Chen, S. Chan, and C.T. Caskey. 1996. A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and β-galactosidase. Proc Natl. Acad. Sci. USA. 93:5731-5736.
47. Kay, M.A., A.-X. Holterman, L. Meuse, A. Gown, H.D. Ochs, P.S. Linsley, and C.B. Wilson. 1995. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat. Genet. 11:191-197.
48. Roselaar, S.E., G. Schonfeld, and A. Daugherty. 1995. Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity. J. Clin. Invest. 96:1389-1394.