Generation of an immortalized human CD4+ T cell clone inhibiting tumor growth in mice

Biochemical and Biophysical Research Communications

Volumn 283, Issue 4, 2001, Pages 738-742

  Pecher, Gabriele ^a,b   Harnack, Ulf ^a,b   Günther, Matthias ^b   Hummel, Michael ^c   Fichtner, Iduna ^b   Schenk, Jörg A ^b,d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF POTSDAM   (Germany)

Author keywords

CD4+ T cell clone; Herpesvirus saimiri; Immortalization; Mucin (MUC1); T cell receptor

Indexed keywords

CD4 ANTIGEN; MUCIN; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CELL CLONE; CELL IMMORTALIZATION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; GROWTH INHIBITION; HERPES VIRUS; HUMAN; HUMAN CELL; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR IMMUNOLOGY;

EID: 0034810140     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4846     Document Type: Article

References (23)

1. Immunotherapy of cancer by peptide-based vaccines for the induction of tumor-specific T cell immunity
2. Human tumor antigens: Implications for cancer vaccine development
3. Generation of specific anti-melanoma reactivity by stimulation of human tumor-infiltrating lymphocytes with MAGE-1 synthetic peptide
4. Clinical observations on adoptive immunotherapy with vaccine-primed T-lymphocytes secondarily sensitized to tumor in vitro
5. Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides
6. In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen
7. Functional alterations of herpes simplex virus-specific CD4+ multifunctional T cell clones following infection with human T lymphotropic virus type I
8. Human T cell leukemia-lymphoma virus type I infection of a CD4+ proliferative-cytotoxic T cell clone progresses in at least two distinct phases based on changes in function and phenotype of the infected cells
9. W. Expression of mucin (MUC-1) from a mini-Epstein-Barr virus in immortalized B-cells to generate tumor antigen specific cytotoxic T cells
10. MUC-1 epithelial tumor mucin-based immunity and cancer vaccines
11. Immortalization of human T cells by Herpesvirus saimiri
12. Stable growth transformation of human T lymphocytes by Herpesvirus saimiri
13. Growth transformation of antigen-specific T cell lines from rhesus monkeys by Herpesvirus saimiri
14. Transformation of human T-cell clones by Herpesvirus saimiri: Intact antigen recognition by autonomously growing myelin basic protein-specific T cells
15. Herpesvirus saimiri-transformed macaque T cells are tolerated and do not cause lymphoma after autologous reinfusion
16. Proliferating dendritic cell progenitors in human blood
17. Clonal T-cell receptor y-chain gene rearrangement by PCR-based genescan analysis in advanced cutaneous T-cell lymphoma: A critical evaluation
18. High detection rate of T-cell receptor beta chain rearrangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing
19. Phenotypic and functional consequences of Herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes
20. Immortalization with Herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones
21. CD4+ lymphocytes provide MUC1-specific tumor immunity in vivo that is undetectable in vitro and is absent in MUC1 transgenic mice
22. CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma
23. Cytokine dependence of human to mouse graft-versus-host disease