The herpesvirus saimiri Tip484 and Tip488 proteins both stimulate Lck tyrosine protein kinase activity in vivo and in vitro

Virology

Volumn 297, Issue 2, 2002, Pages 281-288

  Kjellen, Peter ^a,b   Amdjadi, Kambiz ^a   Lund, Troy C ^b   Medveczky, Peter G ^b   Sefton, Bartholomew M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Herpesvirus; HVS; Kinase; Lck; NF AT; Saimiri; STAT; Tip; Tyrosine

Indexed keywords

ISOPROTEIN; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; TRANSCRIPTION FACTOR NFAT; TYROSINE KINASE INTERACTING PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HERPES VIRUS INFECTION; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; VIRUS STRAIN;

HERPESVIRIDAE; PRIMATES; SAIMIRI; SAIMIRIINE HERPESVIRUS 2; SUBGROUP C;

EID: 0036308581     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1419     Document Type: Article

References (39)

1. Stable growth transformation of human T lymphocytes by herpesvirus saimiri
2. The divergence between two oncogenic herpesvirus saimiri strains in a genomic region related to the transforming phenotype
3. The product of the herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells
4. Precursors of T cell growth factor producing cells in the thymus: Ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5
5. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk
6. A region of the herpesvirus saimiri genome required for oncogenicity
7. STP and Tip are essential for herpesvirus saimiri oncogenicity
8. Herpesvirus saimiri
9. Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri
10. Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus Saimiri tip
11. Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394
12. Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions
13. Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein tip
14. Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation
15. Analysis of the activity and phosphorylation of the lck protein in lymphoid cells
16. Coordinate change in phenotype in a mouse cell line selected for CD8 expression
17. Identification and characterization of the herpesvirus saimiri oncoprotein STP-C488
18. Identification of Lck-binding elements in tip of herpesvirus saimiri
19. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri
20. Identification of transforming genes of subgroup A and C strains of herpesvirus saimiri
21. Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine
22. A dominant-negative transgene defines a role for p56lck in thymopoiesis
23. Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells
24. A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck
25. Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck
26. Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells
27. IL-2 independent growth and cytotoxicity of herpesvirus saimiri-infected human CD8 cells and involvement of two open reading frame sequences of the virus
28. Classification of herpesvirus saimiri into three groups based on extreme variation in a DNA region required for oncogenicity
29. Acute lymphocytic leukemia in owl monkeys inoculated with herpesvirus saimiri
30. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
31. Profound block in thymocyte development in mice lacking p56lck
32. Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation
33. Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex
34. The lck tyrosine protein kinase
35. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
36. Herpesvirus saimiri Tip gene causes T-cell lymphomas in transgenic mice
37. Selective activation of T cell kinase p56lck by herpesvirus saimiri protein tip
38. Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia
39. Three-dimensional structure of the tyrosine kinase c-Src