Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11β-hydroxylase

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 9, 2001, Pages 4326-4329

  Fisher, Angela ^a   Friel, Elaine C ^a   Bernhardt, Rita ^b   Gomez Sanchez, Celso ^c   Connell, John M C ^a   Fraser, Robert ^a   Davies, Eleanor ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

18 HYDROXYDEOXYCORTICOSTERONE; 18 HYDROXYHYDROCORTISONE; 18 OXOHYDROCORTISONE; ALDOSTERONE; ALDOSTERONE SYNTHASE; CORTICOSTEROID; CORTODOXONE; DEOXYCORTICOSTERONE; HYDROCORTISONE; STEROID 11BETA MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; HORMONE SYNTHESIS; HUMAN; HYPERALDOSTERONISM; NONHUMAN; PRIORITY JOURNAL; STEROIDOGENESIS; ZONA FASCICULATA;

ADRENAL CORTEX HORMONES; ALDOSTERONE SYNTHASE; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; HYDROXYSTEROIDS; KINETICS; STEROID 11-BETA-HYDROXYLASE;

ANIMALIA;

EID: 0034853298     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.9.4326     Document Type: Article

References (19)

1. 18 Hydroxycorticosterone: A review
2. Quantitation of cortisol and related 3-oxo-4-ene steroids in urine using gas chromatography/mass spectrometry with stable isotope-labelled internal standards
3. Hypersecretion of a new corticosteroid, 18-hydroxycortisol in 2 types of adrenocortical hypertension
4. Defective zona fasciculata function as the mechanism of glucocorticoid-remediable hyperaldosteronism
5. A chimaeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
6. Abnormality of aldosterone and cortisol late pathways in glucocorticoid-remediable aldosteronism
7. Altered 11β-hydroxylase activity in glucocorticoid-suppressible hyperaldosteronism
8. Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors
9. Cloning of CYP11B1 and CYP11B2 from normal human adrenals and their functional expression in COS- and V79 Chinese hamster cells
10. Amino acid residue 147 of human aldosterone synthase and 11β-hydroxylase plays a key role in 11β-hydroxylation
11. Origin of aldosterone secretion in trypsin-stimulated rat adrenal zona glomerulosa incubations
12. Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree
13. In vitro modification of rat adrenal zona fasciculata/reticularis function by the zona glomerulosa
14. Cortisol: A tool to study aldosterone biosynthesis in rats
15. The hybrid rat cytochrome P450 containing the first 5 exons of the CYP11B1 and last 4 exons from the CYP11B2 enzyme retains 11β-hydroxylase activity, but the alternative hybrid is inactive
16. Kinetic analysis of bovine cytochrome P45011β catalysing successive reactions from deoxycorticosterone to aldosterone
17. A two cell type theory of aldosterone biosynthesis. The roles of 11β-hydroxylase and aldosterone synthase and a high capacity, tightly binding steroid carrier for 18-deoxydeoxycorticosterone in rat adrenal
18. Molecular biology of rat steroid 11β-hydroxylase [P-450(11β)] and aldosterone synthase [P-450(11β, aldo)]