Modulation of aldosterone and cortisol synthesis on the molecular level

Molecular and Cellular Endocrinology

Volumn 215, Issue 1-2, 2004, Pages 149-159

  Lisurek, Michael ^a   Bernhardt, Rita ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

11 Hydroxylase; Aldosterone synthase; CYP11B1; CYP11B2; Cytochrome P450; Glucocorticoids; Mineralocorticoids

Indexed keywords

ADRENODOXIN; ALDOSTERONE; ALDOSTERONE SYNTHASE; CORTICOSTEROID; CYTOCHROME P450; CYTOCHROME P450 CYP11B1; GLUCOCORTICOID; HYDROCORTISONE; MINERALOCORTICOID; STEROID 11BETA MONOOXYGENASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CONFERENCE PAPER; ENDOCRINE DISEASE; ENZYME ACTIVITY; HORMONAL REGULATION; HORMONE DETERMINATION; HORMONE STRUCTURE; HORMONE SYNTHESIS; HUMAN; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STEROID HYDROXYLATION; TRANSCRIPTION REGULATION;

ADRENODOXIN; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANIMALS; CATTLE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; MODELS, MOLECULAR; MUTATION; OXIDATION-REDUCTION; PROTEIN CONFORMATION; STEROID 11-BETA-HYDROXYLASE;

EID: 1542617034     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2003.11.008     Document Type: Conference Paper

References (112)

1. Akhrem A.A., Lapko V.N., Lapko A.G., Shkumatov V.M., Chashchin V.L. Isolation, structural organization and mechanism of action of mitochondrial steroid hydroxylating systems. Acta Biol. Med. Ger. 38:1979;257-273.
2. Azeva T.N., Gilep A.A., Lepesheva G.I., Strushkevich N.V., Usanov S.A. Site-directed mutagenesis of cytochrome P450scc. II. Effect of replacement of the Arg425 and Arg426 residues on the structural and functional properties of the cytochrome P450scc. Biochemistry (Moscow). 66:2001;546-575.
3. Bechtel S., Belkina N., Bernhardt R. The effect of amino acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme. Eur. J. Biochem. 269:2002;1118-1127.
4. Beckert V., Dettmer R., Bernhardt R. Mutations of tyrosine 82 in bovine adrenodoxin that affect binding to cytochromes P45011A1 and P45011B1 but not electron transfer. J. Biol. Chem. 269:1994;2568-2573.
5. Beckert V., Bernhardt R. Specific aspects of electron transfer from adrenodoxin to cytochromes p450scc and p45011beta. J. Biol. Chem. 272:1997;4883-4888.
6. Belkina N.V., Lisurek M., Ivanov A.S., Bernhardt R. Modelling of three-dimensional structures of cytochromes P450 11B1 and 11B2. J. Inorg. Biochem. 87:2001;197-207.
7. Bernhardt R. Cytochrome P450: structure, function, and generation of reactive oxygen species. Rev. Physiol. Biochem. Pharmacol. 127:1996;137-221.
8. Bernhardt, R., 1998. Electron transfer in mitochondrial steroid hydroxylating cytochrome P450 systems: role of adrenodoxin. In: Nicolini, C. (Ed.), Biophysics of Electron Transfer and Molecular Bioelectronics. Plenum Press, New York, pp. 51-66.
9. Boon W.C., Roche P.J., Hammond V.E., Jeyaseelan K., Crawford R.J., Coghlan J.P. Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep. Biochim. Biophys. Acta. 1260:1995;109-112.
10. Böttner B., Schrauber H., Bernhardt R. Engineering a mineralocorticoid- to a glucocorticoid-synthesizing cytochrome P450. J. Biol. Chem. 271:1996;8028-8033.
11. Böttner B., Bernhardt R. Changed ratios of glucocorticoid/ mineralocorticoids caused by point mutations in the putative I-helix regions of CYP11B1 and CYP11B2. Endocr. Res. 22:1996;455-561.
12. Böttner B., Denner K., Bernhardt R. Conferring aldosterone synthesis to human CYP11B1 by replacing key amino acid residues with CYP11B2-specific ones. Eur. J. Biochem. 252:1998;458-466.
13. Brilla C.G. Renin-angiotensin-aldosterone system and myocardial fibrosis. Cardiovasc. Res. 47:2000;1-3.
14. Bülow H.E., Mobius K., Bahr V., Bernhardt R. Molecular cloning and functional expression of the cytochrome P450 11β-hydroxylase of the guinea pig. Biochem. Biophys. Res. Commun. 221:1996;304-312.
15. Bülow H.E., Bernhardt R. Analysis of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity. Eur. J. Biochem. 269:2002;3838-3846.
16. Bureik M., Lisurek M., Bernhardt R. The human steroid hydroxylases CYP11B1 and CYP11B2. Biol. Chem. 383:2002a;1537-1551.
17. Bureik M., Zeeh A., Bernhardt R. Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors. Endocr. Res. 28:2002b;351-355.
18. Bureik M., Schiffler B., Hiraoka Y., Vogel F., Bernhardt R. Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1. Biochemistry. 41:2002c;2311-2321.
19. Chua S.C., Szabo P., Vitek A., Grzeschik K.H., John M., White P.C. Cloning of cDNA encoding steroid 11β-hydroxylase (P450c11). Proc. Natl. Acad. Sci. U.S.A. 84:1987;7193-7197.
20. Cao P.-R., Bernhardt R. Modulation of aldosterone biosynthesis by adrenodoxin mutants with different electron transport efficiencies. Eur. J. Biochem. 265:1999a;152-159.
21. Cao P.-R., Bernhardt R. Interaction of CYP11B1 (cytochrome P-45011 b) with CYP11A1 (cytochrome P-450scc) in COS-1 cells. Eur. J. Biochem. 262:1999b;720-726.
22. Coghlan V.M., Vickery L.E. Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc. J. Biol. Chem. 266:1991;18606-18612.
23. Coghlan V.M., Vickery L.E. Electrostatic interactions stabilizing ferredoxin electron transfer complexes. Disruption by 'conservative' mutations. J. Biol. Chem. 267:1992;8932-8935.
24. Connell J.M., Fraser R., MacKenzie S., Davies E. Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension. 41:2003;993-999.
25. Cosme J., Johnson E.F. Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding. J. Biol. Chem. 275:2000;2545-2553.
26. Curnow K.M., Tusie-Luna M.T., Pascoe L., Natarajan R., Gu J.L., Nadler J.L., White P.C. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol. Endocrinol. 5:1991;1513-1522.
27. Curnow K.M., Slutsker L., Vitek J., Cole T., Speiser P.W., New M.I., White P.C., Pascoe L. Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8. Proc. Natl. Acad. Sci. U.S.A. 90:1993;4552-4556.
28. Curnow K.M., Mulatero P., Emeric-Blanchouin N., Aupetit-Faisant B., Corvol P., Pascoe L. The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme. Nat. Struct. Biol. 4:1997;32-35.
29. Delles C., Erdmann J., Jacobi J., Hilgers K.F., Fleck E., Regitz-Zagrosek V., Schmieder R.E. Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension. J. Am. Coll. Cardiol. 37:2001;878-884.
30. Denner K., Doehmer J., Bernhardt R. Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 Chinese hamster cells. Endocr. Res. 21:1995;443-448.
31. Denner, K., Bernhardt, R., 1998. Inhibition studies of steroid conversions mediated by human CYP11B1 and CYP11B2 expressed in cell cultures. In: Ishimura, Y., Shimada, H., Suematsu, M. (Eds.), Oxygen Homeostasis and Its Dynamics. Springer-Verlag, Tokyo, Berlin, Heidelberg, New York, pp. 231-236.
32. Domalik L.J., Chaplin D.D., Kirkman M.S., Wu R.C., Liu W.W., Howard T.A., Seldin M.F., Parker K.L. Different isozymes of mouse 11β-hydroxylase produce mineralocorticoids and glucocorticoids. Mol. Endocrinol. 5:1991;1853-1861.
33. Ehmer P.B., Bureik M., Bernhardt R., Müller U., Hartmann R.W. Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells. J. Steroid Biochem. Mol. Biol. 81:2002;173-179.
34. Erdmann B., Denner K., Gerst H., Lenz D., Bernhardt R. Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures. Endocr. Res. 21:1995a;425-435.
35. Erdmann B., Gerst H., Bülow H., Lenz D., Bahr V., Bernhardt R. Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes. Histochem. Cell. Biol. 104:1995b;301-307.
36. Erdmann B., Gerst H., Lippoldt A., Bülow H., Ganten D., Fuxe K., Bernhardt R. Expression of cytochrome P45011B1 in the brain of normal hypertensive transgenic rats. Brain Res. 733:1996;73-82.
37. Fardella C.E., Rodriguez H., Hum D.W., Mellon S.H., Miller W.L. Artificial mutations in P450AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension? J. Clin. Endocrinol. Metab. 80:1995;1040-1043.
38. Ferrari P. Genetics of the mineralocorticoid system in primary hypertension. Curr. Hypertens. Rep. 4:2002;18-24.
39. Fisher A., Friel E.C., Bernhardt R., Gomez-Sanchez C., Connell J.M., Fraser R., Davies E. Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11β-hydroxylase. J. Clin. Endocrinol. Metab. 86:2001;4326-4329.
40. Geley S., Johrer K., Peter M., Denner K., Bernhardt R., Sippell W.G., Kofler R. Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency. J. Clin. Endocrinol. Metab. 80:1995;424-429.
41. Geley S., Kapelari K., Johrer K., Peter M., Glatzl J., Vierhapper H., Schwarz S., Helmberg A., Sippell W.G., White P.C., Kofler R. CYP11B1 mutations causing congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency. J. Clin. Metab. 81:1996;2896-2901.
42. Gotoh O. Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J. Biol. Chem. 267:1992;83-90.
43. Hampf M., Swart A.C., Swart P. Sequence of the 11beta-hydroxylase gene from the cape baboon (Papio ursinus). Endocr. Res. 22:1996;495-499.
44. Hampf M., Dao N.T., Hoan N.T., Bernhardt R. Unequal crossing-over between aldosterone synthase and 11beta-hydroxylase genes causes congenital adrenal hyperplasia. J. Clin. Endocrinol. Metab. 86:2001;4445-4452.
45. Hanukoglu I., Hanukoglu Z. Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation. Eur. J. Biochem. 157:1986;27-31.
46. Hasemann C.A., Kurumbail R.G., Boddupalli S.S., Peterson J.A., Deisenhofer J. Structure and function of cytochromes P450: a comparative analysis of three crystal structures. Structure. 3:1995;41-62.
47. Hautanen A., Toivanen P., Manttari M., Tenkanen L., Kupari M., Manninen V., Kayes K.M., Rosenfeld S., White P.C. Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction. Circulation. 100:1999;2213-2218.
48. Hiwatashi A., Sakihama N., Shin M., Ichikawa Y. Heterogeneity of adrenocortical ferredoxin. FEBS Lett. 209:1986;311-315.
49. Imai T., Yamazaki T., Kominami S. Kinetic studies on bovine cytochrome p45011 b catalyzing successive reactions from 11-deoxycorticosterone to aldosterone. Biochemistry. 37:1998;8097-8104.
50. Ikushiro S., Kominami S., Takemori S. Adrenal P-450scc modulates activity of P-45011 b in liposomal and mitochondrial membranes. Implication of P-450scc in zone specificity of aldosterone biosynthesis in bovine adrenal. J. Biol. Chem. 267:1992;1464-1469.
51. Joehrer K., Geley S., Strasser-Wozak E.M., Azziz R., Wollmann H.A., Schmitt K., Kofler R., White P.C. CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11beta-hydroxylase deficiency. Hum. Mol. Genet. 6:1997;1829-1834.
52. Kawamoto T., Mitsuuchi Y., Ohnishi T., Ichikawa Y., Yokoyama Y., Sumimoto H., Toda K., Miyahara K., Kuribayashi I., Nakao K. Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism. Biochem. Biophys. Res. Commun. 173:1990a;309-316.
53. Kawamoto T., Mitsuuchi Y., Toda K., Miyahara K., Yokoyama Y., Nakao K., Hosoda K., Yamamoto Y., Imura H., Shizuta Y. Cloning of cDNA and genomic DNA for human cytochrome P-45011 β FEBS Lett. 269:1990b;345-349.
54. Kominami S., Harada D., Takemori S. Regulation mechanism of the catalytic activity of bovine adrenal cytochrome P-450(11)b. Biochim. Biophys. Acta. 1192:1994;234-240.
55. Kupari M., Hautanen A., Lankinen L., Koskinen P., Virolainen J., Nikkila H., White P.C. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Circulation. 97:1998;569-575.
56. Lepesheva G.I., Azeva T.N., Srushkevich N.V., Gilep A.A., Usanov S.A. Site-directed mutagenesis of cytochrome P450scc (CYP11A1). Effect of lysine residue substitution on its structural and functional properties. Biochemistry (Moscow). 65:2000;1409-1418.
57. Lifton R.P., Dluhy R.G., Powers M., Rich G.M., Cook S., Ulick S., Lalouel J.M. A chimaeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature. 355:1992;262-265.
58. Lifton R.P., Gharavi A.G., Geller D.S. Molecular mechanisms of human hypertension. Cell. 104:2001;545-556.
59. Lijnen P., Petrov V. Induction of cardiac fibrosis by aldosterone. J. Mol. Cell. Cardiol. 32:2000;865-879.
60. Lim P.O., Macdonald T.M., Holloway C., Friel E., Anderson N.H., Dow E., Jung R.T., Davies E., Fraser R., Connell J.M. Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. J. Clin. Endocrinol. Metab. 87:2002;4398-4402.
61. MacKenzie S.M., Clark C.J., Fraser R., Gomez-Sanchez C.E., Connell J.M., Davies E. Expression of 11beta-hydroxylase and aldosterone synthase genes in the rat brain. J. Mol. Endocrinol. 24:2000;321-328.
62. MacConnachie A.A., Kelly K.F., Mcnamara A., Loughlin S., Gates L.J., Inglis G.C., Jamieson A., Connell J.M., Haites N.E. Rapid diagnosis and identification of cross-over sites in patients with glucocorticoid remediable aldosteronism. J. Clin. Endocrinol. Metab. 83:1998;4328-4331.
63. Mathew P.A., Mason J.I., Trant J.M., Sanders D., Waterman M.R. Amino acid substitutions Phe66Leu and Ser126Pro abolish cortisol and aldosterone synthesis by bovine cytochrome P450(11)b. J. Biol. Chem. 265:1990;20228-20233.
64. Matsukawa N., Nonaka Y., Ying Z., Higaki J., Ogihara T., Okamoto M. Molecular cloning and expression of cDNAS encoding rat aldosterone synthase: variants of cytochrome P-450(11 b). Biochem. Biophys. Res. Commun. 169:1990;245-252.
65. Mellon S.H., Bair S.R., Monis H. P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities. J. Biol. Chem. 270:1995;1643-1649.
66. Miller, W.L., Tyrell, J.B., 1995. The adrenal cortex. In: Felig, P., Baxter, J.D., Frohmann, L.A., Broadus, A.E. (Eds.), Endocrinology and Metabolism, third ed. McGraw-Hill Press, New York, USA, pp. 642-659.
67. Mornet E., Dupont J., Vitek A., White P.C. Characterization of two genes encoding human steroid 11 β-hydroxylase [P-450(11) β]. J. Biol. Chem. 264:1989;20961-20967.
68. Mulatero P., Curnow K.M., Aupetit-Taisant B., Foekling M. Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. J. Clin. Endocinol. Metab. 83:1998;3996-4001.
69. Nakagawa Y., Yamada M., Ogawa H., Igarashi Y. Missense mutation in CYP11B1 (CGA[Arg384] GCA[Gly]) causes steroid 11beta-hydroxylase deficiency. Eur. J. Endocrinol. 132:1995;286-289.
70. Nomoto S., Massa G., Mitani F., Ishimura Y., Miyahara K., Toda K., Nagano I., Yamashiro T., Ogoshi S., Fukata J., Onishi S., Hashimoto K., Doi Y., Imura H., Shizuta Y. CMO I deficiency caused by a point mutation in exon 8 of the human CYP11B2 gene encoding steroid 18-hydroxylase (P450C18). Biochem. Biophys. Res. Commun. 234:1997;382-385.
71. Nonaka Y., Takemori H., Halder S.K., Sun T., Ohta M., Hatano O., Takakusu A., Okamoto M. Frog cytochrome P-450 (11 b,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis. Eur. J. Biochem. 229:1995;249-256.
72. Nonaka Y., Fujii T., Kagawa N., Waterman M.R., Takemori H., Okamoto M. Structure/function relationship of CYP11B1 associated with Dahl's salt-resistant rats - expression of rat CYP11B1 and CYP11B2 in Escherichia coli. Eur. J. Biochem. 258:1998;869-878.
73. Ogishima T., Shibata H., Shimada H., Mitani F., Suzuki H., Saruta T., Ishimura Y. Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism. J. Biol. Chem. 266:1991;10731-10734.
74. Ohnishi T., Wada A., Nonaka Y., Okamoto M., Yamano T. Effect of phospholipid on aldosterone biosynthesis by a cytochrome P- 450(11) β-reconstituted system. Biochem. Int. 9:1984;715-723.
75. Ohnishi T., Wada A., Nonaka Y., Sugiyama T., Yamano T., Okamoto M. Effect of calmodulin on aldosterone synthesis by a cytochrome P-450(11) β-reconstituted system from bovine adrenocortical mitochondria. J. Biochem. (Tokio). 100:1986;1065-1076.
76. Ortiz De Montellano, P.R., 1995. Oxygen activation and reactivity. In: Ortiz De Montellano, P.R. (Ed.), Cytochrome P450: Stucture, Mechanism and Biochemistry. Plenum Press, New York, USA, pp. 245-303.
77. Ozaki H.S., Iwahashi K., Tsubaki M., Fukui Y., Ichikawa Y., Takeuchi Y. Cytochrome P-45011 beta in rat brain. J. Neurosci. Res. 28:1991;518-524.
78. Pascoe L., Curnow K.M., Slutsker L., Connell J.M., Rösler A., White P.C. Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. Proc. Natl. Acad. Sci. U.S.A. 89:1992a;4996-5000.
79. Pascoe L., Curnow K.M., Slutsker L., Connell J.M., Speiser P.W., New M.I., White P.C. Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2. Proc. Natl. Acad. Sci. U.S.A. 89:1992b;8327-8331.
80. Pascoe L., Jeunemaitre X., Lebrethon M.C., Curnow K.M., Gomez-Sanchez C.E., Gasc J.M., Saez J.M., Corvol P. Glucocorticoid-suppressible hyperaldosteronism and adrenal tumours occurring in a single French pedigree. J. Clin. Invest. 96:1995;2236-2246.
81. Peter M., Bunger K., Solyom J., Sippell W.G. Mutation Thr185I is associated with corticosterone methyl oxidase deficiency type II. Eur. J. Pediatr. 157:1998;378-381.
82. Peter M., Dubuis J.-M., Sippell W.G. Disorders of the aldosterone synthase and steroid 11β-hydroxylase deficiencies. Horm. Res. 51:1999;211-222.
83. Pitt B. Do diuretics and aldosterone receptor antagonists improve ventricular remodeling? J. Card. Fail. 8:2002;491-493.
84. Portrat-Doyen S., Tourniaire T., Richard O., Mulatero P., Aupetit-Faisant B., Curnow K.M., Pascoe L., Morel Y. Isolated aldosterone synthase deficiencies caused by simultaneous E198D and V386A mutations in the CYP11B2 gene. J. Clin. Endocrinol. Metab. 83:1998;4156-4161.
85. Quinn S.J., Williams G.H. Regulation of aldosterone secretion. Annu. Rev. Physiol. 50:1988;409-426.
86. Raag R., Martinis S.A., Sligar S.G., Poulos T.L. Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala. Biochemistry. 30:1991;11420-11429.
87. Ravichandran K.G., Boddupalli S.S., Hasermann C.A., Peterson J.A., Deisenhofer J. Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's. Science. 261:1993;731-736.
88. Rudolph A.E., Blasi E.R., Delyani J.A. Tissue-specific corticosteroidogenesis in the rat. Mol. Cell. Endocrinol. 165:2000;221-224.
89. Sakihama N., Hiwatashi A., Miyatake A., Shin M., Ichikawa Y. Isolation and purification of mature bovine adrenocortical ferredoxin with an elongated carboxyl end. Arch. Biochem. Biophys. 264:1988;23-29.
90. Schunkert H., Hengstenberg C., Holmer S.R., Broeckel U., Luchner A., Muscholl M.W., Kurzinger S., Doring A., Hense H.W., Riegger G.A. Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure. Circulation. 99:1999;2255-2260.
91. Seeman T., Widimsky J., Hampf M., Bernhardt R. Abolished nocturnal blood pressure fall in a boy with glucocorticoid-remediable aldosteronism. J. Hum. Hypertens. 13:1999;823-828.
92. Seybert D.W. Lipid regulation of bovine cytochrome P450(11) b activity. Arch. Biochem. Biophys. 279:1990;188-194.
93. Swart A.C., Brown N., Kolar N., Swart P. Baboon cytochrome P450c11 is encoded by more than one gene. Endocr. Res. 26:2000;1011-1018.
94. Takeda M., Yoneda T., Demura M., Mijamori I., Mabuchi H. Sodium-induced cardic aldosterone synthesis causes cardic hypertension. Endocrinol. 141:2000;1901-1904.
95. Tanaka M., Haniu M., Yasunobu K.T., Kimura T. The amino acid sequence of bovine adrenodoxin. J. Biol. Chem. 248:1973;1141-1157.
96. Taymans S.E., Pack S., Pak E., Torpy D.J., Zhuang Z., Stratakis C.A. Human CYP11B2 (aldosterone synthase) maps to chromosome 8q24.3. J. Clin. Endocrinol. Metab. 83:1998;1033-1036.
97. Uhlmann H., Kraft R., Bernhardt R. C-terminal region of adrenodoxin affects its structural integrity and determines differences in its electron transfer function to cytochrome P-450. J. Biol. Chem. 269:1994;22557-22564.
98. Veronneau S., Bernard H., Cloutier M., Courtemanche J., Ducharme L., Lefebvre A., Mason J.I., LeHoux J.G. The hamster adrenal cytochrome P450C11 has equipotent 11-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity. J. Steroid Biochem. Mol. Biol. 57:1996;125-139.
99. Wada A., Okamoto M., Nonaka Y., Yamano T. Aldosterone biosynthesis by a reconstituted cytochrome P-45011 b system. Biochem. Biophys. Res. Commun. 119:1984;365-371.
100. Wada A., Ohnishi T., Nonaka Y., Okamoto M., Yamano T. Synthesis of aldosterone by a reconstituted system of cytochrome P- 45011 b from bovine adrenocortical mitochondria. J. Biochem. (Tokyo). 98:1985;245-256.
101. Wada A., Waterman M.R. Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding. J. Biol. Chem. 267:1992;22877-22882.
102. Wagner M.J., Ge Y., Siciliano M., Wells D.E. A hybrid cell mapping panel for regional localization of probes to human chromosome 8. Genomics. 10:1991;114-125.
103. Waterman M.R., Simson E.R. Regulation of steroid hydroxylase gene expression is multifunctional in nature. Recent Prog. Horm. Res. 45:1989;533-563.
104. White P.C., Dupont J., New M.I., Leibermann E., Hochberg Z., Rösler A. A mutation in CYP11B1 (Arg448His) associated with steroid 11β-hydroxylase deficiency in Jews of Moroccan origin. J. Clin. Invest. 87:1991;1664-1667.
105. White P.C. Steroid 11 β-hydroxylase deficiency and related disorders. Endocrinol. Metab. Clin. North Am. 30:2001;61-79.
106. Williams P.A., Cosme J., Sridhar V., Johnson E.F., McRee D.E. Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity. Mol. Cell. 5:2000;121-131.
107. Williams P.A., Cosme J., Ward A., Angove H.C., Matak Vinkovic D., Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 424:2003;464-468.
108. Yamazaki T., Mcnamara B.C., Jefcoate C.R. Competition for electron transfer between cytochromes P450scc and P45011 b in rat adrenal mitochondria. Mol. Cell. Endocrinol. 95:1993;1-11.
109. Yanagibashi K., Haniu M., Shively J.E., Shen W.H., Hall P. The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldosterone synthesis. J. Biol. Chem. 261:1986;3556-3562.
110. Yoshimura M., Nakamura S., Ito T., Nakayama M., Harada E., Mizuno Y., Sakamoto T., Yamamuro M., Saito Y., Nakao K., Yasue H., Ogawa H. Expression of aldosterone synthase gene in failing human heart: quantitative analysis using modified real-time polymerase chain reaction. J. Clin. Endocrinol. Metab. 87:2002;3936-3940.
111. Young L.S., Murphy G., Kelly S.N., Smith T.P., Cunningham S.K., McKenna T.J. Differential production of adrenal steroids by purified cells of the human adrenal cortex is relative rather than absolute. Eur. J. Endocrinol. 148:2003;139-145.
112. Zuber M.X., Mason J.I., Simpson E.R., Waterman M.R. Simultaneous transfection of COS-1 cells with mitochondrial and microsomal steroid hydroxylases: incorporation of a steroidogenic pathway into nonsteroidogenic cells. Proc. Natl. Acad. Sci. U.S.A. 85:1988;699-703.