The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection

Journal of NeuroVirology

Volumn 10, Issue 1, 2004, Pages 64-70

  Henderson, Gail ^a   Perng, Guey Chuen ^b   Nesburn, Anthony B ^b   Wechsler, Steven L ^b   Jones, Clinton ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Bovine herpesvirus 1 (BHV 1) latency related (LR) gene; Caspase cleavage

Indexed keywords

CASPASE 3; CASPASE 9;

APOPTOSIS; CATTLE DISEASE; DELETION MUTANT; ENZYME INHIBITION; GENE INSERTION; GENE LOCUS; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; HERPES VIRUS INFECTION; NONHUMAN; PATHOGENESIS; PLASMID; PRIORITY JOURNAL; REVIEW; VIRUS LATENCY; VIRUS REACTIVATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 9; CASPASES; CATTLE; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 1, BOVINE; NEURONS; RNA PRECURSORS; TRANSFECTION; VIRAL PROTEINS; VIRUS LATENCY;

BOVINAE; BOVINE HERPESVIRUS 1; HERPESVIRIDAE; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 1542315429     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280490261716     Document Type: Review

References (53)

1. Ahmed M, Lock M, Miller CG, Fraser NW (2002). Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo. J Virol 76: 717-729.
2. Blaho JA, Aubert M (2001). Modulation of apoptosis during herpes simplex virus infection in human cells. Microbes Infec 3: 1-8.
3. Chenet-Monte C, Mohammad F, Celluzzi CM, Schaffer PA, Farber FE (1986). Herpes simplex virus gene products involved in the induction of chromosomal aberrations. Virus Res 6: 245-260.
4. Ciacci-Zanella J, Stone M, Henderson G, Jones C (1999). The latency-related gene of bovine herpesvirus 1 inhibits programmed cell death. J Virol 73: 9734-9740.
5. Cowan CM, Thai J, Krajewski S, Reed JC, Nicholson DW, Kaufmann SH, Roskams AJ (2001). Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons. J Neurosci 21: 7099-7109.
6. Devireddy L (1999). Analysis of transcription and latency of alpha herpesviruses: identification of a neuronal-specific latency-related transcript that promotes latency and a cellular transcription factor that stimulates immediate early transcription. In: Department of Veterinary and Biomedical Sciences Communications. Lincoln, NE: University of Nebraska-Lincoln Press, pp. 309.
7. Devireddy LR, Jones C (1998). Alternative splicing of the latency-related transcript of bovine herpesvirus 1 yields RNAs containing unique open reading frames. J Virol 72: 7294-7301.
8. Galvan V, Roizman B (1998). Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell- type-dependent manner. Proc Natl Acad Sci U S A 95: 3931-3936.
9. Hagglund R, Munger J, Poon AP, Roizman B (2002). U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner. J Virol 76: 743-754.
10. Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM, Mak TW (1998). Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352.
11. Hampar B, Ellison SA (1961). Chromosomal aberrations induced by an animal virus. Nature 192: 145-147.
12. Heilbronn R, zur Hausen H (1989). A subset of herpes simplex virus replication genes induces DNA amplification within the host cell genome. J Virol 63: 3683-3692.
13. Henderson G, Peng W, Jin L, Perng G-C, Nesburn AB, Wechsler SL, Jones C (2002). Regulation of caspase 8-and caspase 9-induced apoptosis by the herpes simplex virus latency-associated transcript. J Neuro Virol 8: 103-111.
14. Hossain A, Schang LM, Jones C (1995). Identification of gene products encoded by the latency-related gene of bovine herpesvirus 1. J Virol 69: 5345-5352.
15. Inman M, Lovato L, Doster A, Jones C (2001a). A mutation in the latency-related gene of bovine herpesvirus 1 leads to impaired ocular shedding in acutely infected calves. J Virol 75: 8507-8515.
16. Inman M, Lovato L, Doster A, Jones C (2002). A mutation in the latency related gene of bovine herpesvirus 1 interferes with the latency-reactivation cycle of latency in calves. J Virol 76: 6771-6779.
17. Inman M, Perng GC, Henderson G, Ghiasi H, Nesburn AB, Wechsler SL, Jones C (2001b). Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture. J Virol 75: 3636-3646.
18. Jiang Y, Hossain A, Winkler MT, Holt T, Doster A, Jones C (1998). A protein encoded by the latency-related gene of bovine herpesvirus 1 is expressed in trigeminal ganglionic neurons of latently infected cattle and interacts with cyclin-dependent kinase 2 during productive infection. J Virol 72: 8133-8142.
19. Jin L, Peng W, Perng G-C, Nesburn AB, Jones C, Wechsler SL (2003). Identification of herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype. J Virol 77: 6556-6561.
20. Jones C (1998). Alphaherpesvirus latency: its role in disease and survival of the virus in nature. Adv Virus Res 51: 81-133.
21. Keane RW, Kraydieh S, Lotocki G, Bethea JR, Krajewski S, Reed JC, Dietrich WD (2001). Apoptotic and antiapoptotic mechanisms following spinal cord injury. J Neuropathol Exp Neurol 60: 422-429.
22. Kermer P, Ankerhold R, Klocker N, Krajewski S, Reed JC, Bahr M (2000). Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo. Brain Res Mol Brain Res 85: 144-150.
23. Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC (1999). Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A 96: 5752-5757.
24. Kruegger A, Baumann S, Krammer PH, Kirchhoff S (2001). FLICE-Inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol 21: 8247-8254.
25. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA (1998). Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337.
26. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997). Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
27. Liu X, Kim CN, Yang J, Jemmerson R, Wang X (1996). Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157.
28. Mador N, Goldenberg D, Cohen O, Panet A, Steiner I (1998). Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line. J Virol 72: 5067-5075.
29. Maggioncalda J, Mehta A, Su YH, Fraser NW, Block TM (1996). Correlation between herpes simplex virus type 1 rate of reactivation from latent infection and the number of infected neurons in trigeminal ganglia. Virology 225: 72-81.
30. Nicholson DW, Thornberry NA (1997). Caspases: killer proteases. Trends Biochem Sci 22: 299-306.
31. Olmsted JB, Carlson K, Klebe R, Ruddle F, Rosenbaum J (1970). Isolation of microtubule protein from cultured mouse neuroblastoma cells. Proc Natl Acad Sci U S A 65: 129-136.
32. Perng GC, Dunkel EC, Geary PA, Slanina SM, Ghiasi H, Kaiwar R, Nesburn AB, Wechsler SL (1994). The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J Virol 68: 8045-8055.
33. Perng GC, Ghiasi H, Slanina SM, Nesburn AB, Wechsler SL (1996). The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript. J Virol 70: 976-984.
34. Perng G-C, Jones C, Ciacci-Zanella J, Stone M, Henderson G, Yukht A, Slanina SM, Hoffman FM, Ghiasi H, Nesburn AB, Wechsler S (2000). Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript (LAT). Science 287: 1500-1503.
35. Perng G-C, Maguen B, Jin L, Mott KR, Osorio N, Slanina SM, Yukht A, Ghiasi H, Nesburn AB, Inman M, Henderson G, Jones C, Wechsler SL (2002). A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol 76: 1224-1235.
36. Perng GC, Slanina SM, Yukht A, Ghiasi H, Nesburn AB, Wechsler SL (2000). The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits. J Virol 74: 1885-1891.
37. Pilon L, Langelier Y, Royal A (1986). Herpes simplex virus type 2 mutagenesis: characterization of mutants induced at the hprt locus of nonpermissive XC cells. Mol Cell Biol 6: 2977-2983.
38. Rigamonti D, Sipione S, Goffredo D, Zuccato C, Fossale E, Cattaneo E (2001). Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing. J Biol Chem 276: 14545-14548.
39. Rock DL, Beam SL, Mayfield JE (1987). Mapping bovine herpesvirus type 1 latency-related RNA in trigeminal ganglia of latently infected rabbits. J Virol 61: 3827-3831.
40. Rock DL, Nesburn AB, Ghiasi H, Ong J, Lewis TL, Lokensgard JR, Wechsler SL (1987). Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. J Virol 61: 3820-3826.
41. Sawtell NM (1997). Comprehensive quantification of herpes simplex virus latency at the single-cell level. J Virol 71: 5423-5431.
42. Sawtell NM, Thompson RL (1992). Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. J Virol 66: 2157-2169.
43. Schang LM, Hossain A, Jones C (1996). The latency-related gene of bovine herpesvirus 1 encodes a product which inhibits cell cycle progression. J Virol 70: 3807-3814.
44. Schlehofer JR, Hausen JZ (1982). Induction of mutations within the host cell genome by partially inactivated herpes simplex virus type 1. Virology 122: 471-475.
45. Schmitz I, Kirchhoff S, Krammer PH (2000). Regulation of death receptor-mediated apoptosis pathways. Int J Biochem Cell Biol 32: 1123-1136.
46. Soengas MS, Alarcon RM, Yoshida H, Giaccia AJ, Hakem R, Mak TW, Lowe SW (1999). Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284: 156-159.
47. Thompson RL, Sawtell NM (2001). Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival. J Virol 75: 6660-6675.
48. Thompson RL, Sawtell NM (1997). The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. J Virol 71: 5432-5440.
49. Thornberry NA, Rosen A, Nicholson DW (1997). Control of apoptosis by proteases. Adv Pharmacol 41: 155-177.
50. Wang X (2001). The expanding role of mitochondria in apoptosis. Genes Dev 15: 2922-2933.
51. White E (1996). Life, death, and the pursuit of apoptosis. Genes Dev 10: 1-15.
52. Wolf BB, Green DR (1999). Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem 274: 20049-20052.
53. Zou H, Li Y, Liu X, Wang X (1999). An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274: 11549-11556.