메뉴 건너뛰기




Volumn 320, Issue 2, 2004, Pages 313-329

Tip, an Lck-interacting protein of Herpesvirus saimiri, causes Fas- and Lck-dependent apoptosis of T lymphocytes

Author keywords

Apoptosis; EGFP; Enhanced green fluorescent protein; Fas; IL 2; kDa; Kilodalton; Lck; Lentiviral gene transfer; PBMC; Peripheral blood mononuclear cells; Protein tyrosine kinase; PTK; Saimiriine herpesvirus 2 (Herpesvirus saimiri); StpC; T lymphocytes; TCR; Tip

Indexed keywords

FAS ANTIGEN; INTERLEUKIN 2; PROTEIN KINASE LCK; PROTEIN TIP; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 1542375383     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2003.11.032     Document Type: Article
Times cited : (21)

References (71)
  • 1
    • 0025277298 scopus 로고
    • The divergence between two oncogenic herpesvirus saimiri strains in a genomic region related to the transforming phenotype
    • Biesinger B., Trimble J.J., Desrosiers R.C., Fleckenstein B. The divergence between two oncogenic herpesvirus saimiri strains in a genomic region related to the transforming phenotype. Virology. 176(2):1990;505-514.
    • (1990) Virology , vol.176 , Issue.2 , pp. 505-514
    • Biesinger, B.1    Trimble, J.J.2    Desrosiers, R.C.3    Fleckenstein, B.4
  • 3
    • 0028940769 scopus 로고
    • The product of the herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells
    • Biesinger B., Tsygankov A.Y., Fickenscher H., Emmrich F., Fleckenstein B., Bolen J.B., Broker B.M. The product of the herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J. Biol. Chem. 270(9):1995;4729-4734.
    • (1995) J. Biol. Chem. , vol.270 , Issue.9 , pp. 4729-4734
    • Biesinger, B.1    Tsygankov, A.Y.2    Fickenscher, H.3    Emmrich, F.4    Fleckenstein, B.5    Bolen, J.B.6    Broker, B.M.7
  • 4
    • 0032453708 scopus 로고    scopus 로고
    • Herpesvirus saimiri strategies for T cell stimulation and transformation
    • Broker B.M., Fickenscher H. Herpesvirus saimiri strategies for T cell stimulation and transformation. Med. Microbiol. Immunol. 187(3):1999;127-136.
    • (1999) Med. Microbiol. Immunol. , vol.187 , Issue.3 , pp. 127-136
    • Broker, B.M.1    Fickenscher, H.2
  • 5
    • 0027305396 scopus 로고
    • Immortalization of human T cell clones by herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors
    • Broker B.M., Tsygankov A.Y., Muller-Fleckenstein I., Guse A.H., Chitaev N.A., Biesinger B., Fleckenstein B., Emmrich F. Immortalization of human T cell clones by herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors. J. Immunol. 151(3):1993;1184-1192.
    • (1993) J. Immunol. , vol.151 , Issue.3 , pp. 1184-1192
    • Broker, B.M.1    Tsygankov, A.Y.2    Muller-Fleckenstein, I.3    Guse, A.H.4    Chitaev, N.A.5    Biesinger, B.6    Fleckenstein, B.7    Emmrich, F.8
  • 9
    • 0033757550 scopus 로고    scopus 로고
    • Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and herpesvirus saimiri
    • Damania B., Jung J.U. Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and herpesvirus saimiri. Adv. Cancer Res. 80:2001;51-82.
    • (2001) Adv. Cancer Res. , vol.80 , pp. 51-82
    • Damania, B.1    Jung, J.U.2
  • 11
    • 0031746909 scopus 로고    scopus 로고
    • Antiapoptotic activity of the herpesvirus saimiri-encoded Bcl-2 homolog: Stabilization of mitochondria and inhibition of caspase-3-like activity
    • Derfuss T., Fickenscher H., Kraft M.S., Henning G., Lengenfelder D., Fleckenstein B., Meinl E. Antiapoptotic activity of the herpesvirus saimiri-encoded Bcl-2 homolog: stabilization of mitochondria and inhibition of caspase-3-like activity. J. Virol. 72(7):1998;5897-5904.
    • (1998) J. Virol. , vol.72 , Issue.7 , pp. 5897-5904
    • Derfuss, T.1    Fickenscher, H.2    Kraft, M.S.3    Henning, G.4    Lengenfelder, D.5    Fleckenstein, B.6    Meinl, E.7
  • 12
    • 0031906144 scopus 로고    scopus 로고
    • STP and Tip are essential for herpesvirus saimiri oncogenicity
    • Duboise S.M., Guo J., Czajak S., Desrosiers R.C., Jung J.U. STP and Tip are essential for herpesvirus saimiri oncogenicity. J. Virol. 72(2):1998;1308-1313.
    • (1998) J. Virol. , vol.72 , Issue.2 , pp. 1308-1313
    • Duboise, S.M.1    Guo, J.2    Czajak, S.3    Desrosiers, R.C.4    Jung, J.U.5
  • 13
    • 0032478805 scopus 로고    scopus 로고
    • Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells
    • Feshchenko E.A., Langdon W.Y., Tsygankov A.Y. Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J. Biol. Chem. 273(14):1998;8323-8331.
    • (1998) J. Biol. Chem. , vol.273 , Issue.14 , pp. 8323-8331
    • Feshchenko, E.A.1    Langdon, W.Y.2    Tsygankov, A.Y.3
  • 15
    • 0029815220 scopus 로고    scopus 로고
    • Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes
    • Fickenscher H., Biesinger B., Knappe A., Wittmann S., Fleckenstein B. Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes. J. Virol. 70(9):1996;6012-6019.
    • (1996) J. Virol. , vol.70 , Issue.9 , pp. 6012-6019
    • Fickenscher, H.1    Biesinger, B.2    Knappe, A.3    Wittmann, S.4    Fleckenstein, B.5
  • 16
    • 1842294583 scopus 로고    scopus 로고
    • Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus saimiri
    • Fickenscher H., Bokel C., Knappe A., Biesinger B., Meinl E., Fleischer B., Fleckenstein B., Broker B.M. Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus saimiri. J. Virol. 71(3):1997;2252-2263.
    • (1997) J. Virol. , vol.71 , Issue.3 , pp. 2252-2263
    • Fickenscher, H.1    Bokel, C.2    Knappe, A.3    Biesinger, B.4    Meinl, E.5    Fleischer, B.6    Fleckenstein, B.7    Broker, B.M.8
  • 17
    • 0030816363 scopus 로고    scopus 로고
    • Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation
    • Gallego M.D., Santamaria M., Pena J., Molina I.J. Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation. Blood. 90(8):1997;3089-3097.
    • (1997) Blood , vol.90 , Issue.8 , pp. 3089-3097
    • Gallego, M.D.1    Santamaria, M.2    Pena, J.3    Molina, I.J.4
  • 18
    • 0030761720 scopus 로고    scopus 로고
    • Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus saimiri Tip
    • Guo J., Duboise M., Lee H., Li M., Choi J.K., Rosenzweig M., Jung J.U. Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus saimiri Tip. J. Virol. 71(9):1997;7092-7096.
    • (1997) J. Virol. , vol.71 , Issue.9 , pp. 7092-7096
    • Guo, J.1    Duboise, M.2    Lee, H.3    Li, M.4    Choi, J.K.5    Rosenzweig, M.6    Jung, J.U.7
  • 19
    • 0034595880 scopus 로고    scopus 로고
    • Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip
    • Hartley D.A., Cooper G.M. Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275(22):2000;16925-16932.
    • (2000) J. Biol. Chem. , vol.275 , Issue.22 , pp. 16925-16932
    • Hartley, D.A.1    Cooper, G.M.2
  • 20
    • 0033575209 scopus 로고    scopus 로고
    • Activation of the lck tyrosine-protein kinase by the binding of the Tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation
    • Hartley D.A., Hurley T.R., Hardwick J.S., Lund T.C., Medveczky P.G., Sefton B.M. Activation of the lck tyrosine-protein kinase by the binding of the Tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation. J. Biol. Chem. 274(29):1999;20056-20059.
    • (1999) J. Biol. Chem. , vol.274 , Issue.29 , pp. 20056-20059
    • Hartley, D.A.1    Hurley, T.R.2    Hardwick, J.S.3    Lund, T.C.4    Medveczky, P.G.5    Sefton, B.M.6
  • 21
    • 0034715580 scopus 로고    scopus 로고
    • Activation of the Lck tyrosine protein kinase by the herpesvirus saimiri Tip protein involves two binding interactions
    • Hartley D.A., Amdjadi K., Hurley T.R., Lund T.C., Medveczky P.G., Sefton B.M. Activation of the Lck tyrosine protein kinase by the herpesvirus saimiri Tip protein involves two binding interactions. Virology. 276(2):2000;339-348.
    • (2000) Virology , vol.276 , Issue.2 , pp. 339-348
    • Hartley, D.A.1    Amdjadi, K.2    Hurley, T.R.3    Lund, T.C.4    Medveczky, P.G.5    Sefton, B.M.6
  • 22
    • 0033544331 scopus 로고    scopus 로고
    • Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express herpesvirus saimiri proteins StpC and/or Tip
    • Henderson E.E., Tsygankov A.Y., Merlo J.J., Romano G., Guan M. Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express herpesvirus saimiri proteins StpC and/or Tip. Virology. 264(1):1999;125-133.
    • (1999) Virology , vol.264 , Issue.1 , pp. 125-133
    • Henderson, E.E.1    Tsygankov, A.Y.2    Merlo, J.J.3    Romano, G.4    Guan, M.5
  • 23
    • 0033948011 scopus 로고    scopus 로고
    • Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by herpesvirus saimiri and other viral gene products
    • Isakov N., Biesinger B. Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by herpesvirus saimiri and other viral gene products. Eur. J. Biochem. 267(12):2000;3413-3421.
    • (2000) Eur. J. Biochem. , vol.267 , Issue.12 , pp. 3413-3421
    • Isakov, N.1    Biesinger, B.2
  • 25
    • 0028788824 scopus 로고
    • Association of the viral oncoprotein STP-C488 with cellular Ras
    • Jung J.U., Desrosiers R.C. Association of the viral oncoprotein STP-C488 with cellular Ras. Mol. Cell. Biol. 15(12):1995;6506-6512.
    • (1995) Mol. Cell. Biol. , vol.15 , Issue.12 , pp. 6506-6512
    • Jung, J.U.1    Desrosiers, R.C.2
  • 28
    • 0028800298 scopus 로고
    • Downregulation of Lck-mediated signal transduction by Tip of herpesvirus saimiri
    • Jung J.U., Lang S.M., Jun T., Roberts T.M., Veillette A., Desrosiers R.C. Downregulation of Lck-mediated signal transduction by Tip of herpesvirus saimiri. J. Virol. 69(12):1995;7814-7822.
    • (1995) J. Virol. , vol.69 , Issue.12 , pp. 7814-7822
    • Jung, J.U.1    Lang, S.M.2    Jun, T.3    Roberts, T.M.4    Veillette, A.5    Desrosiers, R.C.6
  • 29
    • 0033022846 scopus 로고    scopus 로고
    • Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis
    • Jung J.U., Choi J.K., Ensser A., Biesinger B. Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis. Semin. Cancer Biol. 9(3):1999;231-239.
    • (1999) Semin. Cancer Biol. , vol.9 , Issue.3 , pp. 231-239
    • Jung, J.U.1    Choi, J.K.2    Ensser, A.3    Biesinger, B.4
  • 30
    • 0036308581 scopus 로고    scopus 로고
    • The herpesvirus saimiri Tip484 and Tip488 proteins both stimulate Lck tyrosine protein kinase activity in vivo and in vitro
    • Kjellen P., Amdjadi K., Lund T.C., Medveczky P.G., Sefton B.M. The herpesvirus saimiri Tip484 and Tip488 proteins both stimulate Lck tyrosine protein kinase activity in vivo and in vitro. Virology. 297(2):2002;281-288.
    • (2002) Virology , vol.297 , Issue.2 , pp. 281-288
    • Kjellen, P.1    Amdjadi, K.2    Lund, T.C.3    Medveczky, P.G.4    Sefton, B.M.5
  • 31
    • 0030785477 scopus 로고    scopus 로고
    • The superantigen-homologous viral immediate-early gene Ie14/Vsag in herpesvirus saimiri-transformed human T cells
    • Knappe A., Hiller C., Thurau M., Wittmann S., Hofmann H., Fleckenstein B., Fickenscher H. The superantigen-homologous viral immediate-early gene Ie14/Vsag in herpesvirus saimiri-transformed human T cells. J. Virol. 71(12):1997;9124-9133.
    • (1997) J. Virol. , vol.71 , Issue.12 , pp. 9124-9133
    • Knappe, A.1    Hiller, C.2    Thurau, M.3    Wittmann, S.4    Hofmann, H.5    Fleckenstein, B.6    Fickenscher, H.7
  • 32
    • 0032502655 scopus 로고    scopus 로고
    • Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual
    • Lacey S.F., Weinhold K.J., Chen C.H., McDanal C., Oei C., Greenberg M.L. Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual. AIDS Res. Hum. Retroviruses. 14(6):1998;521-531.
    • (1998) AIDS Res. Hum. Retroviruses , vol.14 , Issue.6 , pp. 521-531
    • Lacey, S.F.1    Weinhold, K.J.2    Chen, C.H.3    McDanal, C.4    Oei, C.5    Greenberg, M.L.6
  • 33
    • 0031465970 scopus 로고    scopus 로고
    • Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells
    • Latinis K.M., Norian L.A., Eliason S.L., Koretzky G.A. Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells. J. Biol. Chem. 272(50):1997;31427-31434.
    • (1997) J. Biol. Chem. , vol.272 , Issue.50 , pp. 31427-31434
    • Latinis, K.M.1    Norian, L.A.2    Eliason, S.L.3    Koretzky, G.A.4
  • 34
    • 0032898259 scopus 로고    scopus 로고
    • Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus saimiri STP
    • Lee H., Choi J.K., Li M., Kaye K., Kieff E., Jung J.U. Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus saimiri STP. J. Virol. 73(5):1999;3913-3919.
    • (1999) J. Virol. , vol.73 , Issue.5 , pp. 3913-3919
    • Lee, H.1    Choi, J.K.2    Li, M.3    Kaye, K.4    Kieff, E.5    Jung, J.U.6
  • 35
    • 0030025859 scopus 로고    scopus 로고
    • Regulation of Epstein-Barr virus latency by latent membrane protein 2
    • Longnecker R., Miller C.L. Regulation of Epstein-Barr virus latency by latent membrane protein 2. Trends Microbiol. 4(1):1996;38-42.
    • (1996) Trends Microbiol. , vol.4 , Issue.1 , pp. 38-42
    • Longnecker, R.1    Miller, C.L.2
  • 36
    • 0029655457 scopus 로고    scopus 로고
    • A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck
    • Lund T., Medveczky M.M., Neame P.J., Medveczky P.G. A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck. J. Virol. 70(1):1996;600-606.
    • (1996) J. Virol. , vol.70 , Issue.1 , pp. 600-606
    • Lund, T.1    Medveczky, M.M.2    Neame, P.J.3    Medveczky, P.G.4
  • 37
    • 0031060289 scopus 로고    scopus 로고
    • Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells
    • Lund T., Medveczky M., Medveczky P. Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells. J. Virol. 71(1):1997;378-382.
    • (1997) J. Virol. , vol.71 , Issue.1 , pp. 378-382
    • Lund, T.1    Medveczky, M.2    Medveczky, P.3
  • 38
    • 0030761716 scopus 로고    scopus 로고
    • Activation of STAT transcription factors by herpesvirus saimiri Tip-484 requires p56lck
    • Lund T.C., Garcia R., Medveczky M.M., Jove R., Medveczky P.G. Activation of STAT transcription factors by herpesvirus saimiri Tip-484 requires p56lck. J. Virol. 71(9):1997;6677-6682.
    • (1997) J. Virol. , vol.71 , Issue.9 , pp. 6677-6682
    • Lund, T.C.1    Garcia, R.2    Medveczky, M.M.3    Jove, R.4    Medveczky, P.G.5
  • 39
    • 0032927057 scopus 로고    scopus 로고
    • The Lck binding domain of herpesvirus saimiri Tip-484 constitutively activates Lck and STAT3 in T cells
    • Lund T.C., Prator P.C., Medveczky M.M., Medveczky P.G. The Lck binding domain of herpesvirus saimiri Tip-484 constitutively activates Lck and STAT3 in T cells. J. Virol. 73(2):1999;1689-1694.
    • (1999) J. Virol. , vol.73 , Issue.2 , pp. 1689-1694
    • Lund, T.C.1    Prator, P.C.2    Medveczky, M.M.3    Medveczky, P.G.4
  • 41
    • 0027437210 scopus 로고
    • IL-2 independent growth and cytotoxicity of herpesvirus saimiri-infected human CD8 cells and involvement of two open reading frame sequences of the virus
    • Medveczky M.M., Geck P., Sullivan J.L., Serbousek D., Djeu J.Y., Medveczky P.G. IL-2 independent growth and cytotoxicity of herpesvirus saimiri-infected human CD8 cells and involvement of two open reading frame sequences of the virus. Virology. 196(2):1993;402-412.
    • (1993) Virology , vol.196 , Issue.2 , pp. 402-412
    • Medveczky, M.M.1    Geck, P.2    Sullivan, J.L.3    Serbousek, D.4    Djeu, J.Y.5    Medveczky, P.G.6
  • 42
    • 0033977309 scopus 로고    scopus 로고
    • T cell transformation with herpesvirus saimiri: A tool for neuroimmunological research
    • Meinl E., Hohlfeld R. T cell transformation with herpesvirus saimiri: a tool for neuroimmunological research. J. Neuroimmunol. 103(1):2000;1-7.
    • (2000) J. Neuroimmunol. , vol.103 , Issue.1 , pp. 1-7
    • Meinl, E.1    Hohlfeld, R.2
  • 44
    • 0035915985 scopus 로고    scopus 로고
    • Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate NF-kappaB activity and interleukin-2 gene expression
    • Merlo J.J., Tsygankov A.Y. Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate NF-kappaB activity and interleukin-2 gene expression. Virology. 279(1):2001;325-338.
    • (2001) Virology , vol.279 , Issue.1 , pp. 325-338
    • Merlo, J.J.1    Tsygankov, A.Y.2
  • 46
    • 0026673450 scopus 로고
    • CD2-mediated autocrine growth of Herpes virus saimiri-transformed human T lymphocytes
    • Mittrucker H.W., Muller-Fleckenstein I., Fleckenstein B., Fleischer B. CD2-mediated autocrine growth of Herpes virus saimiri-transformed human T lymphocytes. J. Exp. Med. 176(3):1992;909-913.
    • (1992) J. Exp. Med. , vol.176 , Issue.3 , pp. 909-913
    • Mittrucker, H.W.1    Muller-Fleckenstein, I.2    Fleckenstein, B.3    Fleischer, B.4
  • 47
    • 0027324293 scopus 로고
    • Herpes virus saimiri-transformed human T lymphocytes: Normal functional phenotype and preserved T cell receptor signalling
    • Mittrucker H.W., Muller-Fleckenstein I., Fleckenstein B., Fleischer B. Herpes virus saimiri-transformed human T lymphocytes: normal functional phenotype and preserved T cell receptor signalling. Int. Immunol. 5(8):1993;985-990.
    • (1993) Int. Immunol. , vol.5 , Issue.8 , pp. 985-990
    • Mittrucker, H.W.1    Muller-Fleckenstein, I.2    Fleckenstein, B.3    Fleischer, B.4
  • 48
    • 0035451092 scopus 로고    scopus 로고
    • Abnormal T cell receptor signal transduction of CD4 TH cells in X-linked lymphoproliferative syndrome
    • Nakamura H., Zarycki J., Sullivan J.L., Jung J.U. Abnormal T cell receptor signal transduction of CD4 TH cells in X-linked lymphoproliferative syndrome. J. Immunol. 167(5):2001;2657-2665.
    • (2001) J. Immunol. , vol.167 , Issue.5 , pp. 2657-2665
    • Nakamura, H.1    Zarycki, J.2    Sullivan, J.L.3    Jung, J.U.4
  • 49
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L., Blomer U., Gallay P., Ory D., Mulligan R., Gage F.H., Verma I.M., Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 272(5259):1996;263-267.
    • (1996) Science , vol.272 , Issue.5259 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3    Ory, D.4    Mulligan, R.5    Gage, F.H.6    Verma, I.M.7    Trono, D.8
  • 51
    • 0036669787 scopus 로고    scopus 로고
    • Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression
    • Park J., Lee B.S., Choi J.K., Means R.E., Choe J., Jung J.U. Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression. Immunity. 17(2):2002;221-233.
    • (2002) Immunity , vol.17 , Issue.2 , pp. 221-233
    • Park, J.1    Lee, B.S.2    Choi, J.K.3    Means, R.E.4    Choe, J.5    Jung, J.U.6
  • 55
    • 0029905036 scopus 로고    scopus 로고
    • Generation of CD4+ and CD8+ T-cell clones from PBLs of HIV-1 infected subjects using herpesvirus saimiri
    • Saha K., Sova P., Chao W., Chess L., Volsky D.J. Generation of CD4+ and CD8+ T-cell clones from PBLs of HIV-1 infected subjects using herpesvirus saimiri. Nat. Med. 2(11):1996;1272-1275.
    • (1996) Nat. Med. , vol.2 , Issue.11 , pp. 1272-1275
    • Saha, K.1    Sova, P.2    Chao, W.3    Chess, L.4    Volsky, D.J.5
  • 56
    • 0030965243 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) infection of herpesvirus saimiri-immortalized human CD4-positive T lymphoblastoid cells: Evidence of enhanced HIV-1 replication and cytopathic effects caused by endogenous interferon-gamma
    • Saha K., Caruso M., Volsky D.J. Human immunodeficiency virus type 1 (HIV-1) infection of herpesvirus saimiri-immortalized human CD4-positive T lymphoblastoid cells: evidence of enhanced HIV-1 replication and cytopathic effects caused by endogenous interferon-gamma. Virology. 231(1):1997;1-9.
    • (1997) Virology , vol.231 , Issue.1 , pp. 1-9
    • Saha, K.1    Caruso, M.2    Volsky, D.J.3
  • 57
    • 0031964686 scopus 로고    scopus 로고
    • Endogenous production of beta-chemokines by CD4+, but not CD8+, T-cell clones correlates with the clinical state of human immunodeficiency virus type 1 (HIV-1)-infected individuals and may be responsible for blocking infection with non-syncytium-inducing HIV-1 in vitro
    • Saha K., Bentsman G., Chess L., Volsky D.J. Endogenous production of beta-chemokines by CD4+, but not CD8+, T-cell clones correlates with the clinical state of human immunodeficiency virus type 1 (HIV-1)-infected individuals and may be responsible for blocking infection with non-syncytium-inducing HIV-1 in vitro. J. Virol. 72(1):1998;876-881.
    • (1998) J. Virol. , vol.72 , Issue.1 , pp. 876-881
    • Saha, K.1    Bentsman, G.2    Chess, L.3    Volsky, D.J.4
  • 58
    • 0032864440 scopus 로고    scopus 로고
    • Resistance against syncytium-inducing human immunodeficiency virus type 1 (HIV-1) in selected CD4(+) T cells from an HIV-1-infected nonprogressor: Evidence of a novel pathway of resistance mediated by a soluble factor(s) that acts after virus entry
    • Saha K., Volsky D.J., Matczak E. Resistance against syncytium-inducing human immunodeficiency virus type 1 (HIV-1) in selected CD4(+) T cells from an HIV-1-infected nonprogressor: evidence of a novel pathway of resistance mediated by a soluble factor(s) that acts after virus entry. J. Virol. 73(9):1999;7891-7898.
    • (1999) J. Virol. , vol.73 , Issue.9 , pp. 7891-7898
    • Saha, K.1    Volsky, D.J.2    Matczak, E.3
  • 60
    • 0026705903 scopus 로고
    • Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
    • Straus D.B., Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 70(4):1992;585-593.
    • (1992) Cell , vol.70 , Issue.4 , pp. 585-593
    • Straus, D.B.1    Weiss, A.2
  • 62
    • 0033040004 scopus 로고    scopus 로고
    • Mechanisms of cell transformation by Herpesvirus saimiri
    • Tsygankov A.Y., Romano G. Mechanisms of cell transformation by Herpesvirus saimiri. Anticancer Res. 19(2A):1999;973-983.
    • (1999) Anticancer Res. , vol.19 , Issue.2 A , pp. 973-983
    • Tsygankov, A.Y.1    Romano, G.2
  • 63
    • 0023754126 scopus 로고
    • Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation
    • Veillette A., Horak I.D., Horak E.M., Bookman M.A., Bolen J.B. Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation. Mol. Cell. Biol. 8(10):1988;4353-4361.
    • (1988) Mol. Cell. Biol. , vol.8 , Issue.10 , pp. 4353-4361
    • Veillette, A.1    Horak, I.D.2    Horak, E.M.3    Bookman, M.A.4    Bolen, J.B.5
  • 64
    • 0031009550 scopus 로고    scopus 로고
    • Herpesvirus saimiri-immortalized human T-cells support long-term, high titred replication of human immunodeficiency virus types 1 and 2
    • Vella C., Fickenscher H., Atkins C., Penny M., Daniels R. Herpesvirus saimiri-immortalized human T-cells support long-term, high titred replication of human immunodeficiency virus types 1 and 2. J. Gen. Virol. 78(Pt 6):1997;1405-1409.
    • (1997) J. Gen. Virol. , vol.78 , Issue.PT 6 , pp. 1405-1409
    • Vella, C.1    Fickenscher, H.2    Atkins, C.3    Penny, M.4    Daniels, R.5
  • 65
    • 0032960884 scopus 로고    scopus 로고
    • Enhanced replication of M-tropic HIV-1 strains in Herpesvirus saimiri immortalised T-cells which express CCR5
    • Vella C., Zheng N.N., Vella G., Atkins C., Bristow R.G.W., Fickenscher H., Daniels R.S. Enhanced replication of M-tropic HIV-1 strains in Herpesvirus saimiri immortalised T-cells which express CCR5. J. Virol. Methods. 79(1):1999;51-63.
    • (1999) J. Virol. Methods , vol.79 , Issue.1 , pp. 51-63
    • Vella, C.1    Zheng, N.N.2    Vella, G.3    Atkins, C.4    Bristow, R.G.W.5    Fickenscher, H.6    Daniels, R.S.7
  • 66
    • 0036382756 scopus 로고    scopus 로고
    • Herpesvirus saimiri-immortalized human lymphocytes: Novel hosts for analyzing HIV type 1 in vitro neutralization
    • Vella C., Zheng N.N., Easterbrook P., Daniels R.S. Herpesvirus saimiri-immortalized human lymphocytes: novel hosts for analyzing HIV type 1 in vitro neutralization. AIDS Res. Hum. Retroviruses. 18(13):2002;933-946.
    • (2002) AIDS Res. Hum. Retroviruses , vol.18 , Issue.13 , pp. 933-946
    • Vella, C.1    Zheng, N.N.2    Easterbrook, P.3    Daniels, R.S.4
  • 67
    • 0027421614 scopus 로고
    • Phosphorylation of serine-59 of p56(lck) in activated T-cells
    • Watts J.D., Sanghera J.S., Pelech S.L., Aebersold R. Phosphorylation of serine-59 of p56(lck) in activated T-cells. J. Biol. Chem. 268(31):1993;23275- 23282.
    • (1993) J. Biol. Chem. , vol.268 , Issue.31 , pp. 23275-23282
    • Watts, J.D.1    Sanghera, J.S.2    Pelech, S.L.3    Aebersold, R.4
  • 71
    • 0036267818 scopus 로고    scopus 로고
    • Selection following isolation of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and herpesvirus saimiri-transformed T cells is comparable
    • Zheng N.N., Vella C., Easterbrook P.J., Daniels R.S. Selection following isolation of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and herpesvirus saimiri-transformed T cells is comparable. J. Gen. Virol. 83(Pt 6):2002;1343-1352.
    • (2002) J. Gen. Virol. , vol.83 , Issue.PT 6 , pp. 1343-1352
    • Zheng, N.N.1    Vella, C.2    Easterbrook, P.J.3    Daniels, R.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.