The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme

Nature Structural Biology

Volumn 4, Issue 1, 1997, Pages 32-35

  Curnow, K M ^a   Mulatero, P ^a   Emeric Blanchouin, N ^a   Aupetit Faisant, B ^a   Corvol, P ^a   Pascoe, L ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALDOSTERONE; COMPLEMENTARY DNA; GLYCINE; HYDROCORTISONE; SERINE; STEROID 11BETA MONOOXYGENASE; VALINE;

ALDOSTERONE RELEASE; AMINO ACID SUBSTITUTION; ARTICLE; DNA TRANSFECTION; ENZYME ACTIVITY; ENZYME MECHANISM; ESSENTIAL HYPERTENSION; GENE CONVERSION; HYDROCORTISONE RELEASE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STEROIDOGENESIS;

ALDOSTERONE; AMINO ACID SEQUENCE; AMINO ACIDS; DNA, COMPLEMENTARY; HUMANS; HYDROCORTISONE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STEROID 11-BETA-HYDROXYLASE; TRANSFECTION;

EID: 0031025104     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0197-32     Document Type: Article

References (26)