Expression of aldosterone synthase gene in failing human heart: Quantitative analysis using modified real-time polymerase chain reaction

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 8, 2002, Pages 3936-3940

  Yoshimura, Michihiro ^a   Nakamura, Shota ^b   Ito, Teruhiko ^c   Nakayama, Masafumi ^d   Harada, Eisaku ^a   Mizuno, Yuji ^b   Sakamoto, Tomohiro ^c   Yamamuro, Megumi ^d   Saito, Yoshihiko ^a   Nakao, Kazuwa ^b   Yasue, Hirofumi ^c   Ogawa, Hisao ^d  

^a KUMAMOTO UNIVERSITY   (Japan)

^b Kumamoto Aging Research Institute   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; RNA;

ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DNA TEMPLATE; FEMALE; GENE EXPRESSION; HEART FAILURE; HEART LEFT VENTRICLE; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

EID: 18544389493     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.87.8.8731     Document Type: Article

References (24)

1. Circulating versus local renin-angiotensin system in cardiovascular homeostasis
2. Inotropic effects of angiotensin II on human cardiac muscle in vitro
3. Disorders of aldosterone biosynthesis and action
4. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload ventricular hypertrophy: Effects on coronary resistance, contractility, and relaxation
5. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system
6. Expression of angiotensin-converting enzyme in remaining viable myocyte of human ventricle after myocardial infarction
7. Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells
8. Activation of cardiac aldosterone production in rat myocardial infarction: Effect of angiotensin II receptor blockade and role in cardiac fibrosis
9. Aldosterone production is activated in the failing ventricles in humans
10. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex
11. Molecular biology of steroid hormone synthesis
12. Characterization of two genes encoding human steroid 11β-hydroxylase (P-450(11)β)
13. Real-time quantitative PCR
14. A novel method for real-time quantitative RT-PCR
15. Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes
16. Steroidogenic enzyme gene expression in the human heart
17. Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide
18. Inhibition of aldosterone production in the adrenal glomerulosa by atrial natriuretic factor
19. Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure
20. The effect of spironolactone on morbidity and mortality in patients with severe heart failure
21. Cardiac steroidogenesis in normal and failing heart
22. Editorial: Cardiac steroidogenesis: New sites of synthesis, or much ado about nothing?
23. Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure
24. Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction: Extracting aldosterone through the heart promotes ventricular remodeling after acute myocardial infarction