Functional phenotype of transformed human αβ and γδ T cells determined by different subgroup C strains of herpesvirus saimiri

Journal of Virology

Volumn 71, Issue 3, 1997, Pages 2252-2263

  Fickenscher, Helmut ^a,c   Bökel, Christian ^a,d   Knappe, Andrea ^a   Biesinger, Brigitte ^a   Meinl, Edgar ^a   Fleischer, Bernhard ^b   Fleckenstein, Bernhard ^a   Bröker, Barbara M ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^d MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

ARTICLE; CELL IMMORTALIZATION; GENE EXPRESSION; GENETIC TRANSFORMATION; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; PERSISTENT VIRUS INFECTION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 1842294583     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.3.2252-2263.1997     Document Type: Article

References (68)

1. Albrecht, J., J. Nicholas, D. Biller, K. Cameron, B. Biesinger, C. Newman, S. Wittmann, M. Craxton, H. Coleman, B. Fleckenstein, and R. Honess. 1992. Primary structure of the herpesvirus saimiri genome. J. Virol. 66:5047-5058.
2. Ausubel, F., R. Brent, R. E. Kingston, D. D. Moore, J. Seidman, J. A. Smith, and K. Struhl (ed.). 1995. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
3. + cytotoxic T lymphocytes. J. Virol. 67:6317-6321.
4. Biesinger, B., I. Müller-Fleckenstein, B. Simmer, G. Lang, S. Wittmann, E. Platzer, R. Desrosiers, and B. Fleckenstein. 1992. Stable growth transformation of human T-lymphocytes by herpesvirus saimiri. Proc. Natl. Acad. Sci. USA 89:3116-3119.
5. Biesinger, B., J. Trimble, R. Desrosiers, and B. Fleckenstein. 1990. The divergence between two oncogenic herpesvirus saimiri strains in a genomic region related to the transforming phenotype. Virology 176:505-514.
6. Biesinger, B., A. Tsygankov, H. Fickenscher, F. Emmrich, B. Fleckenstein, J. Bolen, and B. Bröker. 1995. The product of the herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J. Biol. Chem. 270:4729-4734.
7. Bolen, J., R. Rowley, C. Spana, and A. Tsygankov. 1992. The SRC family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 6:3403-3409.
8. Bröker, B., A. Tsygankov, I. Müller-Fleckenstein, A. Guse, N. Chitaev, B. Biesinger, B. Fleckenstein, and F. Emmrich. 1993. Immortalization of human T cell clones by herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4 and IL-2 receptors. J. Immunol. 51:1184-1192.
9. Chien, Y., R. Jores, and M. Crowley. 1996. Recognition by γ/δ T cells. Annu. Rev. Immunol. 14:511-532.
10. Chomarat, P., J. Kjeldsen-Kragh, A. Quayle, J. Natvig, and P. Miossec. 1994. Different cytokine production profiles of γδ T cell clones: relation to inflammatory arthritis. Eur. J. Immunol. 24:2087-2091.
11. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
12. Christmas, S., and A. Meager. 1990. Production of interferon-γ and tumour necrosis factor-α by human T-cell clones expressing different forms of the γδ receptor. Immunology 71:486-492.
13. Daniel, M., D. Silva, and N. Ma. 1976. Establishment of owl monkey kidney 210 cell line for virological studies. In Vitro 12:290.
14. Danielian, S., R. Fagard, A. Alcover, O. Acuto, and S. Fischer. 1991. The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2 Eur. J. Immunol. 21:1967-1970.
15. De Carli, M., S. Berthold, H. Fickenscher, I. Müller-Fleckenstein, M. D'Elios, Q. Gao, R. Biagiotti, M. Giudizi, J. Kalden, B. Fleckenstein, S. Romagnani, and G. Del Prete. 1993. Immortalization with herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones. J. Immunol. 151:5022-5030.
16. Del Prete, G., M. De Carli, M. D'Elios, I. Müller-Fleckenstein, H. Fickenscher, B. Fleckenstein, F. Almerigogna, and S. Romagnani. 1994. Polyclonal B cell activation induced by herpesvirus saimiri-transformed human CD4+ T cell clones: role for membrane TNF-α/TNF-α receptors and CD2/CD58 interactions. J. Immunol. 152:4872-4879.
17. Desrosiers, R., and L. Falk. 1982. Herpesvirus saimiri strain variability. J. Virol. 43:352-356.
18. Desrosiers, R., A. Bakker, J. Kamine, L. Falk, R. Hunt, and N. King. 1985. A region of the herpesvirus saimiri genome required for oncogenicity. Science 228:184-187.
19. Desrosiers, R., R. Burghoff, A. Bakker, and J. Kamine. 1984. Construction of replication-competent herpesvirus saimiri deletion mutants. J. Virol. 49:343-348.
20. Desrosiers, R., D. Silva, L. Waldron, and N. Letvin. 1986. Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization. J. Virol. 57:701-705.
21. Feinberg, A., and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13.
22. Fickenscher, H., and B. Fleckenstein. 1994. Generation of human T-cell lines using lymphotropic herpesviruses. Methods Mol. Genet. 4:345-362.
23. Fickenscher, H., B. Biesinger, A. Knappe, S. Wittmann, and B. Fleckenstein. 1996. Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes in growth-transformed human T lymphocytes. J. Virol. 70:6012-6019.
24. Fickenscher, H., E. Meinl, A. Knappe, S. Wittmann, and B. Fleckenstein. 1996. TCR expression of herpesvirus saimiri immortalized human T cells. Immunologist 4:41-43.
25. Fleckenstein, B., and R. Desrosiers. 1982. Herpesvirus saimiri and herpesvirus ateles, p. 253-331. In B. Roizman (ed.), The herpesviruses, vol. 1. Plenum Press, New York, N.Y.
26. Fleischer, B. 1987. A novel pathway of human T lymphocyte activation via a 103 kd T cell activation antigen. J. Immunol. 138:1346.
27. Gardella, T., P. Medveczky, T. Sairenji, and C. Mulder. 1984. Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis. J. Virol. 50:248-254.
28. Geck, P., S. Whitaker, M. Medveczky, and P. Medveczky. 1990. Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri. J. Virol. 64: 3509-3515.
29. Geck, P., S. Whitaker, M. Medveczky, and P. Medveczky. 1991. Erratum. Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri. J. Virol. 65:7084.
30. Haas, W., P. Pereira, and S. Tonegawa. 1993. Gamma/delta cells. Annu. Rev. Immunol. 11:637-685.
31. Jung, J., and R. Desrosiers. 1991. Identification and characterization of the herpesvirus saimiri oncoprotein STP-C488. J. Virol. 65:6953-6960.
32. Jung, J., and R. Desrosiers. 1992. Herpesvirus saimiri oncogene STP-C488 encodes a phosphoprotein. J. Virol. 66:1777-1780.
33. Jung, J., and R. Desrosiers. 1994. Distinct functional domains of STP-C488 of herpesvirus saimiri. Virology 204:751-758.
34. Jung, J., and R. Desrosiers. 1995. Association of the viral oncoprotein Stp-C488 with cellular ras. Mol. Cell. Biol. 15:6508-6512.
35. Jung, J., S. Lang, U. Friedrich, T. Jun, T. Roberts, R. Desrosiers, and B. Biesinger. 1995. Identification of Lck-binding elements in Tip of herpesvirus saimiri. J. Biol. Chem. 270:20660-20667.
36. Jung, J., S. Lang, T. Jun, T. Roberts, A. Veillette, and R. Desrosiers. 1995. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. J. Virol. 69:7814-7822.
37. Jung, J., J. Trimble, N. King, B. Biesinger, B. Fleckenstein, and R. Desrosiers. 1991. Identification of transforming genes of subgroup A and C strains of herpesvirus saimiri. Proc. Natl. Acad. Sci. USA 88:7051-7055.
38. Klein, G., T. Lindahl, M. Jondal, W. Leibold, J. Menezes, K. Nilsson, and C. Sundström. 1974. Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas. Proc. Natl. Acad. Sci. USA 71:3283-3286.
39. Klein, J., H. Fickenscher, J. Holliday, B. Biesinger, and B. Fleckenstein. 1996. Herpesvirus saimiri immortalized γδ T cell line activated by IL-12. J. Immunol. 156:2754-2760.
40. Koomey, J., C. Mulder, R. Burghoff, B. Fleckenstein, and R. Desrosiers. 1984. Deletion of DNA sequences in a nononcogenic variant of herpesvirus saimiri. J. Virol. 50:662-665.
41. Kung, S., and P. Medveczky. 1996. Identification of a herpesvirus saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells. J. Virol. 70:1738-1744.
42. Li, Z., S. Mahajan, M. Prendergast, J. Fargnoli, X. Zhu, S. Klages, D. Adam, G. Schieven, J. Blake, J. Bolen, and A. Burkhardt. 1992. Cross-linking of surface immunoglobulin activates src-related tyrosine kinases in WEHI 231 cells. Biochem. Biophys. Res. Commun. 187:1536-1544.
43. Lund, T., M. Medveczky, P. Neame, and P. Medveczky. 1996. A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck. J. Virol. 70:600-606.
44. lck is endocytosed in Jurkat cells stimulated via CD2. J. Immunol. 148:3879-3884.
45. Marth, J., D. Lewis, C. Wilson, M. Gearn, E. Krebs, and R. Perlmutter. 1987. Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J. 6:2727-2734.
46. Medveczky, M., P. Geck, J. Sullivan, D. Serbousek, J. Djeu, and P. Medveczky. 1993. IL-2 independent growth and cytotoxicity of herpesvirus saimiri infected human CD8 cells and involvement of two open reading frame sequences of the virus. Virology 196:402-412.
47. Medveczky, M., P. Geck, R. Vassallo, and P. Medveczky. 1993. Expression of the collagen-like putative oncoprotein of herpesvirus saimiri in transformed T cells. Virus Genes 7:349-365.
48. Medveczky, M., E. Szomolanyi, R. Hesselton, D. DeGrand, P. Geck, and P. Medveczky. 1989. Herpesvirus saimiri strains from three DNA subgroups have different oncogenic potentials in New Zealand White rabbits. J. Virol. 63:3601-3611.
49. Medveczky, P., E. Szomolanyi, R. Desrosiers, and C. Mulder. 1984. Classification of herpesvirus saimiri into three groups based on extreme variation in a DNA region required for oncogenicity. J. Virol. 52:938-944.
50. Meinl, E., R. Hohlfeld, H. Wekerle, and B. Fleckenstein. 1995. Immortalization of human T cells by herpesvirus saimiri. Immunol. Today 16:55-58.
51. Meuer S., R. Hussey, M. Fabbi, D. Fox, O. Acuto, K. Fitzgerald, J. Hodgdon, J. Protentis, S. Schlossman, and E. Reinherz. 1984. An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell 35:897-906.
52. Mittrücker, H., I. Müller-Fleckenstein, B. Fleckenstein, and B. Fleischer. 1992. CD2-mediated mutual stimulation of herpesvirus saimiri-transformed human T lymphocytes. J. Exp. Med. 176:909-913.
53. Morita C., E. Beckman, J. Bukowski, Y. Tanaka, H. Band, B. Bloom, D. Golan, and M. Brenner. 1995. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 3:495-507.
54. Morita, C., C. Parker, M. Brenner, and H. Band. 1994. TCR usage and functional capabilities of human γδ T cells at birth. J. Immunol. 153:3979-3988.
55. Morita, C., S. Verma, P. Aparicio, C. Martinez, H. Spits, and M. Brenner. 1991. Functionally distinct subsets of human γδ T cells. Eur. J. Immunol. 21:2999-3007.
56. Murphy, C., C. Kretschmer, B. Biesinger, J. Beckers, J. Jung, R. Desrosiers, H. Müller-Hermelink, B. Fleckenstein, and U. Rüther. 1994. Epithelial tumors induced by a herpesvirus oncogene in transgenic mice. Oncogene 9: 221-226.
57. Murthy, S., J. Trimble, and R. Desrosiers. 1989. Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation. J. Virol. 63:3307-3314.
58. Rudd, C., O. Janssen, Y. Chai, A. da Silva, M. Raab, and K. Prasad. 1994. Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases. Immunol. Today 15:225-234.
59. Salmeron, A., F. Sanchez-Madrid, M. Ursa, M. Fresno, and B. Alarcon. 1991. A conformational epitope expressed upon association of CD3-epsilon with either CD3-delta or CD3-gamma is the main target for recognition by anti-CD3 monoclonal antibodies. J. Immunol. 147:3047-3052.
60. Schirm, S., I. Müller, R. Desrosiers, and B. Fleckenstein. 1984. Herpesvirus saimiri DNA in a lymphoid cell line established by in vitro transformation. J. Virol. 49:938-946.
61. Schneider, U., H. Schwenk, and G. Bornkamm. 1977. Characterization of EBV-genome negative 'null' and T cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma. Int. J. Cancer 19:621-626.
62. Szomolanyi, E., P. Medveczky, and C. Mulder. 1987. In vitro immortalization of marmoset cells with three subgroups of herpesvirus saimiri. J. Virol. 61:3485-3490.
63. Tanaka, Y., C. Morita, Y. Tanaka, E. Nieves, M. Brenner, and B. Bloom. 1995. Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature 375:155-158.
64. lck) during T-cell activation. Mol. Cell. Biol. 8:4353-4361.
65. Weber, F., E. Meinl, K. Drexler, A. Czlonkowska, S. Huber, H. Fickenscher, I. Müller-Fleckenstein, B. Fleckenstein, H. Wekerle, and R. Hohlfeld. 1993. Herpesvirus saimiri-transformed human T cell lines expressing functional receptor for myelin basic protein. Proc. Natl. Acad. Sci. USA 90:11049-11054.
66. Wiese, N., A. Tsygankov, U. Klauenberg, J. Bolen, B. Fleischer, and B. Bröker. 1996. Selective activation of T cell kinase p56lck by herpesvirus saimiri protein Tip. J. Biol. Chem. 271:847-852.
67. Yamanashi, Y., S. Mori, M. Yoshida, T. Kishimoto, K. Inoue, T. Yamamoto, and K. Toyoshima. 1989. Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc. Natl. Acad. Sci. USA 86:6538-6542.
68. Yasukawa, M., Y. Inoue, N. Kimura, and S. Fujita. 1995. Immortalization of human T cells expressing T-cell receptor γδ by herpesvirus saimiri. J. Virol. 69:8114-8117.