Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression

Immunity

Volumn 17, Issue 2, 2002, Pages 221-233

  Park, Junsoo ^a,b   Lee, Bok Soo ^a   Choi, Joong Kook ^a   Means, Robert E ^a   Choe, Joonho ^b   Jung, Jae U ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; ISOPROTEIN; PROTEIN KINASE LCK; PROTEIN P80; PROTEIN TIP; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; ENDOSOME; HERPES VIRUS; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION;

EID: 0036669787     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00368-0     Document Type: Article

References (31)

1. al-Ramadi B.K., Nakamura T., Leitenberg D., Bothwell A.L. Deficient expression of p56(lck) in Th2 cells leads to partial TCR signaling and a dysregulation in lymphokine mRNA levels. J. Immunol. 157:1996;4751-4761.
2. Andre P., Boretto J., Hueber A.O., Regnier-Vigouroux A., Gorvel J.P., Ferrier P., Chavrier P. A dominant-negative mutant of the Rab5 GTPase enhances T cell signaling by interfering with TCR down-modulation in transgenic mice. J. Immunol. 159:1997;5253-5263.
3. Biesinger B., Muller-Fleckenstein I., Simmer B., Lang G., Wittmann S., Platzer E., Desrosiers R.C., Fleckenstein B. Stable growth transformation of human T lymphocytes by herpesvirus saimiri. Proc. Natl. Acad. Sci. USA. 89:1992;3116-3119.
4. Biesinger B., Tsygankov A.Y., Fickenscher H., Emmrich F., Fleckenstein B., Bolen J.B., Broker B.M. The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J. Biol. Chem. 270:1995;4729-4734.
5. Bucci C., Parton R.G., Mather I.H., Stunnenberg H., Simons K., Hoflack B., Zerial M. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell. 70:1992;715-728.
6. Burkhardt A.L., Bolen J.B., Kieff E., Longnecker R. An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases. J. Virol. 66:1992;5161-5167.
7. Callan M.F., McMichael A.J. T cell receptor usage in infectious disease. Springer Semin. Immunopathol. 21:1999;37-54.
8. Cenciarelli C., Wilhelm K.G. Jr., Guo A., Weissman A.M. T cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activation. J. Biol. Chem. 271:1996;8709-8713.
9. D'Oro U., Vacchio M.S., Weissman A.M., Ashwell J.D. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity. 7:1997;619-628.
10. Desrosiers R.C., Bakker A., Kamine J., Falk L.A., Hunt R.D., King N.W. A region of the Herpesvirus saimiri genome required for oncogenicity. Science. 228:1985;184-187.
11. Duboise S.M., Guo J., Czajak S., Desrosiers R.C., Jung J.U. STP and Tip are essential for herpesvirus saimiri oncogenicity. J. Virol. 72:1998;1308-1313.
12. Fruehling S., Longnecker R. The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction. Virology. 235:1997;241-251.
13. Guo J., Duboise M., Lee H., Li M., Choi J.K., Rosenzweig M., Jung J.U. Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus Saimiri tip. J. Virol. 71:1997;7092-7096.
14. Ikeda M., Ikeda A., Longan L.C., Longnecker R. The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases. Virology. 268:2000;178-191.
15. Ikeda M., Ikeda A., Longnecker R. PY motifs of Epstein-Barr virus LMP2A regulate protein stability and phosphorylation of LMP2A-associated proteins. J. Virol. 75:2001;5711-5718.
16. Isakov N., Biesinger B. Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products. Eur. J. Biochem. 267:2000;3413-3421.
17. Jung J.U., Lang S.M., Friedrich U., Jun T., Roberts T.M., Desrosiers R.C., Biesinger B. Identification of Lck-binding elements in tip of herpesvirus saimiri. J. Biol. Chem. 270:1995;20660-20667. a.
18. Jung J.U., Lang S.M., Jun T., Roberts T.M., Veillette A., Desrosiers R.C. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. J. Virol. 69:1995;7814-7822. b.
19. Jung J.U., Choi J.K., Ensser A., Biesinger B. Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis. Semin. Cancer Biol. 9:1999;231-239.
20. Mittrucker H.W., Muller-Fleckenstein I., Fleckenstein B., Fleischer B. CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes. J. Exp. Med. 176:1992;909-913.
21. Molina T.J., Kishihara K., Siderovski D.P., van Ewijk W., Narendran A., Timms E., Wakeham A., Paige C.J., Hartmann K.U., Veilette A.et al. Profound block in thymocyte development in mice lacking p65ick. Nature. 357:1992;161-164.
22. Neer E.J., Schmidt C.J., Nambudripad R., Smith T.F. The ancient regulatory-protein family of WD-repeat proteins. Nature. 371:1994;297-300.
23. Stenmark H., Parton R.G., Steele-Mortimer O., Lutcke A., Gruenberg J., Zerial M. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J. 13:1994;1287-1296.
24. Straus D.B., Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 70:1992;585-593.
25. ter Haar E., Musacchio A., Harrison S.C., Kirchhausen T. Atomic structure of clathrin. a β propeller terminal domain joins an α zigzag linker Cell. 95:1998;563-573.
26. Veillette A., Bookman M.A., Horak E.M., Bolen J.B. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell. 55:1988;301-308.
27. Wall M.A., Coleman D.E., Lee E., Iniguez-Lluhi J.A., Posner B.A., Gilman A.G., Sprang S.R. The structure of the G protein heterotrimer Giα1β1γ2. Cell. 83:1995;1047-1058.
28. Weil R., Veillette A. Signal transduction by the lymphocyte-specific tyrosine protein kinase p56lck. Curr. Top. Microbiol. Immunol. 205:1996;63-87.
29. Weil R., Levraud J.P., Dodon M.D., Bessia C., Hazan U., Kourilsky P., Israel A. Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines. J. Virol. 73:1999;3709-3717.
30. Weiss A. T Lymphocyte activation. Paul W.E. Fundamental Immunology. 3rd Edition:1993;Raven Press, New York.
31. Winberg G., Matskova L., Chen F., Plant P., Rotin D., Gish G., Ingham R., Ernberg I., Pawson T. Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol. Cell. Biol. 20:2000;8526-8535.